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X-WR-CALNAME:Department of Bioengineering
X-ORIGINAL-URL:https://be.iisc.ac.in
X-WR-CALDESC:Events for Department of Bioengineering
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BEGIN:VTIMEZONE
TZID:Asia/Kolkata
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TZOFFSETFROM:+0530
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DTSTART:20240101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20240801T150000
DTEND;TZID=Asia/Kolkata:20240801T160000
DTSTAMP:20260412T200609
CREATED:20240731T061236Z
LAST-MODIFIED:20240731T061236Z
UID:4394986-1722524400-1722528000@be.iisc.ac.in
SUMMARY:BE Seminar titled "Next-Generation Solutions in medicine: Overcoming Drug Resistance in Cancer" by Dr. Raghuraman Kannan
DESCRIPTION:Title: NEXT-GENERATION SOLUTIONS IN MEDICINE: OVERCOMING DRUG RESISTANCE IN CANCER. \nAbstract: Research in my laboratories is focused on uncovering the underlying root causes of cancer’s resistance to drugs. Specifically\, the work aims to identify and validate the mechanisms that drive this resistance. After elucidating the mechanism\, we have designed new nano-delivery devices specific to the target to improve the effectiveness of FDA-approved treatments by restoring tumor sensitivity. We have made significant progress in recent years\, including identifying a new “dual therapeutic pair” to overcome the resistance for the first time. We have also engineered stimuli-responsive nano-delivery devices to deliver more drugs to drug-resistant tumors and developed a novel class of material called Gelasomes for RNA therapy. In this seminar\, I will present details about the successes\, challenges\, and prospects of the above-listed projects. \nAbout the Speaker: Dr. Kannan is a faculty of Radiology and Bioengineering at the University of Missouri (MU) and has been a faculty member at MU since 2005. He leads the program on clinical translation of nanomaterials at MU. He received his M.S. degree in chemistry from the Indian Institute of Technology at Madras in 1993 and his Ph.D. degree in chemistry\, from the Indian Institute of Science in 1999. Dr. Kannan’s current research focuses on the following areas: § Oncology and Immuno-Oncology: Developing drugs to overcome drug resistance in cancer. Dr. Kannan’s work includes the study of AXL inhibition\, siRNA therapeutics\, and the tumor immune microenvironment in lung and ovarian cancer. § Nanomedicine: Designing and developing novel supraparticle systems\, including the Gold-Gelasomes and supraparticle self-assembly for targeted drug delivery and reduced toxicity in cancer treatment. § Medical Imaging and Diagnostics: Developing sensors for early detection of diabetic retinopathy and a near-infrared (NIR) imaging camera for cardiac imaging. Dr. Kannan is currently leading the NIH-supported “Clinical translational of nanomedicine” project with the aim of treating human cancer patients in the year 2027. As of now\, Dr. Kannan holds 23 patents and patent applications published and licensed. His patent portfolio spans across gene delivery systems\, CRISPR\, nanotechnology\, and medical imaging devices\, contributing significantly to advancements in medical science and technology. Translational Research: Dr. Kannan has founded multiple companies that focus on translating his research into practical medical applications\, bridging the gap between laboratory discoveries and clinical solutions. Dr. Kannan is a co-founder of four start-up companies based on his research. Two of his companies have raised several million-dollar investments from pharmaceutical companies. Education: Dr. Kannan is actively involved in developing new courses in Biomedical innovation and entrepreneurship; classroom teaching of basic principles of drug resistance in oncology; developing new laboratory experiments to provide hands-on experience to students; mentoring undergraduate\, graduate\, and post-doctoral fellows; and providing research opportunities to K-12 students in nanomedicine.
URL:https://be.iisc.ac.in/event/be-seminar-titled-next-generation-solutions-in-medicine-overcoming-drug-resistance-in-cancer-by-dr-raghuraman-kannan/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20240805T160000
DTEND;TZID=Asia/Kolkata:20240805T170000
DTSTAMP:20260412T200609
CREATED:20240805T042919Z
LAST-MODIFIED:20240805T042919Z
UID:4394998-1722873600-1722877200@be.iisc.ac.in
SUMMARY:BE Seminar: Self-Powered Devices Based on Triboelectrification by Prof. Zong-Hong Lin
DESCRIPTION:Title: Self-Powered Devices Based on Triboelectrification \nSpeaker: Prof. Zong-Hong Lin  \n National Taiwan University \nAbstract: Designing devices with self-powered sensing function has become a popular research field since its emergence in recent decades. Triboelectrification occurs when two materials come into contact with each other\, causing charge transfer that leads to oppositely charged surfaces; the amount of charge transfer varies depending on material composition. By combining triboelectrification with electrostatic induction\, relevant devices can be designed. If used for energy collection purposes\, scientists generally refer to them as Triboelectric Nanogenerators (TENGs); but if used for self-powered sensing purposes\, scientists call them Triboelectric Nanosensors (TENSs). In our previous research on TENSs\, we demonstrated the concept of selective detection of some targets by specific materials or their surface-modified probes. When the targets are adsorbing or binding to the surface\, different electrical output signals will be generated compared to before\, and these changes can be used for qualitative and quantitative analysis of the targets. In the past few years\, we have further developed solid-liquid TENSs for measuring targets such as metal ions\, small molecules\, proteins\, and microorganisms. Compared with our previously developed solid-solid TENSs\, we have not only improved several shortcomings but also established sensing mechanism and working principle which are very important research achievements in this field. We also look forward to expanding the applications of the solid-liquid TENSs in the near future. \nAbout the Speaker: Dr. Zong-Hong Lin received his PhD from the National Taiwan University (NTU) in 2009 and continued with his postdoctoral research at the NTU and Georgia Tech during the years of 2010-2014. Subsequently\, Dr. Lin joined the Institute of Biomedical Engineering\, National Tsing Hua University (NTHU) as an Assistant Professor in 2014 and was successfully promoted to Associate Professor and Full Professor in 2017 and 2021\, respectively. At the same time\, Dr. Lin was also an adjunct faculty at the Department of Power Mechanical Engineering and the Department of Chemistry. In 2023\, he moved to the Department of Biomedical Engineering at NTU. He has published more than 160 SCI papers (sum of the times cited: 15990\, h-index: 62)\, as well as received recognition for his research contribution\, such as CHEN-YUNG Chair Professor (2023) of NTU\, Academic Excellence Award\, College of Engineering of NTU (2023)\, Fellow of the Royal Society of Chemistry (2022)\, Outstanding Research). Award of the Taiwan National Science and Technology Council (NSTC) (2024)\, Future Tech Award of the Taiwan NSTC (2021\, 2022 and 2023)\, Ta-You Wu Memorial Award of the Taiwan NSTC (2021)\, Young Scholar Fellowship of the Taiwan NSTC (2020)\, IEEE-NANOMED New Innovator Award (2019) and Young Investigator Award of the NTHU (2018).
URL:https://be.iisc.ac.in/event/be-seminar-self-powered-devices-based-on-triboelectrification-by-prof-zong-hong-lin/
LOCATION:DBG Seminar Hall\, 1st Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20240806T160000
DTEND;TZID=Asia/Kolkata:20240806T170000
DTSTAMP:20260412T200609
CREATED:20240805T030229Z
LAST-MODIFIED:20240805T030229Z
UID:4394996-1722960000-1722963600@be.iisc.ac.in
SUMMARY:BE & DBG Seminar titled "Loss of tissue structure in cancer: a mechanobiological perspective." by Prof. Tanmay Lele
DESCRIPTION:The Department of Bioengineering (BE) and Department of Developmental Biology and Genetics (DBG) cordially invites you to attend a Seminar \nSpeaker: Prof. Tanmay Lele \nDepartment of Biomedical Engineering\, Texas A&M University\, USA \nTitle: Loss of tissue structure in cancer: a mechanobiological perspective \nAbstract: In glandular epithelial cancers such as breast cancer\, the usual orderly arrangement of cells that surround a central lumen becomes disrupted. This loss of tissue architecture can facilitate invasive migration of cells into the surrounding microenvironment and subsequent cancer metastasis. I will present our recent work which shows that an imbalance in cellular mechanical force causes tissue lumens to collapse due to mechanical instabilities. This collapse is followed by an extraordinary inside-out eversion that drives collective migration of clusters of cells through the 3D extracellular matrix (ECM). I will discuss how individual migrating cancer cells negotiate the confining spaces in tissue with a focus on the limiting role of the nucleus in confinement. I will conclude with an exploration of how alterations to the mechanical properties of the ECM in tumors might impose a selection pressure on genetically variable tumor cell populations resulting in more malignant cell phenotypes. \nAbout the Speaker: Tanmay Lele is a Professor of Biomedical Engineering and Chemical Engineering at Texas A&M University. He obtained his Ph.D. in Chemical Engineering from Purdue University followed by postdoctoral research in Vascular Biology at Harvard Medical School/Children’s Hospital. He obtained his B. Chem. Eng. degree from UDCT\, Mumbai. \nHis research focuses on understanding the mechanisms underlying the loss of cancer tissue structure and aberrant tumor mechanobiology. Over the years\, his research group has made significant contributions to the field including a recent paper that reports the first dynamic observations of acinar eversion caused by a mechanical destabilization. His group combines molecular biology and cell biology techniques with computational modeling to investigate cancer mechanobiology comprehensively. He is a fellow of the Biomedical Engineering Society and the American Institute of Medical and Biological Engineering.
URL:https://be.iisc.ac.in/event/be-dbg-seminar-titled-loss-of-tissue-structure-in-cancer-a-mechanobiological-perspective-by-prof-tanmay-lele/
LOCATION:DBG Seminar Hall\, 1st Floor\, Biological Science Building
CATEGORIES:Seminar
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BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20240812T160000
DTEND;TZID=Asia/Kolkata:20240812T170000
DTSTAMP:20260412T200609
CREATED:20240807T104007Z
LAST-MODIFIED:20240807T104033Z
UID:4395000-1723478400-1723482000@be.iisc.ac.in
SUMMARY:BE Seminar: Quantifying Cell-State Densities in Single-Cell Phenotypic Landscapes by Dr. Manu Setty
DESCRIPTION:Speaker: Dr. Manu Setty \nAssistant Professor \nFred Hutch Cancer Centre\, Seattle\, USA. \n  \nTitle: Quantifying Cell-State Densities in Single-Cell Phenotypic Landscapes \nAbstract: Single-cell studies have clearly established the continuous nature of cell-state transitions in trajectories of differentiation and disease. Moreover\, fundamental processes such as proliferation and apoptosis generate a non-uniform distribution of states within these continuous landscapes. Thus\, modeling of trajectories using single-cell data necessitates not only a continuous representation but one that accounts for variability in cell-state density. In addition to being reflective of the underlying biology\, continuous representations also enable the utilization of well-developed frameworks in multivariate statistics and dynamical systems to model and interpret large-scale single-cell data. In this seminar\, I will describe our recent algorithm\, Mellon\, that provides a fully continuous representation of high-dimensional single-cell landscapes. Mellon infers a continuous density function that can be employed to infer cell-state density at both observed cell-states represented by individual cells and potential unobserved cell-states. I will present how Mellon can help dissect the density landscape of differentiating systems\, revealing a consistent pattern of high-density regions corresponding to major cell types intertwined with low-density\, rare transitory states. Our work provides evidence implicating enhancer priming and the activation of master regulators in the emergence of these transitory states. Finally\, I will describe our ongoing work in leveraging continuous representations for interpreting multi-condition\, multi-modal single-cell data. \nAbout The Speaker: Manu Setty is an Assistant Professor at Fred Hutch Cancer Center in the Basic Sciences Division. Manu received his PhD from the Weill Cornell Graduate School in the lab of Christina Leslie where he developed machine learning algorithms for regulatory network inference and received the Frank Lappin Horsfall Fellowship award for his thesis. He then undertook a post-doctoral fellowship in the lab of Dana Pe’er where he developed trajectory detection algorithms using single-cell data and demonstrated the continuous nature of cell-fate choices during differentiation. He was recognized with the Tri-I Breakout Prize for his work at MSK. He now heads a lab that develops computational methods using single-cell and spatial data to model and interpret biological trajectories. \n 
URL:https://be.iisc.ac.in/event/be-seminar-quantifying-cell-state-densities-in-single-cell-phenotypic-landscapes-by-dr-manu-setty/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20240814T160000
DTEND;TZID=Asia/Kolkata:20240814T173000
DTSTAMP:20260412T200609
CREATED:20240813T064754Z
LAST-MODIFIED:20240813T064810Z
UID:4395083-1723651200-1723656600@be.iisc.ac.in
SUMMARY:Prof. Rinti Banerjee Memorial Lecture by Prof. Uma K Maheshwari
DESCRIPTION:
URL:https://be.iisc.ac.in/event/prof-rinti-banerjee-memorial-lecture-by-prof-uma-k-maheshwari/
LOCATION:Faculty Hall
CATEGORIES:Seminar
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