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X-WR-CALDESC:Events for Department of Bioengineering
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DTSTART:20220101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20221205T160000
DTEND;TZID=UTC:20221205T170000
DTSTAMP:20260406T080551
CREATED:20221128T234235Z
LAST-MODIFIED:20221128T234404Z
UID:4392744-1670256000-1670259600@be.iisc.ac.in
SUMMARY:Seminar by Dr. Parag Katira on Mechanics of Cancer
DESCRIPTION:Title: Mechanics of Cancer \nAbstract:  \nCancer is a disease rooted in genetic mutations and epigenetic regulation of cell biology. There is extensive heterogeneity in the biological drivers of this disease across cancer types\, across patients with one type of cancer\, and even within tumors within a single patient\, making early cancer diagnosis\, accurate prognosis and treatment challenging. We take the view that all the varying biological factors influencing cancer ultimately lead to similar mechanical outcomes that define the disease – uncontrolled cell proliferation and tumor growth within the host tissue environment\, cell migration and invasion of neighboring tissues\, and formation of secondary neoplasms within the invaded tissues. Can the mechanics of these physical processes then shed light on key elements of cancer occurrence and progression? Can these mechanistic insights provide avenues for better prognosis and treatments of cancer? This talk will describe our efforts to understand the role of mechanics in cancer progression\, some interesting physical paradoxes that cancer progression presents and what biological insights if any can be gained from such understanding. \nAbout the Speaker: \nDr. Parag Katira is an Associate Professor in Mechanical Engineering and Associate Director of the Computational Sciences Research Center at San Diego State University. He is also the program coordinator for the Bioengineering Graduate Program at San Diego State University. Prior to his current position\, he was a Research Scientist at Columbia University in New York from 2013-2015 and a Postdoctoral Fellow at the University of Texas at Austin from 2009-2013. He completed his PhD. in Materials Science and Engineering from the University of Florida in 2009. His current research focuses on modeling active matter systems such as assemblies of driven cytoskeletal filaments\, cellular collectives on 2D and in 3D environments\, and tissue dynamics during processes such as wound-healing and cancer. His research is funded by grants from the US National Science Foundation\, Department of Defence Army Research Office and the National Institutes of Health. He was awarded the 2021 Outstanding Leadership in Engineering Award by the San Diego County Engineering Council for his efforts on transforming engineering education and training at San Diego State University.
URL:https://be.iisc.ac.in/event/seminar-by-dr-parag-katira-on-mechanics-of-cancer/
LOCATION:M Tech Classroom\, BSSE Annex
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20221205T110000
DTEND;TZID=UTC:20221205T120000
DTSTAMP:20260406T080551
CREATED:20221128T233152Z
LAST-MODIFIED:20221128T233152Z
UID:4392740-1670238000-1670241600@be.iisc.ac.in
SUMMARY:Seminar by Dr. Vinaya Simha on Lipodystrophy and Insulin Resistance
DESCRIPTION:Speaker Name and Affiliation: Dr. Vinaya Simha\, Mayo Clinic (currently Satish Dhawan visiting professor at IISc) \nSeminar Title: Lipodystrophy and Insulin Resistance: Lessons learned and to be learned \nAbstract: Lipodystrophy syndromes are a diverse group of congenital and acquired disorders characterized by selective fat loss and features of marked insulin resistance including early-onset diabetes\, hyperlipidemia and hepatic steatosis. Much progress has been made recently in understanding the molecular basis of fat loss and metabolic complications. It has also thrown light on the pathogenesis of insulin resistance in obesity and metabolic syndrome and the importance of adipocyte endocrine function. Recent studies focusing on muscle mitochondrial dysfunction in lipodystrophy may help to further elucidate mechanisms of insulin resistance contributing to diabetes and dyslipidemia. \nBrief Bio of Speaker: Prof. Simha is an Associate Professor of Medicine at the Mayo Clinic College of Medicine and Science and a Consultant in Endocrinology in the Department of Internal Medicine at Mayo Clinic\, Rochester\, Minnesota. He has won numerous awards\, the latest of which is the 2018 Laureate Award from the Mayo Clinic. He has been an active clinical practitioner and researcher\, specializing in diabetes and other endocrine disorders and their complications. He has been and is currently an investigator on several NIH grants and the lead investigator/director on clinical trials supported by the pharmaceutical industry.
URL:https://be.iisc.ac.in/event/seminar-by-dr-vinaya-simha-on-lipodystrophy-and-insulin-resistance/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20221202T150000
DTEND;TZID=UTC:20221202T160000
DTSTAMP:20260406T080551
CREATED:20221125T055815Z
LAST-MODIFIED:20221125T060318Z
UID:4392711-1669993200-1669996800@be.iisc.ac.in
SUMMARY:Guest Lecture by Dr. Andrew Holle on "Tight squeeze: Engineering confinement for mechanobiology research"
DESCRIPTION:Abstract:  \nSelf-induced cellular confinement has been shown to play a role in a wide variety of biological processes\, including cancer invasion and metastasis\, immune cell navigation\, and mechanosensitive gene expression and localization. However\, the ability of adult stem cells to enter tight confinements has been less studied\, despite the fact that stem cells are capable of finely tuned mechano-transduction\, must migrate from their home niche to their regenerative niche\, and have been shown to integrate past stimuli in a form of ‘mechanical memory’. Here\, we characterize the interstitial spaces in cleared tissue\, providing a physiological basis for the design of biomimetic microchannel devices. Next\, we show that adipose-derived stem cells (ASCs) and bone marrow stem cells (hMSCs) are capable of entering and permeating PDMS-based microchannels as narrow as 3 µm. Patterns of microchannel permeation as a function of width are similar to those found in cancer cells\, despite the fact that these stem cells are more well-spread and exhibit higher cell diameters. Both narrow and wide confinements were shown to induce an upregulation of the osteogenic differentiation marker CBFA1. Interestingly\, narrow confinements led to enhanced CBFA1 nuclear localization compared to wide channels\, suggesting that the level of confinement imposed upon a stem cell via its extracellular environment ultimately plays a role in differentiation. In conjunction with these changes in fate\, stem cells exposed to confinement also showed significant changes in epigenetic state as measured by H3K9Ac localization. Future work will ultimately discern if the migratory journey a stem cell undergoes during development and regeneration\, and the confinement it experiences along the way\, drive tissue-specific stem cell differentiation \nAbout the Speaker: \nDr. Andrew Holle is currently an Assistant Professor at the Department of Biomedical Engineering\, National University of Singapore (NUS) and the Principal Investigator at the Mechanobiology Institute\, NUS. He received Ph.D. at the University of California\, San Diego\, where he worked in Prof. Adam Engler’s Stem Cell Biology and Bioengineering group. He identified the mechanosensitive role of the focal adhesion protein vinculin in substrate stiffness-induced stem cell differentiation. Looking to explore the commonalities between stem cells and cancer mechanobiology\, he then joined Prof. Joachim Spatz’s Cellular Biophysics group at the Max Planck Institute for Medical Research (Stuttgart\, Germany). He used photolithography and microfluidics to build microchannel assays better to characterize cancer cell invasion and migration in confinement. His current work at the Mechanobiology Institute and in the NUS Biomedical Engineering department is focused on the role of confinement in mechanobiology\, with an emphasis on novel strategies for controlling stem cell differentiation.
URL:https://be.iisc.ac.in/event/guest-lecture-dr-andrew-holle-tight-squeeze-engineering-confinement-for-mechanobiology-research/
LOCATION:M Tech Classroom\, BSSE Annex
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20220926T143000
DTEND;TZID=Asia/Kolkata:20220926T153000
DTSTAMP:20260406T080551
CREATED:20220924T000728Z
LAST-MODIFIED:20220924T001126Z
UID:4392413-1664202600-1664206200@be.iisc.ac.in
SUMMARY:Guest Lecture by Dr. Jason T. George  on "Stochastic modeling of the tumor-immune interaction"
DESCRIPTION:Abstract: “Harnessing the adaptive immune system to recognize and eliminate cancer cells has ushered in T cell-based immunotherapies\, which have revolutionized cancer treatment by inducing durable remission for many patients. Due to the immense complexity of T cell immunotherapy\, nearly all attempts to improve these approaches and to expand their applications have been driven empirically. To predict treatment failure and optimize current therapies\, we must understand the dynamic interplay between an adaptive immune system and an evolving cancer population. My talk will describe stochastic modeling that our group has been actively developing\, which include random energy models of the T cell receptor-antigen interface developed to characterize immune recognition potential against tumor antigens\, and dynamical models of the interaction between an evolving cancer population and an adaptive immune system. \nAbout the speaker: Jason T. George is an assistant professor in the Department of Biomedical Engineering at Texas A&M University. His research interests lie at the intersection of engineering and applied mathematics\, where he focuses on developing dual theoretical and data-driven mathematical models to characterize cancer development and evasion with the goal of improving treatment outcomes. Prior to joining A&M\, Dr. George was a postdoctoral fellow in the Center for Theoretical Biological Physics at Rice University. He was a student in the Medical Scientist Training Program where he earned his M.D. at Baylor College of Medicine and Ph.D. in the Department of Bioengineering at Rice University under the mentorship of Herbert Levine. Prior to this\, Dr. George completed his undergraduate training at Texas A&M University\, where he earned a B.S. in Biomedical Engineering and a B.A. in Mathematics. Dr. George is the recipient of the CPRIT First-Time Tenure-Track Faculty Recruitment Award. His graduate thesis work was funded by a Ruth L. Kirschstein Fellowship through the NIH National Cancer Institute.
URL:https://be.iisc.ac.in/event/guest-lecture-by-dr-jason-t-george-on-stochastic-modeling-of-the-tumor-immune-interaction/
LOCATION:M Tech Classroom\, BSSE Annex
CATEGORIES:Seminar
ORGANIZER;CN="BSSE%20Seminar%20Team":MAILTO:seminars.bsse@iisc.ac.in
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220328T163000
DTEND;TZID=UTC:20220328T173000
DTSTAMP:20260406T080551
CREATED:20220327T221341Z
LAST-MODIFIED:20220327T221516Z
UID:4392186-1648485000-1648488600@be.iisc.ac.in
SUMMARY:Seminar: Microenvironment regulation of metastasis
DESCRIPTION:The Centre for BioSystems Science and Engineering (BSSE) cordially invites you to attend a departmental seminar. \n  \nSpeaker: Dr. Kandice Tanner\, National Cancer Institute\, NIH
URL:https://be.iisc.ac.in/event/seminar-microenvironment-regulation-of-metastasis/
LOCATION:Online
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220307T160000
DTEND;TZID=UTC:20220307T170000
DTSTAMP:20260406T080551
CREATED:20220305T231405Z
LAST-MODIFIED:20220305T231405Z
UID:4392176-1646668800-1646672400@be.iisc.ac.in
SUMMARY:Discoveries in natural light sensing and probing cellular dynamics: an interdisciplinary approach and a need for engineering in biology
DESCRIPTION:The Centre for BioSystems Science and Engineering (BSSE) cordially invites you to attend a departmental seminar.Speaker: Dr. Akash Gulyani\, Department of Biochemistry\, School of Life Sciences\, University of Hyderabad
URL:https://be.iisc.ac.in/event/discoveries-in-natural-light-sensing-and-probing-cellular-dynamics-an-interdisciplinary-approach-and-a-need-for-engineering-in-biology/
LOCATION:Online
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20220223T160000
DTEND;TZID=UTC:20220223T180000
DTSTAMP:20260406T080551
CREATED:20220221T043429Z
LAST-MODIFIED:20220221T043439Z
UID:4392095-1645632000-1645639200@be.iisc.ac.in
SUMMARY:Mechanobiology of Liver Cirrhosis: The Role of Hepatocytes in Fibrosis Progression
DESCRIPTION:The Centre for BioSystems Science and Engineering (BSSE) cordially invites you to attend an Annual Work Presentation. \nStudent: Anwesha Barua  (BSSE) \nAdvisors: Prof. G.K. Ananthasuresh (ME) and Prof. Saumitra Das (MCB)
URL:https://be.iisc.ac.in/event/mechanobiology-of-liver-cirrhosis-the-role-of-hepatocytes-in-fibrosis-progression/
LOCATION:Online
CATEGORIES:Announcement
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