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X-WR-CALDESC:Events for Department of Bioengineering
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BEGIN:VEVENT
DTSTART;TZID=UTC:20240304T160000
DTEND;TZID=UTC:20240304T170000
DTSTAMP:20260407T195952
CREATED:20240227T230448Z
LAST-MODIFIED:20240227T230448Z
UID:4394612-1709568000-1709571600@be.iisc.ac.in
SUMMARY:BE Seminar: A Mathematical Odyssey: From Brain Biomechanics to Cancer Therapeutics
DESCRIPTION:Speaker: Dr Siv Sivaloganathan \nTitle: A Mathematical Odyssey: From Brain Biomechanics to Cancer Therapeutics \nAbstract: In this talk\, I will touch on some of the successes and obstacles encountered in the application of mathematics to the biomedical sciences. I hope to illustrate this with examples from hydrocephalus\, tumorigenesis\, and the utilization of High-Intensity Focused Ultrasound (HIFU) for cancer treatment. Mathematical models have proven instrumental in optimizing hydrocephalus treatments\, and helped unveil some of the intricacies of tumor development and treatment response. Moreover\, they continue to play a major role in the evolution of non-invasive HIFU as a strategy for cancer therapeutics. These examples underscore the profound impact of mathematical modeling in understanding physiological dysfunction and shaping effective interventions in clinical medicine. \nAbout The Speaker: Dr. Siv Sivaloganathan is a Professor at the Department of Applied Mathematics\, University of Waterloo\, and heads the Biomedical Research Group there. Since 2004\, he is also the Director of the Centre for Mathematical Medicine at Fields Institute in Toronto. He obtained his PhD from Oxford University\, and has extensively trained multiple PhD students and postdoctoral fellows in mathematical biology in past 25 years. His expertise is in the field of biomechanics and the development of mathematical models of clinical conditions and diseases using continuum mechanics. He has been Principal Investigator on a number of grants including NSERC Collaborative Health and Hospital for Sick Children Foundation. \n 
URL:https://be.iisc.ac.in/event/be-seminar-a-mathematical-odyssey-from-brain-biomechanics-to-cancer-therapeutics/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=UTC:20240306T160000
DTEND;TZID=UTC:20240306T170000
DTSTAMP:20260407T195952
CREATED:20240229T005853Z
LAST-MODIFIED:20240229T005853Z
UID:4394628-1709740800-1709744400@be.iisc.ac.in
SUMMARY:BE: Seminar\, Mechanonucleargenomics
DESCRIPTION:Speaker: Kundan Sengupta \nTitle: Mechanonucleargenomics \nAbstract: It is well established that chromosomes occupy a unique sub-volume in the interphase nucleus referred to as Chromosome Territories. Remarkably\, chromosome territories are organized in a non-random manner with gene rich chromosome territories toward the center and gene poor chromosome territories proximal to the nuclear border. What are the molecular mechanisms that organize chromosome territories in a non-random manner in the nucleus? To address this question\, we subjected cells to softer hydrogels with stiffness ranging from ~2 to ~55 kPa\, while collagen coated glass coverslips (~1 GPa) served as reference. Cells exposed to softer substrates\, showed an increase in surface area\, over time. \nFurthermore\, transcriptomic analyses involving RNA-Seq revealed a strikingly altered transcriptome. Interestingly\, cells on softer matrices also showed a significantly altered configuration in the otherwise highly invariant locations of chromosome territories. Remarkably\, nuclear envelope proteins – lamins and LINC (linker of nucleoskeleton and cytoskeleton) complex\, mislocalized into the nuclear interior. Interestingly\, the nuclear organization of active and inactive histone marks was also altered along with the activation of Emerin phosphorylation – the inhibition of which attenuated the relay of mechanochemical signals into the nucleus\, abrogating the movement of chromosome territories in cells exposed to softer matrices. Taken together\, our studies highlight a remarkable plasticity\, adaptability and resilience of the nucleus to counter and protect genome organization and function from external mechanical forces. \nAbout the Speaker: Kundan Sengupta completed BSc\, MSc from Bangalore University. PhD from TIFR\, Mumbai. Postdoc from NCI/NIH. Currently\, Dr. Kundan is a faculty at IISER-Pune.
URL:https://be.iisc.ac.in/event/be-seminar-mechanonucleargenomics/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20240311T160000
DTEND;TZID=UTC:20240311T170000
DTSTAMP:20260407T195952
CREATED:20240304T231811Z
LAST-MODIFIED:20240304T231811Z
UID:4394639-1710172800-1710176400@be.iisc.ac.in
SUMMARY:BE Seminar by Dr. Vanita Rahman titled The Role of Nutrition in the Prevention and Reversal of Type 2 Diabetes
DESCRIPTION:Speaker:  Dr. Vanita Rahman \nTitle: The Role of Nutrition in the Prevention and Reversal of Type 2 Diabetes \nAbstract: Non-communicable diseases\, such as diabetes\, obesity\, and cardiovascular disease\, are rising at an alarming rate in India due to the unique genetic risks of the Indian population and the westernization of the Indian diet and lifestyle. The current prevalence of obesity and diabetes in India is 40 and 16 percent\, respectively. Diabetes is associated with significant morbidity and mortality\, and heightened risk of cardiovascular disease\, which is the leading cause of death in India. Although cardiometabolic conditions – diabetes\, cardiovascular disease\, dyslipidemia\, obesity – are strongly influenced by dietary factors\, the use of dietary interventions in often eclipsed by the use of medications in clinical practice. \nIn clinical trials\, plant-based dietary interventions have led to lower cholesterol levels\, improved glycemic control\, sustainable weight loss\, and\, as part of a program including other lifestyle changes\, reversal of coronary artery disease. Despite the benefits of plant-based diets\, most physicians do not prescribe plant-based diets due to a lack of knowledge\, time constraints\, or concerns regarding patient interest or adherence. \nDr. Rahman will review the unique genetic vulnerability of the Indian population to diabetes and other cardiometabolic conditions\, and the research evidence regarding the role of plant-based diets in the prevention and reversal of diabetes\, obesity\, and cardiovascular disease. She will also provide practical tips and resources to help the attendees make meaningful dietary changes. \nAbout The Speaker:  Dr. Vanita Rahman was born in New Delhi and spent her school-age years in Bangalore attending the New Horizon Public School. She completed her undergraduate and medical degrees at the University of Virginia. She is currently the clinic director at the Physicians Committee for Responsible Medicine\, where she leads clinical research\, facilitates nutrition education programs\, and provides patient care with an emphasis on nutrition. Dr. Rahman is the principal investigator in two clinical trials exploring the role of Zoom-based nutrition education in obesity and diabetes management. She is also a clinical instructor in medicine at the George Washington University School of Medicine and frequently speaks at international conferences about the role of nutrition in chronic disease. Dr. Rahman is a board-certified internal medicine and lifestyle medicine physician\, certified nutritionist\, and personal trainer. She has authored several books on plant-based nutrition and published articles in peer-reviewed medical journals. \nThe Physicians Committee for Responsible Medicine is a nonprofit organization in Washington\, D.C.\, that conducts clinical research and provides nutrition education. Physicians Committee experts have been principal investigators in dozens of clinical trials and published original research in peer-reviewed medical journals\, including JAMA Network.
URL:https://be.iisc.ac.in/event/be-seminar-by-dr-vanita-rahman-titled-the-role-of-nutrition-in-the-prevention-and-reversal-of-type-2-diabetes/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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