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BEGIN:VEVENT
DTSTART;TZID=UTC:20240304T160000
DTEND;TZID=UTC:20240304T170000
DTSTAMP:20260406T041611
CREATED:20240227T230448Z
LAST-MODIFIED:20240227T230448Z
UID:4394612-1709568000-1709571600@be.iisc.ac.in
SUMMARY:BE Seminar: A Mathematical Odyssey: From Brain Biomechanics to Cancer Therapeutics
DESCRIPTION:Speaker: Dr Siv Sivaloganathan \nTitle: A Mathematical Odyssey: From Brain Biomechanics to Cancer Therapeutics \nAbstract: In this talk\, I will touch on some of the successes and obstacles encountered in the application of mathematics to the biomedical sciences. I hope to illustrate this with examples from hydrocephalus\, tumorigenesis\, and the utilization of High-Intensity Focused Ultrasound (HIFU) for cancer treatment. Mathematical models have proven instrumental in optimizing hydrocephalus treatments\, and helped unveil some of the intricacies of tumor development and treatment response. Moreover\, they continue to play a major role in the evolution of non-invasive HIFU as a strategy for cancer therapeutics. These examples underscore the profound impact of mathematical modeling in understanding physiological dysfunction and shaping effective interventions in clinical medicine. \nAbout The Speaker: Dr. Siv Sivaloganathan is a Professor at the Department of Applied Mathematics\, University of Waterloo\, and heads the Biomedical Research Group there. Since 2004\, he is also the Director of the Centre for Mathematical Medicine at Fields Institute in Toronto. He obtained his PhD from Oxford University\, and has extensively trained multiple PhD students and postdoctoral fellows in mathematical biology in past 25 years. His expertise is in the field of biomechanics and the development of mathematical models of clinical conditions and diseases using continuum mechanics. He has been Principal Investigator on a number of grants including NSERC Collaborative Health and Hospital for Sick Children Foundation. \n 
URL:https://be.iisc.ac.in/event/be-seminar-a-mathematical-odyssey-from-brain-biomechanics-to-cancer-therapeutics/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20240212T160000
DTEND;TZID=UTC:20240212T170000
DTSTAMP:20260406T041611
CREATED:20240205T224249Z
LAST-MODIFIED:20240205T224249Z
UID:4394573-1707753600-1707757200@be.iisc.ac.in
SUMMARY:BE Seminar : Extracellular Matrix- A Transport Barrier for Drug Delivery
DESCRIPTION:Speaker: Dr. Rashmi Mohanty \nTitle: Extracellular Matrix- A Transport Barrier for Drug Delivery \nAbstract: Extracellular Matrix (ECM) determines crucial cellular responses through cell-matrix interactions. Specific qualitative and quantitative changes occur in the ECM during disease and\, in part\, regulate critical events that determine pathological tissue phenotype. For example\, in solid cancers\, the extraordinarily dense fibrotic ECM is primarily responsible for the increased interstitial tissue pressure and stiff mechanical properties. The resulting dense stroma impedes the transport of therapeutic anticancer drugs\, limiting effective drug delivery and\, therefore\, the therapeutic potential of drug candidates. To overcome the tumor ECM drug delivery barrier\, during my PhD\, I leveraged favorable surface physicochemical interactions between the tumor ECM and drug carriers to enhance the delivery and\, hence\, the therapeutic outcomes of antitumor drugs. I used genetically engineered peptide-presenting phage libraries as a high-throughput approach to screen and identify peptide coatings that would facilitate improved transport through the tumor microenvironment. Interestingly\, in contrast to most studies\, I found that a positively charged peptide “surface” enhanced penetration\, uptake\, and retention of particles in tumor tissue when compared to neutrally charged peptides. Next\, I conjugated the peptide to immune checkpoint inhibitor antibodies\, which\, in a murine melanoma tumor environment\, recruited a higher number of activated tumor-infiltrating T-cells\, resulting in delayed tumor growth. \nHaving worked with cell culture\, ex vivo tissue culture\, and animal model development during my Ph.D.\, I realized there is an unmet gap in developing models that can more easily recapitulate the dynamic and transport features of disease. Believing that the emerging\, complex multicellular 3D organoid systems would more accurately reflect the human physiological environment\, I joined the Weiss lab for my postdoctoral study to implement synthetic biology tools for organoid design. Currently\, I am working on recapitulating the native-like organ architecture in liver organoids by mimicking the honeycomb-like patterns in human livers. Combining synthetic biology\, micro-robotics\, and machine learning\, we deliver biological cues at precise locations to control the differentiation of human-induced pluripotent stem cells (hiPSCs) in a spatiotemporal fashion. \nAlthough organoids have emerged as the next-generation tool for disease modeling and drug screening\, the formation of matured organoids remains a challenge\, partly because the current models lack the natural context of endogenous cell-governing ECM secretion and assembly formation. In my future research program\, I will employ synthetic biology principles to genetically engineer hiPSCs to secrete relevant ECM (as occurs in vivo) for designing tailor-made disease-specific organoids to investigate drug transport and drug delivery with an aim to accelerate the drug development pipeline. \nAbout the speaker: Dr. Rashmi Mohanty is am a postdoctoral associate in the Department of Biological Engineering at the Massachusetts Institute of Technology. My current work focuses on employing synthetic biology tools to control cell fate decisions for the formation of programmable organoids. She has completed Ph.D. in the College of Pharmacy at the University of Texas at Austin (UT). During Ph.D.\, she worked on developing therapeutic moieties that can overcome the transport barrier of the tumor microenvironment for improved drug delivery. Prior to matriculating at UT\, she received my Bachelor of Technology in Chemical Engineering from the National Institute of Technology (NIT) Rourkela and my Master of Technology in Chemical Engineering from the Indian Institute of Technology (IIT) Kanpur. Building from my knowledge and gained experiences with the limitations of current models used to recapitulate stroma-rich disease environments\, in the long run\, she is interested in designing 3D models that better reflect various disease environments to accelerate the progress of disease diagnostics and drug discovery.
URL:https://be.iisc.ac.in/event/be-seminar-extracellular-matrix-a-transport-barrier-for-drug-delivery/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20240205T160000
DTEND;TZID=UTC:20240205T170000
DTSTAMP:20260406T041611
CREATED:20240128T235733Z
LAST-MODIFIED:20240128T235733Z
UID:4394472-1707148800-1707152400@be.iisc.ac.in
SUMMARY:BE Seminar: Drug Delivery across Biological Barriers for combatting and preventing infectious diseases
DESCRIPTION:  \nTitle: Drug Delivery across Biological Barriers for combatting and preventing infectious diseases. \nProf. Dr. Claus-Michael Lehr \nHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)\, Helmholtz Center for Infection Research (HZI) Dept of Drug Delivery. and \nSaarland University\, Dept of Pharmacy\, \nSaarbrücken\, Germany. \nAbstract: Urgently needed anti-infective drugs and vaccines must reach their targets safely and efficiently. Not only the body’s outer epithelia\, like e.g.\, gut\, skin and lung\, but also the bacterial cell envelope as well as the polymer matrix of bacterial biofilms represent important biological barriers which may delimit the transport of anti-infectives to their site of action (“bacterial bioavailability”). \nTo model the air-blood barrier of the peripheral human lung\, our group was the first who published a protocol for growing monolayers of human alveolar epithelial cells in primary culture (hAEpC) to develop functional tight junctions and high transepithelial electrical resistance (TEER). Later we introduced a first polyclonal human alveolar epithelial (hAELVi) and just recently a monoclonal cell line (Arlo) with similar properties. These epithelial cells may be implemented in various micro-physiological systems\, also to study the effect of breathing and co-cultivated with other cells types\, like e.g.\, macrophages or endothelial cells. A particular challenge is the mixed culture with bacterial biofilms to model chronic lung infections\, which can meanwhile be realized most elegantly by 3D bioprinting. \nSuch complex in-vitro models aim to reflect the (patho)physiology of specific organs or tissues either in healthy or reduce diseased state and to generate clinically meaningful readouts. They have been used for developing novel anti-infectives\, like e.g.\, quorum sensing inhibitors\, aiming to eradicate pathogens without inducing antimicrobial resistance. Aerosolizable nano-antibiotics are also being investigated to combat intracellular infections\, such as e.g.\, tuberculosis or viral infections by Crispr/CAS-like approaches. \nAbout The Speaker: Claus-Michael Lehr is Professor at Saarland University as well as cofounder and head of the department “Drug Delivery and Biological Barriers” at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\, which was established as a branch of the Helmholtz Centre for Infection Research (HZI) Braunschweig in 2009. Prof. Lehr has also been cofounder of Across Barriers GmbH and of PharmBioTec GmbH\, a non-for-profit contract research organization. \nThe research theme of Professor Lehr’s team is (preferentially: non-invasive) drug delivery across biological barriers\, in particular the epithelia of the gastrointestinal tract\, the skin\, and the lungs. Recently\, this has been expanded to microbial barriers\, such as the bacterial cellular envelope\, biofilms and host cell membranes. A substantial part of the lab’s activities is dedicated to innovative carrier’s systems\, often based on nanotechnology\, capable of safely and efficiently delivering drugs and vaccines across these barriers. In this context\, the lab systematically investigates predictive cells and tissue models\, preferentially human-based\, to evaluate the safety and efficacy of novel therapeutic concepts and to facilitate their translation into the clinic.
URL:https://be.iisc.ac.in/event/be-seminar-drug-delivery-across-biological-barriers-for-combatting-and-preventing-infectious-diseases/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20240131T160000
DTEND;TZID=UTC:20240131T170000
DTSTAMP:20260406T041611
CREATED:20240123T224407Z
LAST-MODIFIED:20240123T224407Z
UID:4394470-1706716800-1706720400@be.iisc.ac.in
SUMMARY:BE Seminar: Living Therapeutic Materials – Hydrogel encapsulated bacteria for smart drug delivery
DESCRIPTION:Speaker: Dr. Shrikrishnan Sankaran \nTitle: Living Therapeutic Materials – Hydrogel encapsulated bacteria for smart drug delivery \nAbstract: Living therapeutics is a rapidly growing field in which live microorganisms are engineered to produce and deliver drugs right within the body. A unique advantage of this approach is that the organisms can be programmed with smart functions to sense and process disease-associated stimuli from the patient and regulate the drugs they produce. Probiotic or host-friendly bacteria engineered to sense patients’ needs and deliver drugs in response are showing early promise in treating chronic diseases but two major challenges are slowing progress of this approach – (i) scarcity of genetic tools to program sensing functions in most medically relevant probiotics like lactobacilli & (ii) unpredictability of drug doses due to variable bacterial survival in the body. In this presentation\, I will share my group’s multi-disciplinary approach to overcome these challenges by (i) expanding the poorly equipped genetic toolbox of probiotic lactobacilli with new gene regulatory and plasmid retention modules[1]. and (ii) encapsulating the bacteria in mechanically tunable hydrogels that can controllably sustain bacterial activity[2\,3]. The engineered bacteria combined with hydrogels form living therapeutic materials\, in which control over bacterial functions can be exerted through both genetic and mechanical means. Novel fundamental insights and application-oriented advances from our published and ongoing work will be presented. \nAbout the Speaker: Dr. Shrikrishnan Sankaran is the head of the Bio programmable Materials research group\, he combines bacterial engineering with biomaterials to develop engineered living materials for therapeutic and environmental applications. His group genetically programs beneficial bacteria with sensing\, catalytic and therapeutic functions. These bacteria are encapsulated in soft materials like hydrogels to create living devices that perform these advanced functions long-term at low-costs and in an eco-friendly manner. Currently\, a major focus of the group is expanding the genetic toolkit of non-model probiotic and commensal bacteria to achieve in situ controllable drug delivery.
URL:https://be.iisc.ac.in/event/be-seminar-living-therapeutic-materials-hydrogel-encapsulated-bacteria-for-smart-drug-delivery/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20240123T110000
DTEND;TZID=UTC:20240123T120000
DTSTAMP:20260406T041611
CREATED:20240121T211655Z
LAST-MODIFIED:20240121T211655Z
UID:4394460-1706007600-1706011200@be.iisc.ac.in
SUMMARY:BE Seminar on A dual-fluorescent reporter to identify mechanisms regulating the epithelial-to-mesenchymal transition in breast cancer
DESCRIPTION:Speaker: Prof. Michael Toneff\, PhD\, Departments of Biology and Biochemistry\, Widener University. \nTitle: A dual-fluorescent reporter to identify mechanisms regulating the epithelial-to-mesenchymal transition in breast cancer. \nAbstract: The epithelial-mesenchymal transition (EMT) is a developmental and wound-healing process whereby stationary epithelial cells undergo a reversible phenotypic change to a motile\, mesenchymal-like state. EMT can aberrantly occur in carcinoma cells and is strongly linked to therapeutic resistance. Moreover\, the ability of carcinoma cells to exhibit plasticity between epithelial and mesenchymal states may be critical for carcinoma cells to adapt to the different stages of metastatic progression. E-cadherin is an effector of the epithelial phenotype\, and its expression is lost during EMT. ZEB1 is a transcription factor that promotes EMT via repression of E-cadherin and other epithelial genes. We developed a lentivirus-based\, dual-fluorescent reporter that reflects the state of E-cadherin transcription and ZEB1 post-transcriptional regulation by the microRNA 200 family. This dual reporter enables the real-time identification of live cells in an epithelial\, mesenchymal\, or hybrid state\, thus facilitating the study of the dynamic EMT phenomenon. Using this reporter\, we identified several compounds that can reverse the mesenchymal phenotypes associated with poor breast cancer outcomes. Furthermore\, we have identified epigenetic mechanisms\, including DNA methylation and histone acetylation\, as potentially critical determinants of complete vs. partial EMT states. In this talk\, I will discuss how we have used our reporter to better understand how breast cancer cells achieve aggressive mesenchymal properties and to identify potential therapeutic targets to better treat this deadly disease. \nBiography: Dr. Michael Toneff received his BS in Biology at Ohio State University in Columbus\, Ohio where he became interested in someday teaching biology to undergraduates and performing cancer research. He moved to Houston\, Texas and received his PhD at Baylor College of Medicine (BCM) in the laboratory of Dr. Yi Li\, where he studied the hormone dependency of breast cancer initiation. Dr. Toneff was then awarded the NIH-funded IRACDA Postdoctoral Fellowship that combined post-doctoral research with teaching at minority-serving undergraduate institutions. Dr. Toneff joined the laboratory of Dr. Jeffrey Rosen at BCM as an IRACDA fellow. In the Rosen laboratory\, he studied the epithelial-mesenchymal transition (EMT) in breast cancer where he developed the Z-cad dual fluorescent reporter to identify the EMT state of live cells. It was during this time that he first identified epigenetic mechanisms as a determinant of EMT states in breast cancer. During this time\, he also taught several cell and molecular biology courses at the University of Houston-Downtown. Dr. Toneff is currently an Associate Professor of Biology at Widener University\, a primarily undergraduate teaching institution just outside of Philadelphia\, Pennsylvania. At Widener\, he teaches both introductory and upper division cell and molecular biology courses. Moreover\, he has continued to study EMT regulatory mechanisms in collaboration with others\, including Dr. Mohit Jolly at IISc\, while training undergraduate students in his research laboratory.
URL:https://be.iisc.ac.in/event/be-seminar-on-a-dual-fluorescent-reporter-to-identify-mechanisms-regulating-the-epithelial-to-mesenchymal-transition-in-breast-cancer/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20240118T140000
DTEND;TZID=UTC:20240118T150000
DTSTAMP:20260406T041611
CREATED:20240115T234106Z
LAST-MODIFIED:20240115T234106Z
UID:4394455-1705586400-1705590000@be.iisc.ac.in
SUMMARY:BE Seminar titled Employing Common Ions And Molecules For Sustainable Clean Water by Dr. Swathy J. R.
DESCRIPTION:Title: EMPLOYING COMMON IONS AND MOLECULES FOR SUSTAINABLE CLEAN WATER \nSpeaker: Dr. Swathy J. R. \nAbstract: Despite the existence of several innovative solutions in the field of water purification\, successful technologies continue to encounter significant challenges. Many of these technologies lack sustainability and durability due to frequent manual interventions and associated expenses. While various global entities\, both governmental and non-governmental\, are striving to provide clean water to those in need and are evaluating the water demand in the context of climate change\, industries are struggling to find alternative options that are stable\, cost-effective\, uninterrupted\, and reliable to address this critical issue. For these technologies to achieve sustainability and widespread adoption\, they must not only be energy-efficient\, rapid\, and affordable\, but also environmentally benign. \nThe objective of the presentation is to emphasize the synergistic effects of ions on biological systems and discuss the design of materials that can sustainably release both anions and cations. The talk will present the use of carbonates as one of the dimension to counteract cytotoxicity induced by arsenic. Additionally\, insights into the application of ambient mass spectrometry as a tool for detecting biofouling on water purification materials will be shared during this session. \nBiography: Dr. Swathy is a proactive researcher with an industrial exposure and holds her interdisciplinary doctoral degree from IIT MADRAS under the guidance of Padmashri. Prof. T. Pradeep (Chemistry)\, Prof. Ligy Philip (Civil Engr.) on the topic\, “Employing Common Ions and Molecules for Sustainable Clean Water”. Further\, she is now heading the Validation wing at R&D\, Eureka Forbes Limited\, monitoring technology development\, institutional collaborations\, bench-marking and field trial data processing. She drives open innovation and is a part of cross functional ratification team to develop robust strategies to support product applications. \nShe has a demonstrated history of technology transfer and application oriented research related to drinking water purification. Swathy’s research interests are in water chemistry & microbiology interface focusing on commercially viable and environmentally benign advanced materials\, their Ionic interaction in water\, and its analytical perspectives. Her work experience includes design\, development\, optimization\, scale-up and ratification of commercial water purification technologies to address water pollution around the world. Analytical expertise to understand the performance of technologies and designing digital water monitoring systems are some of her highlighted deliveries. \nShe has 16+ Indian\, US and WIPO patents and 10 high impact research publications in peer reviewed journals (Total impact factor of 81.6)\, in the area of sustainable solutions for drinking water purification. Her recent work on reducing the water wastage from Reverse osmosis technology has been incorporated into the Aquaguard® products under the names Aquaguard® Crystal NXT HR RO+UV+MTDS and Aquaguard® Aura HR RO+UV+MTDS\, and are successful in the Indian market with diverse water conditions for the past 2 years. \nShe has also been elected as a talent to represent SDG – 6 (water)\, by the UNLEASH global community. She is a part of sustainability development team at Eureka Forbes Limited\, for handling the corporate’s sustainability projects. She is presently serving as a subject matter expert in industry’s pollution control committee. \nHer patented work titled ‘Anion effect on disinfection of silver’ was sold to a “US based Nanoholding Inc.\, a Delaware corporation” for its commercialization. Her work titled “Rollpure”\, a rolling water purifier won the prestigious Gandhian Young Technological Innovation (GYTI) Award from the honorable President of India.
URL:https://be.iisc.ac.in/event/be-seminar-titled-employing-common-ions-and-molecules-for-sustainable-clean-water-by-dr-swathy-j-r/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20231009T160000
DTEND;TZID=UTC:20231009T170000
DTSTAMP:20260406T041611
CREATED:20231003T233354Z
LAST-MODIFIED:20231003T233354Z
UID:4394278-1696867200-1696870800@be.iisc.ac.in
SUMMARY:Seminar by Dr. Mahipal Ganji on "Decoding the Stabilizing Energetics of DNA and Their Applications in DNA Nanotechnology and Super-resolution Imaging"
DESCRIPTION:The Department of Bioengineering (BE) cordially invites you to attend a Departmental Seminar. \nSpeaker: Dr. Mahipal Ganji\nDepartment name: Dept. of Biochemistry\, IISc. \nTitle: Decoding the Stabilizing Energetics of DNA and Their Applications in DNA Nanotechnology and Super-resolution Imaging \nAbout the Speaker: Mahipal studied Physics at Nizam College Hyderabad\, India\, and Nanobiophysics at TU Dresden\, Germany\, followed by a PhD from Bionanoscience department at TU Delft\, the Netherlands. After short stint as postdoc at the same institute\, did a postdoctoral work at the Max-Planck Institute of Biochemistry\, Martinsried Germany. His research is interested in understanding how genome is organized in a small compartment. We develop tools to understand factors that alter genome organization using single-molecule imaging and super-resolution microscopy approaches. \nAbstract:\nIn the realm of biology\, DNA within our cells constantly undergoes deformations\, unwinding and rewinding\, yet remarkably\, genetic information is efficiently passed down through generations. In my talk\, I will delve into our recent endeavors aimed at unraveling the world of stabilizing energetics within DNA. Specifically\, we have developed an innovative multiplexed single-molecule assay\, harnessing the power of DNA-PAINT super-resolution imaging and DNA nanotechnology. This advanced imaging technology enables us to conduct unbiased kinetic analyses of multiple stacking interactions in a single experiment. Our data reveals that the stability of individual dinucleotide interactions varies dramatically\, allowing us to implicate them in diverse applications. During my presentation\, I will explore their implications in understanding the mechanical properties of single-stranded DNA. Furthermore\, I will discuss how these discoveries are paving the way for the development of efficient imaging probes and their relevance to the field of DNA nanotechnology.
URL:https://be.iisc.ac.in/event/seminar-by-dr-mahipal-ganji-on-decoding-the-stabilizing-energetics-of-dna-and-their-applications-in-dna-nanotechnology-and-super-resolution-imaging/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230904T160000
DTEND;TZID=UTC:20230904T170000
DTSTAMP:20260406T041611
CREATED:20230830T003702Z
LAST-MODIFIED:20230830T003702Z
UID:4394192-1693843200-1693846800@be.iisc.ac.in
SUMMARY:Seminar by Dr. Praveen Kumar Vemula on "Biometerials and Chemical Biology Approaches for Solving Unmet Clinical Needs"
DESCRIPTION:Title:   Biomaterials and Chemical Biology Approaches for Solving Unmet Clinical Needs \nSpeaker: Dr. Praveen Kumar Vemula\nFaculty In Stem\,\nBangalore. \n About the Speaker: Dr. Praveen Kumar Vemula is an Associate Professor at the Institute for Stem Cell Science and Regenerative Medicine (in-Stem)\, Bangalore. He has completed Masters in Chemistry from Osmania University\, and obtained PhD from Indian Institute of Science\, Bangalore. His expertise is developing chemical technologies for medical applications. His work spans the fields of biomaterials\, drug discovery\, drug delivery\, medical devices\, and chemical biology. He has published >85 peer-reviewed papers\, has given >200 national and international invited lectures including two TEDx talks\, and has >30 issued or pending national/international patents\, which have been licensed to multiple biotech companies. Several technologies developed in his lab have formed the foundation for multiple products on the market\, and currently under development. His technologies have led to the launch of seven startup companies. Thus far\, >20 products that are developed based on his technologies are in the market worldwide. \nAbstract: Our lab is focusing on clinical translational research through biomaterials and chemical biology programs. By using chemical design tools\, we have been developing therapeutic and prophylactic biomaterials for medical applications. For example\, in this talk two specific examples will be discussed in detail. In one example\, we will discuss development of potential drugs for the treatment of inflammatory bowel diseases using biomimicry-based drug discovery. In another example\, we will discuss developing a novel blood bag technology to enhance the quality and shelf-life of stored blood that will have enormous clinical implication. Overall\, we will see a snapshot of various technologies that could be developed in the lab and translated into the clinic/market.
URL:https://be.iisc.ac.in/event/seminar-by-dr-praveen-kumar-vemula-on-biometerials-and-chemical-biology-approaches-for-solving-unmet-clinical-needs/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230814T160000
DTEND;TZID=UTC:20230814T170000
DTSTAMP:20260406T041611
CREATED:20230810T054142Z
LAST-MODIFIED:20230810T054142Z
UID:4394174-1692028800-1692032400@be.iisc.ac.in
SUMMARY:Seminar by Dr. Sunil Laxman on “Economic principles of metabolic restoration in cells”
DESCRIPTION:Speaker: Dr. Sunil Laxman\, Associate Investigator\, DBT-in Stem\, Bangalore        \nTitle:    Economic principles of metabolic restoration in cells  \n About the Speaker: Sunil Laxman is an associate investigator at DBT-in Stem\, Bangalore. An old Bangalorean\, Sunil completed his BTech at CBT\, AU in Chennai\, and a Ph.D. at the University of Washington\, Seattle (with Prof. Joseph Beavo)\, where he developed an interest in principles of cell signaling. He went on to postdoctoral studies at UT Southwestern Medical Centre\, with Profs. Steven McKnight and Benjamin Tu\, which initiated interest in metabolism. The current goals of research in the Laxman lab are to identify the rules\, chemical logic\, and organizational principles of metabolic networks. Ongoing directions of research include understanding the formation and sensing of metabolites\, and systems-level principles of metabolic network organization. \nAbstract: Cell metabolism should be thought of as an economy\, which is organized into supply and demand blocks (of precursors and products). But to build frameworks for metabolic exchange between cells\, and how the evolution of metabolic/signalling pathways determines resource allocation strategies in cells. Findings from these studies are being integrated synthetic systems approaches for regenerative biology\, food\, and environmental biotechnology. The lab is supported by a DBT-Wellcome India Alliance Senior Fellowship\, and other support from DST\, DBT\, and the EMBO YIP/Global Investigator network. what can supply-demand analysis teach us? Quantitative considerations of supply and demand should reveal multiple organizations of cellular responses. I will explore this central concept in this seminar\, through two ongoing studies. In the first\, we address how cells differentially prioritize the restoration of distinct amino acids\, upon disrupting their supply\, and construct a logic based on individual amino acid costs as well as composite demand. We find that cells employ a conserved strategy guided by the law of demand\, to prioritize amino acid restorations upon transient limitation. In the second part of this seminar\, we uncover how cells differentially treat amino acids that are internally available\, vs those that accumulate externally. Quantitatively\, these internal and external amounts can differ by orders of magnitude\, and do not universally function as ‘public goods’. Distinct amino acids\, based on ease of availability as well as functional requirements\, can function either as contextually utilized public goods\, or carefully protected\, privatized resources that are banked for anticipated future requirements. I will end with speculation on how quantitative analyses of demand and supply can explain cellular resource allocation strategies in different environments. \n 
URL:https://be.iisc.ac.in/event/seminar-by-dr-sunil-laxman-on-economic-principles-of-metabolic-restoration-in-cells/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230807T160000
DTEND;TZID=UTC:20230807T170000
DTSTAMP:20260406T041611
CREATED:20230801T053041Z
LAST-MODIFIED:20230801T053041Z
UID:4394103-1691424000-1691427600@be.iisc.ac.in
SUMMARY:Seminar by Dr. Bala (Balasubramanian) Venkatakrishnan\, titled "Be On Top Of Your Cells: Flow Cytometry In The Cell Manufacturing Suite"
DESCRIPTION:Title:   Be On Top Of Your Cells: Flow Cytometry In The Cell Manufacturing Suite \n About the Speaker: \nBala Venkatakrishnan is a protein biochemist with a background in structural virology. He has spent about 10 years in academia followed by a little over 6 in the biotech industry (contract-research\, pharma and a product based companies). He has a passion for science communication and people management as he seek to answer life’s important scientific and healthcare questions. He is been with Beckman Coulter for close to 2 years as part of their flow cytometry reagent R&D team. Outside the lab\, he passionately drive Beckman’s DE+I and sustainability efforts. \nAbstract: The large variety in flow cytometry applications (ranging from cell manufacturing to diagnostics) requires customized solutions to meet specific user needs. At Beckman Coulter Life Sciences\, we emphasize customer-centric design with a focus on addressing key pain points. This talk will be a walkthrough on a range of Beckman products (hardware\, software and reagents) that address flow cytometry needs in cell manufacturing and clinical research spaces. \n  \n 
URL:https://be.iisc.ac.in/event/seminar-by-dr-bala-balasubramanian-venkatakrishnan-titled-be-on-top-of-your-cells-flow-cytometry-in-the-cell-manufacturing-suite/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230711T160000
DTEND;TZID=UTC:20230711T170000
DTSTAMP:20260406T041611
CREATED:20230608T221509Z
LAST-MODIFIED:20230608T221509Z
UID:4393778-1689091200-1689094800@be.iisc.ac.in
SUMMARY:Special Seminar by Prof. Yamuna Krishnan titled Intracellular electrophysiology
DESCRIPTION:The Centre for BioSystems Science and Engineering (BSSE) cordially invites you to attend a special seminar: \nSpeaker: Prof. Yamuna Krishnan \nDepartment of Chemistry\, \nInstitute for Biophysical Dynamics\, \nGrossman Institute for Neuroscience \nUniversity of Chicago \nTitle: Intracellular electrophysiology \nAbstract:  \nI have been interested in exploring how the ionic milieu within an organelle facilitates organelle function. To map these lumenal chemistries\, my lab developed a DNA-based\, fluorescent reporter technology to quantitatively map ions such as H+\, Cl- and Ca2+ within organelles (1). It can be applied to organelles of cells in culture\, in live organisms (2) and in human patient cells (3\,4). Our most recent reporter for absolute membrane potential ended a previous misconception by showing that many organelles do in fact\, have membrane potential (4). Today I will discuss two new reporters for organellar Na+ and K+ : the final pieces needed to build an electrochemical model for organelle membranes (5\,6). The only existing electrochemical model of a biological membrane is that of the cell membrane\, first developed by Hodgkin and Huxley in 1952 for neurons (7). To accomplish this for organelles we will need input from physicists\, cell biologists and electrophysiologists. \nReferences: \n\nKrishnan\, Y. et. al. “Quantitative imaging of biochemistry in situ and at the nanoscale.” ACS Cent. Sci.\, 2020\, 6\, 1938–1954.\nNarayanaswamy\, N. et. al. “A pH-correctable\, DNA-based fluorescent reporter for organellar Calcium.” Nature Methods\, 2019\, 16\, 95-102.\nLeung\, K.\, et. al. “A DNA Nanomachine chemically resolves lysosomes in live cells.” Nature Nanotechnology\, 2019\, 14\, 176-183.\nSaminathan\, A.\, et. al. “A DNA-based voltmeter for organelles.” Nature Nanotechnology\, 2021\, 16\, 96-103.\nAnees\, P. et al. “DNA nanodevices for measuring the organelle-specific activity of potassium channels.” 2023\, in revision.\nZou\, J. et al. “A DNA nanodevice maps sodium at single organelle resolution” 2023\, in revision.\nHodgkin A.L.\, Huxley A.F. “A quantitative description of membrane current and its application to conduction and excitation in nerve”. J. Physiol. 1952\, 117\, 500–44.
URL:https://be.iisc.ac.in/event/special-seminar-by-prof-yamuna-krishnan-titled-intracellular-electrophysiology/
LOCATION:Biological Sciences Auditorium
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230703T160000
DTEND;TZID=UTC:20230703T170000
DTSTAMP:20260406T041611
CREATED:20230604T223620Z
LAST-MODIFIED:20230605T030515Z
UID:4393774-1688400000-1688403600@be.iisc.ac.in
SUMMARY:Seminar by Dr. Sudin Bhattacharya titled Deep Generative Learning of Single Cell Gene Expression to predict Dose-Dependent Chemical Perturbations
DESCRIPTION:The Centre for BioSystems Science and Engineering (BSSE) cordially invites you to attend a departmental seminar. \nSpeaker: Dr. Sudin Bhattacharya \nDepartment of Biomedical Engineering\, Department of Pharmacology and Toxicology \nInstitute for Quantitative Health Science & Engineering \nMichigan State University \nAbstract:  \nSingle cell RNA-sequencing allows us to study cell-type specificity and heterogeneity of biological responses to chemical perturbations. However\, experimentally testing all relevant combinations of cell types\, chemicals\, and doses is a near-impossible task. A deep learning formalism called variational autoencoders (VAEs) has been shown to be effective in computationally predicting single-cell gene expression perturbations. We have developed single cell Variational Inference of Dose-Response (scVIDR)\, a VAE-based tool to predict the trajectory of cellular dose-response\, which achieves better dose-response predictions than existing models. We show that scVIDR can predict dose-dependent gene expression changes across cell types and interpret the latent space of the autoencoder model in terms of biological pathways.
URL:https://be.iisc.ac.in/event/seminar-by-dr-sudin-bhattacharya-titled-deep-generative-learning-of-single-cell-gene-expression-to-predict-dose-dependent-chemical-perturbations/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230626T143000
DTEND;TZID=UTC:20230626T170000
DTSTAMP:20260406T041611
CREATED:20230605T030307Z
LAST-MODIFIED:20230605T030307Z
UID:4393776-1687789800-1687798800@be.iisc.ac.in
SUMMARY:Seminar by Dr. Sooryanarayana Varambally titled Integrative Data Analysis Using UALCAN platform For Cancer Biomarker Discovery And Therapeutic Targeting
DESCRIPTION:Speaker: Dr. Sooryanarayana Varambally (University of Alabama at Birmingham) \nTitle: Integrative Data Analysis Using UALCAN platform For Cancer Biomarker Discovery And Therapeutic Targeting \nAbstract:  \nCancer is a complex disease that exhibits diverse morphological\, histological and molecular alterations during the initiation\, progression and metastasis. Cancer is a leading cause of death both in India and the western countries. Lung\, mouth\, esophagus\, stomach\, and nasopharynx cancers are the most common cancers in men and cancer of the breast and cervix\, uterine are the most common cancers in women in India. Lung\, breast\, prostate and colon cancer are common in the western countries. Advances in molecular profiling and sequencing technologies have resulted in generation of massive datasets for cancer genomics\, transcriptomics\, and proteomics. These have presented promising avenues for cancer research. Mining these data and utilizing them to their full potential requires the development of intuitive\, innovative and user-friendly web-portals. Not all cancers are the same\, and cancers of the same organ show molecular heterogeneity. Multiple “Omics” data and clinical parameters of patients help stratify cancers based on mutational status\, gene expression\, and survival patterns\, all of which may have relevant associations with stage\, race/ethnicity\, histologic subtypes\, genetic aberrations\, or other clinicopathologic parameters. In addition\, since the identification of DNA methylation and histone modification\, it has become clear that epigenetic modifiers that regulate gene expression play a crucial role in cancer progression. \nIn this era of precision medicine\, it is imperative that researchers and clinicians have the capability to identify candidate subclass-specific cancer biomarkers for the purposes of early diagnosis\, prediction of disease recurrence\, identification of molecular determinants for therapeutic targeting\, and re-purposing drugs to inhibit cancer growth. The Cancer Genome Atlas (TCGA) Research Network has profiled more than 10\,000 human tumors of 33 cancer types to discover genomic and epigenetic alterations. The Clinical Proteomic Tumor Analysis Consortium (CPTAC) provides data on protein expression in various cancers. Integrative informatics tools that harness these molecular modalities and allow intuitive analysis will allow researchers to uncover biological insights of specific tumors. The present talk focuses on our effort in the area of BIG cancer data dissemination through researcher-centric\, distinctive\, and continuously evolving web platform\, UALCAN (https://ualcan.path.uab.edu\, Yes! You All Can)\, for detailed data analyses and visualization. UALCAN\, released in 2017\, has been visited over 11\,85\,000 times by researchers from over 100 countries and has been cited about 4\,000 times\, creating a large global user base making cancer research a team effort and enabling numerous cancer target discoveries and biomarker development. Further\, here\, I will discuss about identification of viable targets\, validation. \nAbout the speaker:  \nDr. Sooryanarayana Varambally did his undergraduate studies at Poornaprajna College\, Udupi and M.Sc. in Biochemistry at Kasturba Medical College\, Mangalore. Varambally earned his Ph.D. in Biochemistry from the Indian Institute of Science in Bangalore\, India in 1997 under the mentorship of Late Prof. PR Adiga and Prof. Sandhya Visweswariah. He completed a research fellowship in immunology at INSERM unit at Hospital Broussias in Paris\, France with Dr. Srinivas Kaveri\, and a second research fellowship in cancer biology with Dr. Arul Chinnaiyan at the University of Michigan’s Department of Pathology. He later joined the Michigan Center for Translational Pathology in Ann Arbor as a faculty member. In 2015\, he joined the UAB Heersink School of Medicine Department of Pathology where he now serves as a professor and Director of Translational Oncologic Pathology Research as well as Co-Director of Cancer Biology Graduate Program and scientist at O’Neal Comprehensive Cancer Center and Informatics Institute. In an effort to enhance precision targeting in the fight against cancer\, Dr. Varambally initiated and led the development of a comprehensive proteogenomic cancer data analysis platform\, UALCAN (ualcan.path.uab.edu\, University of ALabama at Birmingham CANcer Portal\, Yes! You All Can). This user friendly public cancer data analysis tool allows cancer researchers and clinicians to examine cancer data and identify biomarkers and precision targets\, making cancer research a global team effort. UALCAN has received more than 1.2 million visits from over 100 countries and has been cited in more than 4\,000 research articles in the last 6 years. Dr. Varambally has co-authored more than 150 manuscripts. Many of his work has been published in journal like Science\, Nature\, Cancer Cell\, Cancer Discovery\, Nature Medicine\, NEJM\, JAMA\, Nature Biotechnology\, PNAS and Cancer Research\, among others. His work has been cited over 43\,000 times. Varambally was a member of the team that won the inaugural American Association for Cancer Research (AACR) Team Science Award in 2007 and received the Research Faculty Recognition Award from the University of Michigan in 2009. In 2021 he received the Outstanding Achievement Award from the Society of American Asian Scientists in Cancer Research. He was the recipient of the 2023 Dean’s Excellence Award in Research at the University of Alabama at Birmingham.
URL:https://be.iisc.ac.in/event/seminar-by-dr-sooryanarayana-varambally-titled-integrative-data-analysis-using-ualcan-platform-for-cancer-biomarker-discovery-and-therapeutic-targeting/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230427T160000
DTEND;TZID=UTC:20230427T170000
DTSTAMP:20260406T041611
CREATED:20230426T012703Z
LAST-MODIFIED:20230426T012703Z
UID:4393686-1682611200-1682614800@be.iisc.ac.in
SUMMARY:Special Lecture by Prof. Carla Rothlin titled: Cracking the cell death code
DESCRIPTION:Title: Cracking the cell death code \nAbstract: \nCell death is an invariant feature throughout our lifespan\, starting with extensive scheduled cell death during morphogenesis and continuing under homeostasis in adult tissues. Additionally\, cells become victims of accidental\, unscheduled death following injury and infection. Cell death in each of these occasions triggers specific and specialized responses in the living cells that surround them or are attracted to the dying/dead cells. These responses sculpt tissues during morphogenesis\, replenish lost cells in homeostasis to maintain tissue/system function\, and repair damaged tissues after injury. Wherein lies the information that sets in motion the cascade of effector responses to cell death? I will present a framework for thinking about cell death in terms of the specific effector responses that accompanies various cell death modalities. I will propose a three-fold “cell death code” consisting of information intrinsic to the dying/dead cell\, their surroundings and the identity of the responder. \nAbout the speaker: \nProf. Carla Rothlin is currently the Dorys McConnell Duberg Professor of Immunobiology and Professor of Pharmacology\, and Co-Leader\, Cancer Immunology\, Yale Cancer Center. She is the recipient of many prestigious awards including the senior research award from the Crohn’s and Colitis foundation of America\, the early excellence award from the American Asthma Foundation and the HHMI faculty scholar from the Howards Hughes Medical Institute. \n 
URL:https://be.iisc.ac.in/event/special-lecture-by-prof-carla-rothlin-titled-cracking-the-cell-death-code/
LOCATION:Biological Sciences Auditorium
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230324T140000
DTEND;TZID=UTC:20230324T150000
DTSTAMP:20260406T041611
CREATED:20230320T062300Z
LAST-MODIFIED:20230320T062300Z
UID:4393635-1679666400-1679670000@be.iisc.ac.in
SUMMARY:Special Lecture by Dr. Gaurav Das on "The food fly: neural circuits of feeding and emesis in Drosophila"
DESCRIPTION:Title: The food fly: neural circuits of feeding and emesis in Drosophila \nAbstract: \nOur group is broadly interested in understanding how the brain communicates with the gut and other organ systems to regulate food/nutrient intake. Food intake is mainly influenced by innate sensory inputs and also by memories of past feeding experiences. We have developed and improved handy assays for quantifying feeding and memory in flies. Armed with these assay we are trying to understand the neural circuitry that control specific feeding phenotypes. \nThe ability to avoid\, and reject toxic foods that cause malaise are of the greatest importance to animals. Incredibly\, fruit flies show emesis or vomiting upon toxin ingestion. We show that the requirement of the neurotransmitters serotonin and dopamine in regulating emesis is conserved between flies and mammals. We also have evidencethat suggests that flies form a robust long-lasting aversive memory\, reinforced by the internal sickness caused by toxin ingestion. We are now elucidating the circuitry that underlies innate and naive emesis in flies. \nAbout the speaker: \nGaurav did his BSc in Chemistry with Microbiology from Ahmednagar College\, Ahmednagar\, Maharashtra\, and then an MSc in Biotechnology from Jawaharlal Nehru University\, New Delhi. For his Ph.D.\, he studied mouse retina development\, in the lab of Dr. Edward Levine\, at The University of Utah\, Salt Lake City\, Utah\, USA. He then moved to the lab of Dr. Scott Waddell\, at the UMASS Chan Medical School\,  to understand how aversive food memories are formed in the Drosophila brain and guide behavior. He moved with the lab to the University of Oxford\, UK to continue his postdoctoral research. In December 2017\, he joined NCCS to establish the Brain and Feeding Behavior Laboratory.
URL:https://be.iisc.ac.in/event/special-lecture-by-dr-gaurav-das-on-the-food-fly-neural-circuits-of-feeding-and-emesis-in-drosophila/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230320T160000
DTEND;TZID=UTC:20230320T170000
DTSTAMP:20260406T041611
CREATED:20230313T061123Z
LAST-MODIFIED:20230313T061123Z
UID:4393624-1679328000-1679331600@be.iisc.ac.in
SUMMARY:Seminar by Prof. Marty Pagel on "Molecular Imaging of the Tumor Microenvironment"
DESCRIPTION:Speaker: Prof. Marty Pagel (The University of Texas MD Anderson Cancer Center\, Houston\, Teax ) \nTitle: Molecular Imaging of the Tumor Microenvironment \nAbstract: \nTumor acidosis\, hypoxia and vascular perfusion are well-known characteristics of the tumor microenvironment. We have developed MRI\, PET/MRI\, multispectral optoacoustic tomography (MSOT) and electron paramagnetic resonance imaging (EPRI) to measure extracellular pH\, oxygenation and pharmacokinetics transport rates in solid tumors. We apply these molecular imaging methods to preclinical tumor models\, and we have translated some of our methods to evaluate patients who have cancer. We are especially focused on employing molecular imaging to predict treatment effect before starting therapy\, and to evaluate the early response to treatment\, during evaluations of chemotherapy\, radiotherapy and immunotherapy. This presentation will discuss a variety of molecular imaging methods and research applications\, and also discuss a value proposition for molecular imaging. \nAbout the speaker: \nDr. Marty Pagel is a Professor in the Departments of Cancer Systems Imaging and Imaging Physics at the University of Texas MD Anderson Cancer Center. His research in academia and industry has evolved from physical chemistry to molecular imaging. His current research employs a variety of imaging modalities to interrogate biomarkers of the tumor microenvironment. He has developed these methods for pre-clinical and clinical imaging\, especially to evaluate cancer therapies. Dr. Pagel has held many leadership positions in molecular imaging\, including roles in scientific societies of WMIS\, SNMMI and the ISMRM\, and serves as the Associate Editor of Radiology. When away from the lab and imaging facilities\, Marty enjoys coffee\, jazz music\, Green Bay Packers football games\, and a variety of wilderness adventures. \n 
URL:https://be.iisc.ac.in/event/seminar-by-prof-marty-pagel-on-molecular-imaging-of-the-tumor-microenvironment/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230315T080000
DTEND;TZID=UTC:20230315T170000
DTSTAMP:20260406T041611
CREATED:20230315T055811Z
LAST-MODIFIED:20230315T055844Z
UID:4393632-1678867200-1678899600@be.iisc.ac.in
SUMMARY:MTech program in Bioengineering
DESCRIPTION:Unlock your potential with our MTech program in Bioengineering. Apply now to gain expertise\, industry connections\, and become a leader in this transformative field. Submission deadline : 23rd March 2023 Eligibility criteria and how to apply: https://iisc.ac.in/admissions/
URL:https://be.iisc.ac.in/event/mtech-program-in-bioengineering/
CATEGORIES:Announcement
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230313T160000
DTEND;TZID=UTC:20230313T170000
DTSTAMP:20260406T041611
CREATED:20230307T231421Z
LAST-MODIFIED:20230307T231421Z
UID:4393600-1678723200-1678726800@be.iisc.ac.in
SUMMARY:Seminar by Dr. Somenath Bakshi on "Connecting the dynamics of microbial systems across scales"
DESCRIPTION:Title: Connecting the dynamics of microbial systems across scales \nAbstract:  \nBiological reactions often involve low-copy molecular reactants\, leading to stochastic outcomes. As a result\, there is substantial heterogeneity among cells\, even when they experience the same external conditions. Recent theoretical and experimental investigations have demonstrated that for microbial systems such heterogeneity is of important consequence to the population fitness and therefore also important for their evolution. We are establishing an experimental framework to connect the single-cell level picture of microbes to the short-term and long-term behaviours of their populations. We are using this approach to analyse the extent and role of cellular heterogeneity in determining the population dynamics of microbial systems in the context of – 1. Emergence of antibiotic persistence 2. Fitness costs of plasmids carrying antibiotic resistance genes and 3. The arms race between bacteria and bacteriophages.  In this talk I will describe the background and motivation for this approach\, the key challenges\, the necessary technical advancements\, and illustrate its potential with selected key findings \nAbout the Speaker: \nSomenath Bakshi is an Assistant Professor in the Department of Engineering at the University of Cambridge. He did his PhD in University of Wisconsin Madison under Professor James Weisshaar – developing super-resolution imaging technologies to study central cellular processes in microbes. After finishing his PhD\, he moved to Harvard University for his postdoc with Professor Johan Paulsson in the Department of Systems Biology. During his postdoc Somenath developed high-throughput timelapse imaging technologies to study stress-response in bacteria. In 2019\, he moved to Cambridge\, and established the Laboratory of Systems and Synthetic Microbiology. His work focuses on the analysis of the genetic and metabolic factors underlying the emergence of antibiotic resistance\, and engineering diagnostic and therapeutic strategies to combat the spread of antibiotic resistance. He is also the head of the recently established Smart Microscopy Laboratory\, which is a cross-school platform for bringing together engineers\, computer scientists\, and biologists to develop targeted imaging solutions for specific biological problems. \nPlatform: MS Teams (Online) \nlink for the Seminar: https://tinyurl.com/3vcsm2jt
URL:https://be.iisc.ac.in/event/seminar-by-dr-somenath-bakshi-on-connecting-the-dynamics-of-microbial-systems-across-scales/
LOCATION:Online
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230313T113000
DTEND;TZID=UTC:20230313T123000
DTSTAMP:20260406T041611
CREATED:20230219T223520Z
LAST-MODIFIED:20230220T014642Z
UID:4393532-1678707000-1678710600@be.iisc.ac.in
SUMMARY:BSSE Lecture by Prof. Joachim Spatz on "Matter to Life: Bottom-Up Assembly of Synthetic Cells".
DESCRIPTION:Register here:  https://forms.gle/kf1cYCUB6wcydwe8A
URL:https://be.iisc.ac.in/event/bsse-lecture-by-prof-joachim-spatz-on-matter-to-life-bottom-up-assembly-of-synthetic-cells/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230307T160000
DTEND;TZID=UTC:20230307T170000
DTSTAMP:20260406T041611
CREATED:20230227T234540Z
LAST-MODIFIED:20230227T234540Z
UID:4393598-1678204800-1678208400@be.iisc.ac.in
SUMMARY:Seminar by Prof. Anup Singh on "Molecular Imaging using CEST MRI: Acquisition\, Analysis and Applications"
DESCRIPTION:Title: Molecular Imaging using CEST MRI: Acquisition\, Analysis and Applications \nAbstract:  \nMRI is routinely being used to obtain different types of images that are sensitive to structural\, functional\, and physiological information. The use of MRI in disease diagnosis\, treatment planning\, and treatment monitoring is rapidly growing. Chemical-exchange-saturation-transfer (CEST) is an advanced MRI techniques which provides high resolution molecular information. CEST MRI of multiple in vivo molecules has been demonstrated and research studies are being carried out to evaluate their clinical potential. In this talk\, an overview of the molecular imaging using CEST MRI shall be presented\, including data acquisition approaches\, quantitative analysis and some applications. \n About the Speaker: \nDr. Anup Singh is currently an Associate Professor at the Centre for Biomedical Engineering (CBME)\, IIT-Delhi and is associated as a faculty with the Department of Biomedical Engineering\, All India Institute of Medical Sciences\, AIIMS\, New Delhi. Dr. Singh received a PhD degree from the Department of Mathematics and Statistics\, Indian Institute of Technology Kanpur (IIT-Kanpur) in 2008. Dr. Singh has worked as a Postdoctoral Researcher (Aug 2008 – March 2013) in the Center for Magnetic Resonance and Optical Imaging (CMROI)\, Department of Radiology at University of Pennsylvania(UPENN) and then as a Research Associate (April 2013 – March 2014) in the same Center. His group is pursuing multiple research projects on the development of the methodology of quantitative multi-parametric MRI and evaluating its potential applications to cancer (brain tumor\, breast cancer and prostate cancer) diagnosis and treatment monitoring.
URL:https://be.iisc.ac.in/event/seminar-by-prof-anup-singh-on-molecular-imaging-using-cest-mri-acquisition-analysis-and-applications/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230227T160000
DTEND;TZID=UTC:20230227T170000
DTSTAMP:20260406T041611
CREATED:20230220T221755Z
LAST-MODIFIED:20230220T221946Z
UID:4393589-1677513600-1677517200@be.iisc.ac.in
SUMMARY:Seminar by Dr. Rati Sharma on "Systems Biology In Action: A dive into signaling pathways and behavioral dynamics"
DESCRIPTION:Speaker: Dr. Rati Sharma \nTitle: Systems Biology In Action: A dive into signaling pathways and behavioral dynamics \nAbstract: \n“Systems Biology” refers to the study of biological systems through modeling\, experiments and computational tools. In particular\, the workings and implications of genetic networks\, behavior and signal-response can be studied through the tools and techniques adapted from the field of systems biology. This field\, therefore\, has an important role to play in the understanding of biological entities\, be it at the level of the cell\, tissue or organism. In this talk\, I will discuss our work in the area of systems biology along four major themes\, namely\, (i) theoretical and computational modeling of signaling pathways using concepts from chemical kinetics and non-equilibrium statistical mechanics; (ii) signal response studies in the nematode (roundworm) C. elegans; (iii) development of microfluidics devices and (iv) development of machine learning tools for the study of biological systems. \nIn the first part of my talk\, I will discuss one example of a cellular pathway\, viz. the immune response pathway\, where noise or fluctuations plays an important role. Through the analysis of this system and upon comparing the theoretically predicted average virus levels to those of COVID-19 patients\, we hypothesize that the long lived viral dynamics are due to the long range correlations in the temporal fluctuations of the virion [1\, 2]. Next\, I will discuss the sensation and behavioral aspects of the model organism C. elegans in response to a heat shock and chemical stimuli [3]. Third\, I will talk about the development of microfluidics devices that can aid in performing controlled experiments with these model organisms [4]. And finally\, given the need for automation in labor intensive behavioral studies in C. elegans\, I will also discuss our efforts in this direction and talk about the recently developed Deep-Worm-Tracker from our lab [5]. I will\, therefore\, provide an overview of the kind of important biological questions that can be addressed through a combination of modeling\, computational and experimental studies. \nReferences: \n\nPersistent correlation in cellular noise determines longevity of viral infections. Abhilasha Batra\, Shoubhik Banerjee and Rati Sharma*\, J. Phys. Chem. Lett. 13\, 7252 (2022). https://doi.org/10.1021/acs.jpclett.2c01875\nA near analytic solution of a stochastic immune response model considering variability in virus and T-cell dynamics. Abhilasha Batra and Rati Sharma*\, J. Chem. Phys. 154\, 195104 (2021). https://doi.org/10.1063/5.0047442\nLessons learned from two decades of modeling the heat shock response. Ayush Ranawade\, Rati Sharma and Erel Levine\, Biomolecules 12\, 1645 (2022).https://doi.org/10.3390/biom12111645\nMicrofluidics based bioimaging with cost-efficient fabrication of multi-level micron sized trenches. A Anand\, Abhilasha Batra\, Santanu Talukder and Rati Sharma*\, Submitted.\nDeep-Worm-Tracker: Deep Learning Methods for Accurate Detection and Tracking for Behavioral Studies in C. elegans.Shoubhik Chandan Banerjee\, Khursheed Ahmad Khan and Rati Sharma*\, Under review. (bioRxiv preprint: https://doi.org/10.1101/2022.08.18.504475)\n\nAbout the Speaker:  \nDr. Rati Sharma is an Assistant Professor in the Dept. of Chemistry at Indian Institute of Science Education and Research (IISER) Bhopal. She graduated in Chemistry from Stella Maris College\, Madras University in 2007. Following this\, she joined the Integrated PhD program of the Division of Chemical Sciences at Indian Institute of Science\, Bangalore\, where she completed her MS and PhD in 2013 under the guidance of Prof. Binny J. Cherayil. Her PhD thesis primarily focussed on questions in theoretical biophysics and polymer physics. She then pursued postdoctoral research at the Dept. of Biophysics\, Johns Hopkins University\, USA from 2013-2016 and at the Dept. of Physics\, Harvard University\, USA from 2016 to 2018. Her postdoctoral research training encompassed a variety of topics in systems biology. She moved back to India in 2019 where she has steadily established her group. She has received research grants from both DST-SERB and DBT since she joined IISER Bhopal. Her current research interests focus on computational and experimental biophysics\, ranging from topics such as stress response dynamics in C. elegans and modeling of signaling pathways to machine learning applications in biological research\, to name a few. \n 
URL:https://be.iisc.ac.in/event/seminar-by-dr-rati-sharma-on-systems-biology-in-action-a-dive-into-signaling-pathways-and-behavioral-dynamics/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230223T143000
DTEND;TZID=UTC:20230223T153000
DTSTAMP:20260406T041611
CREATED:20230219T223953Z
LAST-MODIFIED:20230219T223953Z
UID:4393535-1677162600-1677166200@be.iisc.ac.in
SUMMARY:Seminar by Dr. Lorena Escudero Sanchez on "AI applications in radiological image analysis for cancer research
DESCRIPTION:Speaker: Dr. Lorena Escudero Sanchez\, University of Cambridge \nTitle: AI applications in radiological image analysis for cancer research \nAbstract: \nImaging is one of the main pillars of clinical protocols for cancer care that provides essential non-invasive biomarkers for detection\, diagnosis and response assessment. The development of Artificial Intelligence (AI) tools have proven potential to transform the analysis of radiological images\, by significantly reducing processing time\, by increasing the reproducibility of measurements and by improving the sensitivity of tumour detection compared to the standard visual interpretation\, leading to cancer early detection. In this talk I will highlight some of the work done in our Radiogenomics and Quantitative Image Analysis group\, covering methods for automated tumour segmentation\, in particular in ovarian cancer\, a highly complex\, heterogeneous and metastatic cancer. I will also present studies on Radiomic features\, quantitative measurements extracted directly from images such as CT or MR\, and examples of Machine Learning models based on these variables to predict response to chemotherapy treatment. Finally\, we will briefly see some examples of clinical applications of such image analysis methods. \nAbout the Speaker: \nDr Lorena Escudero Sánchez is a particle physicist\, with a PhD in neutrino physics\, who has worked in large international collaborations for the neutrino oscillation experiments T2K (Japan)\, MicroBooNE and DUNE (US). She now works on AI applications to radiological image analysis for cancer research\, at the Department of Radiology of the University of Cambridge and CRUK Cambridge Centre. She is also part of the Repository team of the National Cancer Imaging Translational Award (NCITA) consortium across different UK institutions. As a Senior Research Associate at the Department of Radiology in Cambridge\, she leads the Radiogenomics and Quantitative Image Analysis group. She is also a Turing Fellow of The Alan Turing Institute\, the UK national centre for AI and Data Science\, a Borysiewicz Interdisciplinary Fellow of the University of Cambridge\, and a Rokos Postdoctoral Research Associate at Queens’ College Cambridge.
URL:https://be.iisc.ac.in/event/seminar-by-dr-lorena-escudero-sanchez-on-ai-applications-in-radiological-image-analysis-for-cancer-research/
LOCATION:M Tech Classroom\, BSSE Annex
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230222T110000
DTEND;TZID=UTC:20230222T120000
DTSTAMP:20260406T041611
CREATED:20230215T010952Z
LAST-MODIFIED:20230215T010952Z
UID:4393512-1677063600-1677067200@be.iisc.ac.in
SUMMARY:Seminar by Dr. Mirunalini Thirugnanasambandam on Image-based biomechanics
DESCRIPTION:Title of Talk: Image-based biomechanics in the era of personalized medicine \nSpeaker Name: Mirunalini Thirugnanasambandam \nSpeaker Affiliation: Eindhoven University of Technology\, Netherlands \nAbstract of Talk \nIn the age of digital twins\, when clinical management is moving towards a more personalized approach\, it is often desired to evaluate patient-specific geometry and mechanical behavior. While ex-vivo tests can estimate individualized tissue properties\, they are usually not a viable solution due to either tissue unavailability\, or due to the tests being destructive. In my talk\, I will shed light on novel methods for evaluation of patient-specific vascular biomechanics using an innovative combination of in-vivo imaging modalities (ultrasound and MRI)\, and image-based biomechanical modeling. In particular\, aortic wall motion takes the central stage since it inherently contains information on local mechanical behavior of the aorta. I will also demonstrate the value of building multi-scale circulation loops representing (patho-) physiological conditions – illustrating that they not only serve to validate new techniques\, but also possess the ability to shed light on disease mechanisms which may otherwise go unnoticed. Finally\, a futuristic outlook on ways to improve the translational potential of these sophisticated models will be discussed. \nBrief Bio of Speaker \nDr. Mirunalini Thirugnanasambandam obtained her undergraduate degree in Mechanical Engineering from College of Engineering Guindy\, Anna University\, Chennai. She did her Masters’ degree in Mechanical Engineering at McGill University\, Canada\, where she worked on signal processing techniques in non-linear systems. Her curiosity about non-linear systems in nature led her to pursue a PhD in cardiovascular biomechanics at University of Texas at San Antonio\, USA\, with Prof. Ender Finol\, while doing a research exchange at Ecole des Mines\, St Etienne\, France\, with Prof. Stephane Avril. She began her postdoctoral research at University of Bern\, Switzerland\, where she worked with Prof Dominik Obrist\, and later began her current postdoctoral position at Eindhoven University of Technology\, Netherlands with Dr. Richard Lopata. Her research focuses on both experimental and computational sides of cardiovascular mechanics\, with special emphasis on abdominal aortic aneurysms and coronary microvascular obstruction. She has developed and validated computationally inexpensive novel methods to estimate vascular biomechanics from medical images.
URL:https://be.iisc.ac.in/event/seminar-by-dr-mirunalini-thirugnanasambandam-on-image-based-biomechanics/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230221T110000
DTEND;TZID=UTC:20230221T120000
DTSTAMP:20260406T041611
CREATED:20230220T015219Z
LAST-MODIFIED:20230220T015219Z
UID:4393550-1676977200-1676980800@be.iisc.ac.in
SUMMARY:Special talk by Mr. Sarath Kolli on "Automation of therapeutics design in the era of Artificial Intelligence"
DESCRIPTION:Speaker: Mr. Sarath Kolli\, CEO of Boltzmann Labs \nTitle: Automation of therapeutics design in the era of Artificial Intelligence \nAbstract:  \nAutomation of the therapeutic design process through the integration of AI has drastically improved the efficiency and effectiveness of pharmaceutical research. With the power to assess large amounts of data within a short timeframe\, AI algorithms can detect patterns\, recognize target proteins and design potential treatments – all of which can be achieved much faster than human scientists can manage. This has resulted in the creation of groundbreaking drugs which have revolutionized the way that diseases are tackled. The speed of AI algorithms is one of the major benefits that has been gained from automating therapeutic design. \nAI algorithms are capable of rapidly processing massive data sets and accurately pinpointing target proteins and designing potential medications. This allows scientists to save time and money. Furthermore\, these AI tools can be used to refine the production process of these pharmaceuticals\, making them more efficient. Additionally\, AI algorithms can assess vast amounts of data and make predictive conclusions with a higher degree of accuracy compared to manual methods. This has significantly raised the success rate of clinical trials\, which has been a long-standing difficulty in the pharmaceutical sector. \nThe emergence of AI in the pharmaceutical industry has meant a shift in the way treatments are discovered. By using AI algorithms to analyze data from various sources\, such as genomics\, proteomics\, and pharmacology\, new targets for drugs have been identified\, which has resulted in new treatments for previously incurable diseases. As AI technology advances\, even more\, breakthroughs can be expected in the future\, providing much-needed hope to those in need.
URL:https://be.iisc.ac.in/event/special-talk-by-mr-sarath-kolli-on-automation-of-therapeutics-design-in-the-era-of-artificial-intelligence/
LOCATION:CES Classroom\, CES Classroom\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230220T160000
DTEND;TZID=UTC:20230220T170000
DTSTAMP:20260406T041611
CREATED:20230219T224107Z
LAST-MODIFIED:20230219T224107Z
UID:4393537-1676908800-1676912400@be.iisc.ac.in
SUMMARY:Seminar by Prof. Herbert Levine on "Cell – ECM interactions and their relevance for cancer progression
DESCRIPTION:Speaker: Prof. Herbert Levine (Satish Dhawan Visiting Chair Professor\, IISc) \nTitle: Cell – ECM interactions and their relevance for cancer progression \nAbstract: \nDuring metastasis\, tumor cells must traverse fibrous extracellular matrix (ECM) en route to the circulation. Conversely\, immune cells must traverse the same medium en route to attacking a tumor. Thus\, the study of the reciprocal feedbacks between cell motility and ECM is a crucial aspect of understanding cancer progression and its possible interdiction. This understanding is made more difficult by the highly nonlinear mechanics of ECM and by the multiple modes of cell motion in complex media. This talk will focus on recent progress as well as open issues in this rapidly advancing research topic. \nAbout the Speaker:  \nHerbert Levine is a University Distinguished Professor of Physics and Bioengineering at Northeastern University. He is also the co-director of a National Science Foundation Physics Frontier Center devoted to theoretical biological physics. He earned his Ph.D. and an M.A. in physics from Princeton University and a B.S. in physics from Massachusetts Institute of Technology. For several decades\, he has been an acknowledged leader in applying methods from physical science to diverse living systems – self-organization of bacterial colonies\, directed motion of eukaryotic cells\, biophysical modeling of cancer progression and metastasis\, and tumor-immune interactions. He spent 25 years on the faculty of UCSD before moving to Rice University in 2012. He has served as an Associate Editor of Biophysical Journal and as the Editor-in-Chief of Physical Biology. He is a Fellow of American Physical Society (APS)\, and an elected member of the American Academy of Arts and Sciences (AAAS) & National Academy of Sciences (NAS).
URL:https://be.iisc.ac.in/event/seminar-by-prof-herbert-levine-on-cell-ecm-interactions-and-their-relevance-for-cancer-progression/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230215T120000
DTEND;TZID=UTC:20230215T130000
DTSTAMP:20260406T041611
CREATED:20230214T000318Z
LAST-MODIFIED:20230214T000318Z
UID:4393510-1676462400-1676466000@be.iisc.ac.in
SUMMARY:LUMICKS (Amsterdam\, The Netherlands) \, "Tractor beams and single molecules: How to visualize and manipulate single biomolecules in real-time
DESCRIPTION:Title: Tractor beams and single molecules: How to visualize and manipulate single biomolecules in real-time \nAbstract: \nImagine you could directly see the location and dynamics of individual proteins binding to a piece of single DNA. What if you could assemble your biological complex step by step and see it in action in real-time? What if you could manipulate the structure of your biomolecule and quickly change buffer conditions to test your experimental hypotheses? By using “molecular tractor beams”\, the C-trap makes that a reality. \nEssential biological processes performed by proteins interacting with DNA or cytoskeletal protofilaments are key to cell metabolism and life. In order to understand the molecular basis of life\, as well as the pathological conditions that develop when processes go wrong\, it is critical to get detailed insights into these processes at the molecular level. Not only at the highest resolution\, but also in real time. \nDuring this seminar\, we will take you through an exciting journey of different research topics in which dynamic single molecule studies revealed remarkable insights. In each study\, the C-Trap system was used; our easy-to-use platform that combines optical tweezers with fluorescence microscopy. We will explain how the ability to control\, visualize and manipulate single molecules in real time\, changes the way we answer tough scientific questions in the field of DNA processing\, single-protein dynamics\, liquid-liquid phase separation (LLPS) and beyond.
URL:https://be.iisc.ac.in/event/lumicks-amsterdam-the-netherlands-tractor-beams-and-single-molecules-how-to-visualize-and-manipulate-single-biomolecules-in-real-time/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230214T100000
DTEND;TZID=UTC:20230214T110000
DTSTAMP:20260406T041611
CREATED:20230213T000405Z
LAST-MODIFIED:20230213T000405Z
UID:4393506-1676368800-1676372400@be.iisc.ac.in
SUMMARY:Guest Lecture by Areejit Samal on Elucidating and leveraging the design principles towards realistic Boolean models of gene regulatory networks
DESCRIPTION:Title: Elucidating and leveraging the design principles towards realistic Boolean models of gene regulatory networks \nSpeaker: Areejit Samal (The Institute of Mathematical Sciences (IMSc)\, Chennai) \nVenue: MRDG Conference Room \nAbstract: \nBoolean networks is a widely-used mathematical framework to model gene regulatory networks. Such Boolean models consist of a set of nodes\, directed edges between the nodes\, and Boolean functions representing the regulatory logic at each node in the network. \nIn the first part of my talk\, I will discuss several biologically-meaningful types of BFs\, and present our systematic study of their preponderance in a compilation of 2687 regulatory rules extracted from published Boolean models of diverse biological systems [1]. A surprising observation in the empirical dataset is that most Boolean functions have an odd ‘bias’. Thereafter\, we are able to explain this observation along with the enrichment of read-once functions (RoFs) and its nested canalyzing functions (NCFs) subset\, in terms of two complexity measures: Boolean complexity and average sensitivity. In particular\, we show that the RoFs minimize Boolean complexity and the NCFs minimize the average sensitivity in addition to minimizing the Boolean complexity\, and this highlights the importance of minimum complexity in the regulatory logic of biological networks [1]. \nIn the second part of my talk\, I will present our systematic framework leveraging biologically-meaningful regulatory logic and relative stability of cell fates or attractors for model selection of Boolean developmental gene regulatory networks [2]. In particular\, I show the usefulness of mean first passage time (MFPT) as a measure to capture cell state transitions within the Boolean framework and construction of cellular lineage trees. Thereafter\, I will show an application of these tools towards in-depth analysis and subsequent improvement of existing Boolean models of Arabidopsis root development [2]. \n\nA. Subbaroyan\, O.C. Martin & A. Samal\, Minimum complexity drives regulatory logic in Boolean models of living systems\, PNAS Nexus\, 1(1): pgac017 (2022).\nA. Subbaroyan\, P. Sil\, O.C. Martin & A. Samal\, Leveraging Developmental Landscapes for Model Selection in Boolean Gene Regulatory Networks\, bioRxiv 2023.01.08.523151.\n\nAbout the Speaker: \nAreejit Samal is a faculty member in the computational biology group of The Institute of Mathematical Sciences\, Chennai since April 2014. He obtained his Bachelors\, Masters and PhD from University of Delhi. Subsequently\, he did Postdoctoral research at the Max Planck Institute for Mathematics in the Sciences Leipzig\, CNRS/LPTMS Orsay\, Institute for Systems Biology Seattle\, and ICTP Trieste. He has been a recipient of FEBS Short term Research Fellowship\, Ramanujan Fellowship\, Simons Associateship of ICTP and a Max Planck Partner Group. His research interests span the broad area of complex systems / networks\, in particular\, its applications to biological systems.
URL:https://be.iisc.ac.in/event/guest-lecture-by-areejit-samal-on-elucidating-and-leveraging-the-design-principles-towards-realistic-boolean-models-of-gene-regulatory-networks/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230213T160000
DTEND;TZID=UTC:20230213T170000
DTSTAMP:20260406T041611
CREATED:20230212T233801Z
LAST-MODIFIED:20230212T233801Z
UID:4393504-1676304000-1676307600@be.iisc.ac.in
SUMMARY:Seminar by Prof. Herbert Levine on The Tumor-Immune Interaction: Pieces of a Multiscale Story
DESCRIPTION:Title: The Tumor-Immune Interaction: Pieces of a Multiscale Story \nAbstract: \nOne of the most important advances in cancer research over recent years has been the renewed excitement regarding using the immune system to attack malignant cells. Understanding and managing the battle between adaptive immunity and the tumor is a complex multiscale problem\, involving the molecular biophysics of immune recognition\, the cellular processes of direct checkpoint-dependent evasion\, and the ecological dynamics of the microenvironmental milieu. This talk will highlight some of our recent attempts to analyze pieces of this problem and to begin to assemble these pieces into a coherent picture. \nAbout the speaker: \nHerbert Levine is a University Distinguished Professor of Physics and Bioengineering at Northeastern University. He is also the co-director of a National Science Foundation Physics Frontier Center devoted to theoretical biological physics. He earned his Ph.D. and an M.A. in physics from Princeton University and a B.S. in physics from Massachusetts Institute of Technology. For several decades\, he has been an acknowledged leader in applying methods from physical science to diverse living systems – self-organization of bacterial colonies\, directed motion of eukaryotic cells\, biophysical modeling of cancer progression and metastasis\, and tumor-immune interactions. He spent 25 years on the faculty of UCSD before moving to Rice University in 2012. He has served as an Associate Editor of Biophysical Journal and as the Editor-in-Chief of Physical Biology. He is a Fellow of American Physical Society (APS)\, and an elected member of the American Academy of Arts and Sciences (AAAS) & National Academy of Sciences (NAS).
URL:https://be.iisc.ac.in/event/seminar-by-prof-herbert-levine-on-the-tumor-immune-interaction-pieces-of-a-multiscale-story/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20230102T160000
DTEND;TZID=UTC:20230102T170000
DTSTAMP:20260406T041611
CREATED:20221229T013402Z
LAST-MODIFIED:20221229T013402Z
UID:4392999-1672675200-1672678800@be.iisc.ac.in
SUMMARY:Seminar by Dr. Tarini Shankar Ghosh on The gut microbiome and biological aging
DESCRIPTION:Speaker: Dr. Tarini Shankar Ghosh (Indraprastha Institute of Information Technology\, IIIT-Delhi) \nTitle: The gut microbiome and biological aging \nAbstract: \n“The gut harbours one of the largest microbial communities found in human body\, with more than 1.3 trillion microbial cells encoding a functional capacity estimated to be more than 150 times the coding capacity of our own. Alterations in the gut microbiome have been associated with many aspects of human physiology\, some of the medically and economically significant multifactorial non-communicable diseases as well as with the treatment responses of individuals to different therapeutic interventions. \nAge is one such aspect of host physiology having one of the strongest associations with the composition of the gut microbiome. Aging is associated with a progressive decline in multiple bodily functions and an onset of low-grade inflammation (referred to as ‘Inflammaging’). But even in healthy people\, the gut microbiome alters with age. Are age-associated gut microbiome alterations a cause or a mere consequence of a declining state of human health? Or do these alterations indicate a transition to an even more vicious cycle of deterioration in host physiology? Can these alterations in a host be ‘reset’ using microbiome-targeted therapeutics to delay the transition to an unhealthy aging trajectory? In this talk\, I will some of the recent genomic and metagenomic studies (including some of my previous works) that have attempted to answer the above questions. I will also briefly describe specific examples\, where in we observed the gut microbiome to be a key transducer of the beneficial signals of diet on health of older people. Finally\, my talk will provide implications for future\, including the prospects of devising microbiome-targeted diagnostic/therapeutic strategies specifically customized for societies like India for improving human health.” \nAbout the Speaker: \nTarini Shankar Ghosh is an Assistant Professor of Computational Biology at the Indraprastha Institute of Information Technology Delhi (IIIT-Delhi). He received his B.Tech from Indian Institute of Technology (IIT) Kharagpur\, his M.Tech from IIT Kanpur and his Ph.D from the University of Hyderabad. After completing his PhD\, he first moved to the Genome Institute of Singapore (as a post-doctoral researcher) and then to his current institute APC Microbiome Ireland at Cork. His core research focus is to understand gut microbial ecology using an in-silico approach. He uses a combination of metagenome informatics\, machine learning and statistical approaches to identify the generic microbial markers of health\, their variation across various population-strata\, their alterations in different disease conditions and finally the formulation of personalized diet/symbiotic-based microbiome restoration strategies for improving human health. He has published more than 50 research papers in notable journals including Nature Medicine\, Nature Reviews Gastroenterology and Hepatology\, Nature Aging\, Nature Ecology and Evolution\, Gut (British Medical Journals)\, Gastroenterology (American Gastroenterological Association) and Cell hosts and microbes. He has 8 US/EU based patents pertaining to metagenomic data analysis algorithms and design of microbial consortia targeted to ameliorate frailty and colorectal cancer. Dr. Ghosh was also selected for the Pathway Investigator Award by the Science Foundation of Ireland and the Irish Research Council for the year 2022. He has also been a recipient of the Yakult Young Investigator Award in the year 2014 and the Torrent Pharmaceuticals – ISHR Young Investigator Award in the year 2017.
URL:https://be.iisc.ac.in/event/seminar-by-dr-tarini-shankar-ghosh-on-the-gut-microbiome-and-biological-aging/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20221229T080000
DTEND;TZID=UTC:20221229T170000
DTSTAMP:20260406T041611
CREATED:20221229T041455Z
LAST-MODIFIED:20221229T042037Z
UID:4393016-1672300800-1672333200@be.iisc.ac.in
SUMMARY:9th Annual Symposium\, BSSE 2023 (19th-21st Jan 2023)
DESCRIPTION:
URL:https://be.iisc.ac.in/event/9th-annual-symposium-bsse-2023-19th-21st-jan-2023/
CATEGORIES:Announcement,BSSE Symposium
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END:VCALENDAR