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DTSTART:20230101T000000
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DTSTART;TZID=UTC:20230807T160000
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DTSTAMP:20260407T232103
CREATED:20230801T053041Z
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SUMMARY:Seminar by Dr. Bala (Balasubramanian) Venkatakrishnan\, titled "Be On Top Of Your Cells: Flow Cytometry In The Cell Manufacturing Suite"
DESCRIPTION:Title:   Be On Top Of Your Cells: Flow Cytometry In The Cell Manufacturing Suite \n About the Speaker: \nBala Venkatakrishnan is a protein biochemist with a background in structural virology. He has spent about 10 years in academia followed by a little over 6 in the biotech industry (contract-research\, pharma and a product based companies). He has a passion for science communication and people management as he seek to answer life’s important scientific and healthcare questions. He is been with Beckman Coulter for close to 2 years as part of their flow cytometry reagent R&D team. Outside the lab\, he passionately drive Beckman’s DE+I and sustainability efforts. \nAbstract: The large variety in flow cytometry applications (ranging from cell manufacturing to diagnostics) requires customized solutions to meet specific user needs. At Beckman Coulter Life Sciences\, we emphasize customer-centric design with a focus on addressing key pain points. This talk will be a walkthrough on a range of Beckman products (hardware\, software and reagents) that address flow cytometry needs in cell manufacturing and clinical research spaces. \n  \n 
URL:https://be.iisc.ac.in/event/seminar-by-dr-bala-balasubramanian-venkatakrishnan-titled-be-on-top-of-your-cells-flow-cytometry-in-the-cell-manufacturing-suite/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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DTSTART;TZID=UTC:20230814T160000
DTEND;TZID=UTC:20230814T170000
DTSTAMP:20260407T232103
CREATED:20230810T054142Z
LAST-MODIFIED:20230810T054142Z
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SUMMARY:Seminar by Dr. Sunil Laxman on “Economic principles of metabolic restoration in cells”
DESCRIPTION:Speaker: Dr. Sunil Laxman\, Associate Investigator\, DBT-in Stem\, Bangalore        \nTitle:    Economic principles of metabolic restoration in cells  \n About the Speaker: Sunil Laxman is an associate investigator at DBT-in Stem\, Bangalore. An old Bangalorean\, Sunil completed his BTech at CBT\, AU in Chennai\, and a Ph.D. at the University of Washington\, Seattle (with Prof. Joseph Beavo)\, where he developed an interest in principles of cell signaling. He went on to postdoctoral studies at UT Southwestern Medical Centre\, with Profs. Steven McKnight and Benjamin Tu\, which initiated interest in metabolism. The current goals of research in the Laxman lab are to identify the rules\, chemical logic\, and organizational principles of metabolic networks. Ongoing directions of research include understanding the formation and sensing of metabolites\, and systems-level principles of metabolic network organization. \nAbstract: Cell metabolism should be thought of as an economy\, which is organized into supply and demand blocks (of precursors and products). But to build frameworks for metabolic exchange between cells\, and how the evolution of metabolic/signalling pathways determines resource allocation strategies in cells. Findings from these studies are being integrated synthetic systems approaches for regenerative biology\, food\, and environmental biotechnology. The lab is supported by a DBT-Wellcome India Alliance Senior Fellowship\, and other support from DST\, DBT\, and the EMBO YIP/Global Investigator network. what can supply-demand analysis teach us? Quantitative considerations of supply and demand should reveal multiple organizations of cellular responses. I will explore this central concept in this seminar\, through two ongoing studies. In the first\, we address how cells differentially prioritize the restoration of distinct amino acids\, upon disrupting their supply\, and construct a logic based on individual amino acid costs as well as composite demand. We find that cells employ a conserved strategy guided by the law of demand\, to prioritize amino acid restorations upon transient limitation. In the second part of this seminar\, we uncover how cells differentially treat amino acids that are internally available\, vs those that accumulate externally. Quantitatively\, these internal and external amounts can differ by orders of magnitude\, and do not universally function as ‘public goods’. Distinct amino acids\, based on ease of availability as well as functional requirements\, can function either as contextually utilized public goods\, or carefully protected\, privatized resources that are banked for anticipated future requirements. I will end with speculation on how quantitative analyses of demand and supply can explain cellular resource allocation strategies in different environments. \n 
URL:https://be.iisc.ac.in/event/seminar-by-dr-sunil-laxman-on-economic-principles-of-metabolic-restoration-in-cells/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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