Instructor

Prof. Bikramjit Basu

Teaching Assistant
No teaching assistant for this course Email: Not applicable

Department: BioSystems Science and Engineering

Semester: August - December, 2017

Course timing: Tue, Thurs, 5:00 PM - 6:00 PM

Course venue: MRC Classroom

Announcements

No announcements

Brief description of the course

Background, defining key elements of biomaterials science, interdisciplinary nature of biomaterials science, defining biocompatibility and related concepts, implication of biomaterials science in human healthcare, relevance of biomaterials science to biomedical device development., Biophysical processes involved in cell-material interaction (protein adsorption isotherm), cell adhesion and morphological changes on biomaterials surfaces; Cell signalling mechanism: soluble signals, classification of signalling mechanism, quantitative aspects of cell signalling, intracellular signalling mechanism, intracellular signalling proteins; Eukaryotic cell fate processes: cell differentiation, cell migration, cell division, cell death; Qualitative and quantitative assessment of cell morphological changes: some fundamentals related to microscopic analysis, fluorescence microscopy; Host response: consequences of the host response to biomaterials (foreign body response); Probing cell response, in vitro: cytotoxicity assays, flow cytometry, differentiation assays for oestrogenic markers, cell culture laboratory-testing, safety and ethical issues (good laboratory practice, cell culture maintenance), ethical considerations (stem cell research – ethical considerations, ethical concerns of tissue-engineered constructs); Bacterial growth and Biofilm formation: generic description of bacterial cell structure, classification of bacteria, bacteria-material interaction, bacteria growth, biofilm formation, experimental assessment of antibacterial properties, in vitro, experimental assessment to characterize biofilm, bacterial culture protocol; Probing tissue response, in vivo: tissue compatibility assessment; design of preclinical study with biomaterials.

Course outcomes

It is expected that the students will have broad knowledge on the science aspects of Biomaterials and its application to human healthcare.

Prerequisites

None.

Additional information

Visit to Laboratory for Biomaterials in batches can be conducted for the interested students. Auditing of the course is discouraged.

Grading policy

To be Updated

Syllabus

To be Updated

Assignments

To be Updated

Resources

  1. Bikramjit Basu; Biomaterials Science and Tissue Engineering: Principles and Methods; Cambridge University Press; ISBN: 9781108415156; 2017.
  2. Bikramjit Basu; Biomaterials for Musculoskeletal regeneration: concepts, Springer Nature; Singapore, 2017 [ISBN: 978-981-10-3058-1 (Print) 978-981-10-3059-8 (Online)]
  3. Bikramjit Basu and Sourabh Ghosh; Biomaterials for Musculoskeletal regeneration: Applications; concepts, Springer Nature; Singapore; 2017 [ISBN: 978-981-10-3016-1 (Print) 978-981-10-3017-8 (Online)]
  4. Biomaterials Science: An introduction to Materials in Medicine, Edited by Ratner, Hoffman, Schoet and Lemons, Second Edition: Elsevier Academic Press, 2004.
  5. Fredrick H. Silver and David L. Christiansen, Biomaterials Science and Biocompatibility, Springer, Piscataway, New Jersey, first edition, 1999.
  6. Janathan Black, Biological Performance of Materials: Fundamentals of Biocompatibility, Marcel Dekker, Inc., New York and Basel, 1999.