Bioengineering and Biodesign Initiative at IISc: Phase 2 (BBI2)

    BBI2 (Bioengineering and Biodesign Initiative at IISc: Phase 2) is a second phase project supported by the Department of Biotechnology (DBT). The first phase of this project brought biology and engineering faculty of IISc come together with a few clinical institutions to work on interdisciplinary research projects in bioengineering and biodesign. It also helped set up a laboratory with critical equipment that facilitated research in bioengineering. It played a role in the establishment of a new department in IISc, viz. BioSystems Science and Engineering (BSSE). While Phase 1 had three bioengineering research projects and three biodesign projects, Phase 2 is a scaled up to include a total of 24 projects of which eight translational biology research projects, six bioengineering projects, and 10 biodesign projects. Additionally, new academic programmes are proposed in BBI2. MD and MS degree holders pursuing design innovation is one such programme. BBI2 will also nurture PhD students in BSSE@IISc by facilitating equipment maintained by two facility technologists, a veterinarian, and a research manager. BBI2 includes nearly 50 investigators and clinicians from 10 hospitals.

    List of BBI2 projects in Phase 2



    1. Biodesign research projects
    2. Sl NumberProjects
      D1A brain-function index apparatus to neurologically evaluate cognition
      D2Pediatric Pneumonia Detection
      D3Neuro-protective Intervention in a Realistic, Neurophysiological model of Stroke in Rats
      D4Intraoperative Ultrasound Tomographic Systems for Guidance in Spinal Surgery
      D5Biopsy Needle Guidance Systems using Micro-acoustic Emitter
      D6Cognitive and Auditory Rehabilitation for Elderly
      D73D Printing of Biomedical Devices
      D8Assistive Technology for Early Diagnosis of Neuro-motor Development Delay and Restriction in Infants
      D9Development of a prototype device incorporating voice and breath sound analysis for quantification and monitoring of asthma
      D10Development of a prototype device for the diagnosis of Obstructive Sleep Apnea using snore derived respiratory signal and pulse oximetry

    People

    • Dr. Gopalkrishna Hegde (Research Manager)
    • Prof. Namrata Gundiah (Translational Research Projects)
    • Prof. Kaushik Chatterjee (Bioengineering Research Projects)
    • Prof. Bikramjit Basu (Biodesign Research Projects)
    • Dr. Seshagiri Gaonkar
    • Dr. Mahesh Jayachandra (Facility Technologist)
    • Anusha (Facility Technologist)
    • Chaitra Rajeevalochana (Secretarial Assistant)
    • To be announced
    • To be announced

    Publications

    • Suman Chatterjee, MansiSaxena, DeepakPadmanabhan, Mahesh Jayachandra, Hardik J. Pandya "Futuristic medical implants using bioresorbable materials and devices", Biosensors and Bioelectronics, 2019, Vol 142, 111489. DOI:10.1016/j.bios.2019.111489

    • Prasoon Kumar, Prashant Agrawal and Kaushik Chatterjee "Challenges and opportunities in blood flow through porous substrate: A design and interface perspective of dried blood spot", Journal of Pharmaceutical and Biomedical Analysis, 2019, Vol 175, 112772. DOI:10.1016/j.jpba.2019.07.020

    • J. Panwar and R. Roy "Integrated Field's metal microelectrodes based microfluidic impedance cytometry for cell-in-droplet quantification", MicroE Engineering, 2019, Vol 215, 111010. DOI:10.1016/j.mee.2019.111010

    • J. Hasan, A. Roy, K. Chatterjee and P.K.D.V. Yarlagadda "Mimicking Insect Wings: The Roadmap to Bioinspiration", ACS Biomaterials Science & Engineering, 2019. DOI:10.1021/acsbiomaterials.9b00217

    • Sharmistha Naskar, V. Kumaran, Bikramjit Basu " Reprogramming the stem cell behaviour by shear stress and electric field modulation: Lab-on-a-chip based applications in regenerative medicine", Regenerative Engineering and Translational Medicine, 2018, 5(2), 99–127. DOI:10.1007/s40883-018-0071-1

    • Sharmistha Naskar, Asish Kumar Panda, Viswanathan Kumaran, Bhupesh Mehta, and Bikramjit Basu "Controlled Shear Flow Directs Osteogenesis on UHMWPE-Based Hybrid Nanobiocomposites in a Custom-Designed PMMA Microfluidic Device", ACS Applied Biomaterials, 2018, 1(2), 414-435. DOI:10.1021/acsabm.8b00147

    • R. Das, A. Mitra, G. Mitra, D. Maity, V. Bhat, D. Pal, C. Ross, A. V. Kurpad and A. K. Mandal "Molecular insights of inhibition in sickle hemoglobin polymerization upon glutathionylation: hydrogen/deuterium exchange mass spectrometry and molecular dynamics simulation-based approach", Biochemical Journal, 2018. DOI:10.1042/BCJ20180306

    • Shivani Yadav, Kausthubha NK, Dipanjan Gope, Uma Maheswari Krishnaswamy, Prasanta Kumar Ghosh "Comparison of Cough, Wheeze and Sustained Phonations for Automatic Classification between Healthy subjects and Asthmatic patients", IEEE international conference Engineering in Medicine and Biology Society (EMBC) 2018, Honolulu, Hawaii, USA.

    • To be posted
    • To be posted
    • To be posted

      Patents

      Title of the invention: MICROFLUIDICDEVICES Filing number is 201841012166. – Rahul Roy

        Devices/Systems Developed

        To be posted

          Events

          • To be posted
          • A joint ISRO-IISc one day workshop on "Space Bioengineering and Life Sciences" was organized at IISc Council Chamber on 27th Oct, 2018. Senior scientists from ISRO, All India Institute of Medical Sciences, University of Agriculture Sciences, Bengaluru and IISc faculties attended the meeting. Participants presented their ongoing research related to Space Bioengineering. The need for joint research in Space Bioengineering and future course of action have been discussed.

          • MedSim 2019: One day workshop on 27th Feb. 2019 at BSSE, IISc
            A one day workshop on "Medical Simulations (MedSim2019)” was organized under BBI2, BSSE at CES Seminar hall on Wednesday, 27th Feb.2019. About 80 medical doctors from different parts of the country have participated in the event. Dr. D.Nageshwara Reddy, Director, Asian Institute of Gastroenterology, gave the keynote address and senior Doctors and Surgeons from different Medical Colleges and well known Hospitals presented their views on state of the art medical simulators currently available, role of simulation in surgery, teaching, training etc. All the presentations and discussions are well received by the participants. The event was concluded with a panel discussion by the team of experts.