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X-WR-CALDESC:Events for Department of Bioengineering
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TZID:Asia/Kolkata
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DTSTART:20250101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20250310T160000
DTEND;TZID=Asia/Kolkata:20250310T170000
DTSTAMP:20260426T152554
CREATED:20250305T043555Z
LAST-MODIFIED:20250305T043555Z
UID:4395499-1741622400-1741626000@be.iisc.ac.in
SUMMARY:BE Seminar\, Pooled Microscopy-Based CRISPR Screens by Dr. Krishna Choudhary
DESCRIPTION:Speaker: Dr. Krishna Choudhary\nPostdoctoral Scholar\, University of California\, San Francisco. \nDate:10th March\nTime: 4.00 PM\nVenue: TCS Smart X Building\, Classroom 03 – (G F – 12) \nTitle: Pooled Microscopy-Based CRISPR Screens \nAbstract: Pooled CRISPR screens have revolutionized the process of identifying genetic targets for drug development. Traditional CRISPR screens typically focus on a single phenotype\, such as cell death. While this has provided valuable insights into gene essentiality and resistance to cell death\, it has generally failed to uncover functional information for most of the genome. Pooled screening lacks the richness of data achievable through microscopy-based phenotypic screens. \nArrayed microscopy-based screens offer more detailed insights into cancer cell states\, such as cell morphology and subcellular protein localization. However\, the challenges associated with executing large-scale arrayed screens and analyzing the resulting images have limited the scalability and accessibility of high-content microscopy-based CRISPR screens. \nIn this talk\, He will present an integrated wet lab and computational platform for pooled microscopy-based CRISPR screens. His technology uses epitope combinations attached to a fluorescent protein to barcode CRISPR guide identities. Combined with multiplexed immunofluorescence microscopy\, which enables the simultaneous quantification of multiple phenotypic markers and CRISPR guide identities at the single-cell level\, this platform allows for the pooling of CRISPR perturbations. By reducing the cost and manual labor requirements\, his work will democratize the use of microscopy-based CRISPR screens\, accelerating therapeutic target discovery and drug development. \nAbout the Speaker: Dr.Krishna is a bioengineer and data scientist with expertise in developing high-throughput technologies that bridge wet lab biology and data science. His published work spans a range of biological systems\, from microbes and RNA viruses to yeast\, neurological disorders\, and cardiovascular disease models. He actively collaborates with diverse biomedical researchers to drive innovations that may translate into impactful therapies and diagnostics for human health. \nDr. Krishna earned his BTech and MTech in Biochemical Engineering and Biotechnology from IIT Delhi (2013). He then completed his Ph.D. at the University of California\, Davis in 2019\, where his research focused on developing statistical methods for the analysis of high-throughput sequencing-based RNA structurome profiling data. Following his PhD\, Krishna worked as a bioinformatician/statistician at the Gladstone Institutes\, San Francisco\, where he gained experience with diverse sequencing-based assays and single-cell technologies. In 2021\, he began postdoctoral training at the University of California San Francisco\, where he expanded his research skill set in the wet lab\, gaining expertise in synthetic biology\, CRISPR technologies\, and high-content microscopy. \nIn the future\, Dr. Krishna aims to continue exploring the genetic basis of complex diseases\, with a focus on developing precision therapies and novel diagnostic tools. His interdisciplinary training in both computational and experimental approaches positions him to make meaningful contributions to the field of bioengineering and data-driven healthcare innovation.
URL:https://be.iisc.ac.in/event/be-seminar-pooled-microscopy-based-crispr-screens-by-dr-krishna-choudhary/
LOCATION:IDR Building – G12: Classroom 3
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20250312T160000
DTEND;TZID=Asia/Kolkata:20250312T170000
DTSTAMP:20260426T152554
CREATED:20250305T043704Z
LAST-MODIFIED:20250305T043704Z
UID:4395501-1741795200-1741798800@be.iisc.ac.in
SUMMARY:BE Seminar: Dynamical Complexity in Microbial Matter by Dr. Praneet Prakash
DESCRIPTION:Speaker: Dr. Praneet Prakash\,\nPostdoctoral Researcher\, University of Cambridge\, UK. \nDate: 12th\, March\nTime: 4.00 PM\nVenue: TCS Smart X Building\, Classroom No.3 (GF -12). \nTitle: Dynamical Complexity in Microbial Matter \nAbstract: Microorganisms inhabit highly fluctuating natural environments and survive in a low-nutrient resource bath. It is now well-recognized that nutrient exchanges among microbes play a vital role in their survival. The existence of such exchanges raises fundamental questions about the dynamics of these interactions. \nIn this talk\, he will explore experimentally and theoretically a realization of such interactions in which active bacteria dynamically respond to the oxygen produced by immotile green algae through photosynthesis. Even in this simplest mixture of active-passive suspensions\, we find complex dynamics involving nutrient exchanges. \nToward the end of the talk\, he will briefly discuss our investigations on the collective behaviour of a living fluidic network\, which presents another fascinating example of dynamical complexity in microbial matter. \nAbout the Speaker: Dr. Praneet Prakash received PhD from the Indian Institute of Science\, Bangalore\, and is currently a postdoctoral researcher at the School of Physical Sciences\, University of Cambridge. His research interests include Microbial Biophysics\, Biofluids\, and Complex Living Systems.
URL:https://be.iisc.ac.in/event/be-seminar-dynamical-complexity-in-microbial-matter-by-dr-praneet-prakash/
LOCATION:IDR Building – G12: Classroom 3
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20250313T140000
DTEND;TZID=Asia/Kolkata:20250313T150000
DTSTAMP:20260426T152554
CREATED:20250311T070224Z
LAST-MODIFIED:20250311T070224Z
UID:4395505-1741874400-1741878000@be.iisc.ac.in
SUMMARY:BE Seminar: Harnessing Nanoscale Cellular Communication for Designing Next-Generation Therapeutics by Dr. Tanmoy Saha\,
DESCRIPTION:Speaker: Dr. Tanmoy Saha\, MSc\, PhD. \nInstructor\, Harvard Medical School \nAssociate Bioengineer\, Brigham and Women’s Hospital \nDate: 13th March\nTime: 2.00 PM\nVenue: TCS Smart X Building\, Seminar Hall – (G F – 22) \nTitle: Harnessing Nanoscale Cellular Communication for Designing Next-Generation Therapeutics \nAbstract: Aberrant intercellular communication underlies disease progression. For example\, cancer cells communicate with neighboring cells to exchange organelles\, proteins\, metabolites\, and ions\, which helps them gain survival advantages. He is interested in three different types of communication: (i) transmembrane ionic communication\, (ii) extracellular protein-mediated communication\, and (iii) intercellular nanoscale physical communication. \nCells maintain an ionic homeostasis with the extracellular environment using ion channels and transporters. He has developed a variety of unimolecular and supramolecular artificial chloride channels (ACT). The ACTs are robust supramolecular architecture made up of small molecules. This helps in a better understanding of ion transport activity and modulating ionic communication in cells. He has performed structure-activity relationships to identify the best ACT. He introduced the first-ever example of ACT\, which can induce apoptosis in cancer cells by disrupting ionic homeostasis. \nCancer cells use extracellular proteins\, known as immune checkpoints\, to send kill-me-not signals to T cells and macrophages. Immunotherapy has made a paradigm shift in cancer treatment by blocking such interactions using monoclonal antibodies. However\, more than 70% of cancer patients do not respond to immunotherapy. He has introduced immunoengineered nanotherapeutics that serve as a platform technology to deliver a combination of pharmacological drugs and biologics to cancer cells. This nanotherapeutic can block more than one immune checkpoint and activate both innate and adaptive immunity. This has shown increased therapeutic efficacy in syngeneic lung cancer\, which is not responsive to traditional immunotherapy and monotherapies. \nFurthermore\, they investigated a novel mechanism of immune evasion by cancer cells through nanoscale physical communication. They have used high-resolution electron and optical microscopy to identify the nanoscale communication of the cancer cells with T cells and hijack mitochondria. The transfer of mitochondria metabolically empowers the cancer cells and increases their proliferation\, metastasis\, and drug resistance. In contrast\, the T cell population depletes because of metabolic deactivation. Blocking the nanotube-mediated mitochondria transfer by pharmacological inhibitors has shown potential therapeutic implications in increasing intrinsic T cell immune response and elevating therapeutic efficacy in combination with traditional immunotherapy. Moreover\, they have shown elevating the immune response by supercharging T cells with exogenous mitochondria. Hence\, a mechanistic understanding of cellular communication and novel therapeutic strategies are critical to offer better therapeutic outcomes in cancer and other chronic diseases. \nAbout the Speaker: Dr. Saha is an entry-level faculty at Harvard Medical School and an Associate Bioengineer at Brigham and Women’s Hospital. He has received PhD from the Indian Institute of Science Education and Research Pune and received the best thesis award from the chemistry department. Dr. Saha’s. major research direction is to develop tools to study cellular communication and introduce novel therapeutic strategies. He has published his research in prestigious journals\, including Nature Nanotechnology\, Science Advances\, J. Am. Chem. Soc.\, Cell\, PNAS\, etc. He has received independent research grants from the Department of Defense and Melanoma Research Alliance.
URL:https://be.iisc.ac.in/event/be-seminar-harnessing-nanoscale-cellular-communication-for-designing-next-generation-therapeutics-by-dr-tanmoy-saha/
LOCATION:TCS Smart-X Hub Building\, IISc
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20250313T160000
DTEND;TZID=Asia/Kolkata:20250313T170000
DTSTAMP:20260426T152554
CREATED:20250311T070053Z
LAST-MODIFIED:20250311T070053Z
UID:4395503-1741881600-1741885200@be.iisc.ac.in
SUMMARY:BE Seminar: Modeling complex phenotypes supported by gene regulatory networks by Dr. Tomas Gedeon
DESCRIPTION:Speaker: Dr. Tomas Gedeon\nDate: 13th March\nTime: 4.00 PM\nVenue: TCS Smart X Building\, Classroom 03 – (G F – 12) \nTitle: Modeling complex phenotypes supported by gene regulatory networks \nAbstract: Gene regulatory networks with more than a few genes can support different phenotypes in different conditions. These conditions may be external inputs like intercellular signaling\, resource abundance\, or internal variability like abundance of ribosomes\, RNAP\, or even copy number of different enzymes. The different conditions can be modeled as changes in the parameters of a gene network model. \nThe mathematical challenge is to develop methods to describe\, search\, and analyze the behavior of models across large sets of parameters. He will illustrate the use of the techniques that we developed\, which are based on combining discrete Boolean approaches with differential equations models\, on three problems: \nThe first problem studies a problem where naive CD4+ cells differentiate into Th1\, Th2\, Th17\, and Treg subsets which mutually inhibit each other. in their model\, they compare the prevalence\, across all parameters\, of a fully differentiated cell type to a cell type that combines characteristics of two of the four types. They find that such a type of hybrid occurs\nmore frequently. This suggests that differentiation to four types likely happens in a two-step process\, rather than in a single step. The model is general and conclusions may apply to other differentiation processes. \nThe second problem concerns the ability of the same cell cycle network in yeast to support two phenotypes: (a) regular cell cycle\, and (b) endocycling\, where the cell duplicates the genome but does not go through mitosis. Endocycling can be induced experimentally by knocking down mitotic cyclin and they use the data to show that\, indeed\, a single network in different parameter regimes\, can support these different phenotypes. \nThe third problem concerns the gap gene network in Drosophila. Maternal gradients provide cell-specific input into the gap gene network along the head-to-tail axis. They investigate if this varying input\, interpreted as varying specification of parameters of the gap gene network\, is sufficient to explain different states that the network reaches in different segments\, which lays down the segmentation plan for the animal. \nIf interest and time remain\, He will explain a bit of the mathematics that allows us to do this type of analysis. \nAbout the Speaker: Dr. Tomas Gedeon is a Professor of Mathematics at Montana State University who specializes in mathematical modeling of biological systems\, especially those arising in cellular and molecular biology. His most recent interest is to develop new methods to understand the behavior of gene regulatory networks with applications to apply understanding of cell cycle and behavior of developmental networks across time and space. He obtained his undergraduate degree from Comenius University in his native Slovakia in 1989 and a PhD in Mathematics from Georgia Institute of Technology in 1994.
URL:https://be.iisc.ac.in/event/be-seminar-modeling-complex-phenotypes-supported-by-gene-regulatory-networks-by-dr-tomas-gedeon/
LOCATION:IDR Building – G12: Classroom 3
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20250321T160000
DTEND;TZID=Asia/Kolkata:20250321T170000
DTSTAMP:20260426T152554
CREATED:20250320T045937Z
LAST-MODIFIED:20250320T045937Z
UID:4395507-1742572800-1742576400@be.iisc.ac.in
SUMMARY:BE Seminar: BioMedical Printing Technology – from Vascularized OOCs to Cellular Agriculture by Dr. Andreas Blaeser
DESCRIPTION:Speaker: Dr. Andreas Blaeser\nDate: 21st March\nTime: 4.00 PM\nVenue: TCS Smart X Building\, Classroom 03 – (G F – 12) \nTitle: BioMedical Printing Technology – from Vascularized OOCs to Cellular Agriculture \nAbstract: The field of biomedical printing encompasses various techniques for the bio fabrication of living tissue. Among these\, 3D bioprinting is the best known. It is used to print living cells embedded in a hydrogel precursor in layers to form a three-dimensional tissue precursor. These can be further developed into biological implants for regenerative medicine (bone\, muscle\, cartilage) or processed into miniaturised in vitro models for drug testing (e.g. organ-on-a-ship systems). The lecture will give a brief overview of existing bioprinting methods and also discuss novel printing mechanisms for the large-scale production of cellular agriculture products (e.g. cultured meat). Finally\, a link will be made to industrial printing by presenting a newly developed 3D printing system for the production of comparatively light components for bioinspired architecture and design. \nAbout the speaker: Andreas Blaeser is a professor of “BioMedical Printing Technology” at the Technical University of Darmstadt in Germany and Director of the Institute for Printing Science and Technology (IDD). He conducts research in the field of bio fabrication\, production and joining technology of biologized functional materials. In this role\, he leads and develops an interdisciplinary team of scientists and teaches interdisciplinary subjects on Biomaterials\, Tissue Engineering\, Bio fabrication\, and 3D-Bioprinting Technology as part of the master programs “Mechanical and Process Engineering”\, and “Synthetic Biology” as well as in the Bachelor program “Bio-Materials Engineering”. The focus of his research and teaching is on bringing together living cells\, hydrogels\, and engineering materials with special mechanical\, chemical\, and electrical properties. His work provides the basis for the future production of bioartificial tissues\, “sentient” robotics\, and renewable semi-finished products. These can be used\, for example\, as implants in regenerative medicine\, as sensor-integrated in vitro models for drug and toxicity studies\, as artificial skin of soft robotics elements\, or as sustainable bioartificial consumer goods (e.g. cultured meat).
URL:https://be.iisc.ac.in/event/be-seminar-biomedical-printing-technology-from-vascularized-oocs-to-cellular-agriculture-by-dr-andreas-blaeser/
LOCATION:IDR Building – G12: Classroom 3
CATEGORIES:Seminar
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