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X-WR-CALDESC:Events for Department of Bioengineering
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DTSTART:20240101T000000
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DTSTART;TZID=UTC:20240118T140000
DTEND;TZID=UTC:20240118T150000
DTSTAMP:20260407T165443
CREATED:20240115T234106Z
LAST-MODIFIED:20240115T234106Z
UID:4394455-1705586400-1705590000@be.iisc.ac.in
SUMMARY:BE Seminar titled Employing Common Ions And Molecules For Sustainable Clean Water by Dr. Swathy J. R.
DESCRIPTION:Title: EMPLOYING COMMON IONS AND MOLECULES FOR SUSTAINABLE CLEAN WATER \nSpeaker: Dr. Swathy J. R. \nAbstract: Despite the existence of several innovative solutions in the field of water purification\, successful technologies continue to encounter significant challenges. Many of these technologies lack sustainability and durability due to frequent manual interventions and associated expenses. While various global entities\, both governmental and non-governmental\, are striving to provide clean water to those in need and are evaluating the water demand in the context of climate change\, industries are struggling to find alternative options that are stable\, cost-effective\, uninterrupted\, and reliable to address this critical issue. For these technologies to achieve sustainability and widespread adoption\, they must not only be energy-efficient\, rapid\, and affordable\, but also environmentally benign. \nThe objective of the presentation is to emphasize the synergistic effects of ions on biological systems and discuss the design of materials that can sustainably release both anions and cations. The talk will present the use of carbonates as one of the dimension to counteract cytotoxicity induced by arsenic. Additionally\, insights into the application of ambient mass spectrometry as a tool for detecting biofouling on water purification materials will be shared during this session. \nBiography: Dr. Swathy is a proactive researcher with an industrial exposure and holds her interdisciplinary doctoral degree from IIT MADRAS under the guidance of Padmashri. Prof. T. Pradeep (Chemistry)\, Prof. Ligy Philip (Civil Engr.) on the topic\, “Employing Common Ions and Molecules for Sustainable Clean Water”. Further\, she is now heading the Validation wing at R&D\, Eureka Forbes Limited\, monitoring technology development\, institutional collaborations\, bench-marking and field trial data processing. She drives open innovation and is a part of cross functional ratification team to develop robust strategies to support product applications. \nShe has a demonstrated history of technology transfer and application oriented research related to drinking water purification. Swathy’s research interests are in water chemistry & microbiology interface focusing on commercially viable and environmentally benign advanced materials\, their Ionic interaction in water\, and its analytical perspectives. Her work experience includes design\, development\, optimization\, scale-up and ratification of commercial water purification technologies to address water pollution around the world. Analytical expertise to understand the performance of technologies and designing digital water monitoring systems are some of her highlighted deliveries. \nShe has 16+ Indian\, US and WIPO patents and 10 high impact research publications in peer reviewed journals (Total impact factor of 81.6)\, in the area of sustainable solutions for drinking water purification. Her recent work on reducing the water wastage from Reverse osmosis technology has been incorporated into the Aquaguard® products under the names Aquaguard® Crystal NXT HR RO+UV+MTDS and Aquaguard® Aura HR RO+UV+MTDS\, and are successful in the Indian market with diverse water conditions for the past 2 years. \nShe has also been elected as a talent to represent SDG – 6 (water)\, by the UNLEASH global community. She is a part of sustainability development team at Eureka Forbes Limited\, for handling the corporate’s sustainability projects. She is presently serving as a subject matter expert in industry’s pollution control committee. \nHer patented work titled ‘Anion effect on disinfection of silver’ was sold to a “US based Nanoholding Inc.\, a Delaware corporation” for its commercialization. Her work titled “Rollpure”\, a rolling water purifier won the prestigious Gandhian Young Technological Innovation (GYTI) Award from the honorable President of India.
URL:https://be.iisc.ac.in/event/be-seminar-titled-employing-common-ions-and-molecules-for-sustainable-clean-water-by-dr-swathy-j-r/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=UTC:20240123T110000
DTEND;TZID=UTC:20240123T120000
DTSTAMP:20260407T165443
CREATED:20240121T211655Z
LAST-MODIFIED:20240121T211655Z
UID:4394460-1706007600-1706011200@be.iisc.ac.in
SUMMARY:BE Seminar on A dual-fluorescent reporter to identify mechanisms regulating the epithelial-to-mesenchymal transition in breast cancer
DESCRIPTION:Speaker: Prof. Michael Toneff\, PhD\, Departments of Biology and Biochemistry\, Widener University. \nTitle: A dual-fluorescent reporter to identify mechanisms regulating the epithelial-to-mesenchymal transition in breast cancer. \nAbstract: The epithelial-mesenchymal transition (EMT) is a developmental and wound-healing process whereby stationary epithelial cells undergo a reversible phenotypic change to a motile\, mesenchymal-like state. EMT can aberrantly occur in carcinoma cells and is strongly linked to therapeutic resistance. Moreover\, the ability of carcinoma cells to exhibit plasticity between epithelial and mesenchymal states may be critical for carcinoma cells to adapt to the different stages of metastatic progression. E-cadherin is an effector of the epithelial phenotype\, and its expression is lost during EMT. ZEB1 is a transcription factor that promotes EMT via repression of E-cadherin and other epithelial genes. We developed a lentivirus-based\, dual-fluorescent reporter that reflects the state of E-cadherin transcription and ZEB1 post-transcriptional regulation by the microRNA 200 family. This dual reporter enables the real-time identification of live cells in an epithelial\, mesenchymal\, or hybrid state\, thus facilitating the study of the dynamic EMT phenomenon. Using this reporter\, we identified several compounds that can reverse the mesenchymal phenotypes associated with poor breast cancer outcomes. Furthermore\, we have identified epigenetic mechanisms\, including DNA methylation and histone acetylation\, as potentially critical determinants of complete vs. partial EMT states. In this talk\, I will discuss how we have used our reporter to better understand how breast cancer cells achieve aggressive mesenchymal properties and to identify potential therapeutic targets to better treat this deadly disease. \nBiography: Dr. Michael Toneff received his BS in Biology at Ohio State University in Columbus\, Ohio where he became interested in someday teaching biology to undergraduates and performing cancer research. He moved to Houston\, Texas and received his PhD at Baylor College of Medicine (BCM) in the laboratory of Dr. Yi Li\, where he studied the hormone dependency of breast cancer initiation. Dr. Toneff was then awarded the NIH-funded IRACDA Postdoctoral Fellowship that combined post-doctoral research with teaching at minority-serving undergraduate institutions. Dr. Toneff joined the laboratory of Dr. Jeffrey Rosen at BCM as an IRACDA fellow. In the Rosen laboratory\, he studied the epithelial-mesenchymal transition (EMT) in breast cancer where he developed the Z-cad dual fluorescent reporter to identify the EMT state of live cells. It was during this time that he first identified epigenetic mechanisms as a determinant of EMT states in breast cancer. During this time\, he also taught several cell and molecular biology courses at the University of Houston-Downtown. Dr. Toneff is currently an Associate Professor of Biology at Widener University\, a primarily undergraduate teaching institution just outside of Philadelphia\, Pennsylvania. At Widener\, he teaches both introductory and upper division cell and molecular biology courses. Moreover\, he has continued to study EMT regulatory mechanisms in collaboration with others\, including Dr. Mohit Jolly at IISc\, while training undergraduate students in his research laboratory.
URL:https://be.iisc.ac.in/event/be-seminar-on-a-dual-fluorescent-reporter-to-identify-mechanisms-regulating-the-epithelial-to-mesenchymal-transition-in-breast-cancer/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=UTC:20240131T160000
DTEND;TZID=UTC:20240131T170000
DTSTAMP:20260407T165443
CREATED:20240123T224407Z
LAST-MODIFIED:20240123T224407Z
UID:4394470-1706716800-1706720400@be.iisc.ac.in
SUMMARY:BE Seminar: Living Therapeutic Materials – Hydrogel encapsulated bacteria for smart drug delivery
DESCRIPTION:Speaker: Dr. Shrikrishnan Sankaran \nTitle: Living Therapeutic Materials – Hydrogel encapsulated bacteria for smart drug delivery \nAbstract: Living therapeutics is a rapidly growing field in which live microorganisms are engineered to produce and deliver drugs right within the body. A unique advantage of this approach is that the organisms can be programmed with smart functions to sense and process disease-associated stimuli from the patient and regulate the drugs they produce. Probiotic or host-friendly bacteria engineered to sense patients’ needs and deliver drugs in response are showing early promise in treating chronic diseases but two major challenges are slowing progress of this approach – (i) scarcity of genetic tools to program sensing functions in most medically relevant probiotics like lactobacilli & (ii) unpredictability of drug doses due to variable bacterial survival in the body. In this presentation\, I will share my group’s multi-disciplinary approach to overcome these challenges by (i) expanding the poorly equipped genetic toolbox of probiotic lactobacilli with new gene regulatory and plasmid retention modules[1]. and (ii) encapsulating the bacteria in mechanically tunable hydrogels that can controllably sustain bacterial activity[2\,3]. The engineered bacteria combined with hydrogels form living therapeutic materials\, in which control over bacterial functions can be exerted through both genetic and mechanical means. Novel fundamental insights and application-oriented advances from our published and ongoing work will be presented. \nAbout the Speaker: Dr. Shrikrishnan Sankaran is the head of the Bio programmable Materials research group\, he combines bacterial engineering with biomaterials to develop engineered living materials for therapeutic and environmental applications. His group genetically programs beneficial bacteria with sensing\, catalytic and therapeutic functions. These bacteria are encapsulated in soft materials like hydrogels to create living devices that perform these advanced functions long-term at low-costs and in an eco-friendly manner. Currently\, a major focus of the group is expanding the genetic toolkit of non-model probiotic and commensal bacteria to achieve in situ controllable drug delivery.
URL:https://be.iisc.ac.in/event/be-seminar-living-therapeutic-materials-hydrogel-encapsulated-bacteria-for-smart-drug-delivery/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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