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X-ORIGINAL-URL:https://be.iisc.ac.in
X-WR-CALDESC:Events for Department of Bioengineering
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BEGIN:VEVENT
DTSTART;TZID=UTC:20240408T160000
DTEND;TZID=UTC:20240408T170000
DTSTAMP:20260408T004416
CREATED:20240403T205438Z
LAST-MODIFIED:20240403T205438Z
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SUMMARY:BE Seminar: Machine Learning Approaches To The Interpretation Of the Tumor Microenvironment Using Spatial Immuno-profiling & Spatial Transcriptomics
DESCRIPTION:Speaker: Prof. Arvind Rao \nTitle: Machine Learning Approaches To The Interpretation Of the Tumor Microenvironment Using Spatial Immuno-profiling & Spatial Transcriptomics \nAbstract: Spatial profiling technologies like hyper-plex immunostaining in tissue\, spatial transcriptomics\, etc. have the potential to enable a multi-factorial\, multi-modal characterization of the tissue microenvironment. Scalable\, quantitative methods to analyze and interpret spatial patterns of protein staining and gene expression are required to understand cell-cell relationships in the context of local variations in tissue structure. Objective scoring methods inspired by recent advances in statistics and machine learning can serve to aid the interpretation of these datasets\, as well as their integration with other\, companion data like genomics. In this talk\, we will discuss elements of spatial profiling from multiple studies as well as paradigms from statistics and machine learning in the context of these problems. This talk will also discuss the use of AI/ML and spatial analytics of the tumor microenvironment to derive spatial biomarkers of immunotherapy.\nAbout the Speaker: Dr. Arvind Rao is an Associate Professor in the Department of Computational Medicine and Bioinformatics at the University of Michigan. His group uses image analysis and machine learning methods to link image-derived phenotypes with genetic data\, across biological scale (i.e. single cell\, tissue\, and radiology data). Such methods have found application in radiogenomics\, drug repurposing based on phenotypic screens\, and spatial profiling in tissue\, as well as in spatial transcriptomics. Dr. Arvind received his Ph.D. in Electrical Engineering and Bioinformatics from the University of Michigan\, specializing in transcriptional genomics\, and was a Lane Postdoctoral Fellow at Carnegie Mellon University\, specializing in bioimage informatics. \n 
URL:https://be.iisc.ac.in/event/be-seminar-machine-learning-approaches-to-the-interpretation-of-the-tumor-microenvironment-using-spatial-immuno-profiling-spatial-transcriptomics/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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DTSTART;TZID=UTC:20240425T143000
DTEND;TZID=UTC:20240425T153000
DTSTAMP:20260408T004416
CREATED:20240427T142142Z
LAST-MODIFIED:20240427T181804Z
UID:4394729-1714055400-1714059000@be.iisc.ac.in
SUMMARY:BE Seminar: Surgical Robotics: A Journey Across Scales
DESCRIPTION:Speaker: Prof. Sarthak Misra\nProf. Satish Dhawan Visiting Chair Professor \nDate: 25th April 2024 \nTime: 2.30 pm – 3.30 pm \nVenue: DBG Seminar Hall \nTitle: Surgical Robotics: A Journey Across Scales \nSummary: This talk will provide an overview of ongoing work at the Surgical Robotics Laboratory. It covers topics ranging from the design of macro-scale flexible/continuum surgical instruments to the fabrication and control of futuristic medical micro-robots. Prof. Misra has been recently invited to IISc as a Prof. Satish Dhawan Visiting Chair Professor. This is his first lecture as part of his appointment at IISc. \nAbout the Speaker: Prof. Sarthak Misra joined the University of Twente in 2009. He is currently a Full Professor in the Department of Biomechanical Engineering within the Faculty of Engineering Technology. He is also affiliated with the Department of Biomaterials and Biomedical Technology\, University of Groningen\, and University Medical Center Groningen. He leads the Surgical Robotics Laboratory. Prof. Sarthak obtained his doctoral degree in the Department of Mechanical Engineering at the Johns Hopkins University\, Baltimore\, USA. Prior to commencing his studies at Johns Hopkins\, he worked for three years as a dynamics and controls analyst at MacDonald Dettwiler and Associates on the International Space Station Program. Prof. Sarthak received his Master of Engineering degree in Mechanical Engineering from McGill University\, Montreal\, Canada. He is the recipient of the European Research Council (ERC) Consolidator\, Starting and Proof-of-Concept grants\, Netherlands Organization for Scientific Research (NWO) VENI and VIDI awards\, Link Foundation fellowship\, McGill Major fellowship\, and NASA Space Flight Awareness award. He is the co-chair of the IEEE Robotics and Automation Society Technical Committee on Surgical Robotics\, and area co-chair of the IFAC Technical Committee on Biological and Medical Systems. Sarthak’s broad research interests are primarily in the area of applied mechanics at both macro and micro scales. He is interested in the modeling and control of electro-mechanical systems with applications to medical robotics.
URL:https://be.iisc.ac.in/event/be-seminar-surgical-robotics-a-journey-across-scales/
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=UTC:20240425T160000
DTEND;TZID=UTC:20240425T170000
DTSTAMP:20260408T004416
CREATED:20240426T141255Z
LAST-MODIFIED:20240426T141255Z
UID:4394726-1714060800-1714064400@be.iisc.ac.in
SUMMARY:BE Seminar: The story of giant bacteriophage phiKZ and its potential usage as antimicrobials source
DESCRIPTION:Speaker: Maria Yakunina \nLeader of research group\, \nLaboratory of molecular microbiology\, Institute of Nanobiotechnologies\, Peter the Great St.Petersburg Polytechnic University \nTitle: The story of giant bacteriophage phiKZ and its potential usage as antimicrobials source \nAbstract: Bacteriophages are viruses that infect bacteria\, serving as their natural enemies and our potential allies. Due to the constant arms race occurring in the microcosm\, bacteriophages possess a vast array of tools to invade bacterial cells and utilize them for reproduction. In the seminar\, I will discuss the giant bacteriophage phiKZ\, which fundamentally alters the bacterial cell during infection. I will also talk about our current research focused on discovering the mechanisms through which the phage halts the life of a bacterial cell and how we can apply this knowledge. \nAbout the speaker: Maria Yakunina is a leader of the laboratory of molecular microbiology at the Institute of Nanobiotechnologies\, Peter the Great St. Petersburg Polytechnic University\, Russia.
URL:https://be.iisc.ac.in/event/be-seminar-the-story-of-giant-bacteriophage-phikz-and-its-potential-usage-as-antimicrobials-source/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=UTC:20240429T110000
DTEND;TZID=UTC:20240429T123000
DTSTAMP:20260408T004416
CREATED:20240429T020029Z
LAST-MODIFIED:20240429T020029Z
UID:4394733-1714388400-1714393800@be.iisc.ac.in
SUMMARY:BE Seminar: All Wired Up: Harnessing Protein Polymers for Medicine and Nanotechnology
DESCRIPTION:Speaker: Dr. Aarat P. Kalra\nIIT Delhi \nTitle: All Wired Up: Harnessing Protein Polymers for Medicine and Nanotechnology \nAbstract: The successful interfacing of biochemistry with electronics is one of the grand challenges of nanotechnology. Biodegradable and biocompatible materials with structural integrity\, that can perform mixed electronic and ionic roles are required for the development of the next generation of nanodevices. The interface of electronics and biochemistry is also crucial for medicine\, with electric and magnetic field-based therapies being used for cancer treatment and wound healing. \nInside the eukaryotic cell\, protein polymers such as microtubules and actin filaments play structural roles such as maintaining cell shape and orchestrating cell division. Short intermolecular distances between aromatic amino acids\, the presence of a highly negative surface charge\, and the structural regularity of the ordered protein ‘lattice’ allow the emergence of interesting properties in both protein polymers. Thus\, microtubules and actin filaments are interesting candidates for use in biodegradable nanodevices\, while also acting as the potential intracellular targets of electric field-based therapies. \nThe talk will focus on experiments revealing the nontrivial photophysical and electrostatic properties of microtubules. Our experiments reveal that energy can migrate by diffusive energy transfer over unexpectedly large distances (6.6 nm) in microtubules. We find that conventional Förster theory predicts a diffusion length of only ~2.3 nm; insufficient to explain our observations. Introducing the anesthetics etomidate and isoflurane decreases the observed energy diffusion length. We find significantly higher diffusion lengths when other mechanisms of energy transfer are considered. Collectively\, our work shows that it is worth considering protein polymers for ultraviolet light-harvesting systems. Microtubules and actin filaments also have highly negatively charged surfaces\, allowing them to store and possibly conduct ions. Our experiments on microtubules in solution show that they lowered their local pH value by as much as one unit on the pH scale and that they increased solution capacitance. This behavior indicates the potential of microtubules as charge storage devices both inside the cell and outside it\, within protein-based electronic devices. \nAbout the Speaker: Dr. Aarat Kalra is an Assistant Professor at the Centre for Biomedical Engineering at the Indian Institute of Technology\, Delhi\, and at the Department of Biomedical Engineering at the All India Institute of Medical Sciences\, New Delhi. \nHe completed his Bachelor of Science (B.Sc. (Hons.) with distinction from Dayal Bagh Educational Institute (Agra\, India) in chemistry\, a Master of Science (M.Sc.) from McGill University in biology\, and a Doctor of Philosophy (Ph.D.) with Prof. Jack Tuszynski at the University of Alberta in physics. Thereafter\, he worked as a postdoctoral researcher at Princeton University with Prof. Gregory Scholes\, publishing transformative work on microtubule electronics. \nDuring his doctoral work\, he was awarded the prestigious Alberta Innovates Graduate Student Scholarship and the micro-nano technology (MNT) Award (two times) over the course of his Ph.D. His work has shown that microtubules are unexpectedly effective light harvesters\, changing their photophysical properties upon small-molecule binding. This work has been published by ACS Central Science\, on the front cover of the March 2023 issue. He was invited to present a talk at Google in 2022\, as part of a conference titled ‘Is Our Brain a Quantum Computer?’ At IIT Delhi\, Dr. Kalra is a recipient of the Young Faculty Incentive Fellowship (YFIF). \nDr. Kalra’s work on microtubules has opened several new research directions and has been featured twice in the scientific magazine The New Scientist and recently in the Indian daily Hindustan Times.
URL:https://be.iisc.ac.in/event/be-seminar-all-wired-up-harnessing-protein-polymers-for-medicine-and-nanotechnology/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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