BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Department of Bioengineering - ECPv5.14.0.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Department of Bioengineering
X-ORIGINAL-URL:https://be.iisc.ac.in
X-WR-CALDESC:Events for Department of Bioengineering
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Kolkata
BEGIN:STANDARD
TZOFFSETFROM:+0530
TZOFFSETTO:+0530
TZNAME:IST
DTSTART:20240101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20241119T113000
DTEND;TZID=Asia/Kolkata:20241119T123000
DTSTAMP:20260416T174419
CREATED:20241111T052411Z
LAST-MODIFIED:20241111T052435Z
UID:4395184-1732015800-1732019400@be.iisc.ac.in
SUMMARY:BE Seminar: Nanomedicine and Genome Editing Approaches for Disease Therapies
DESCRIPTION:Speaker: Dr. Gang Bao\nDepartment of Bioengineering\, Rice University \nTitle: Nanomedicine and Genome Editing Approaches for Disease Therapies \nAbstract: The design and optimization of nanomedicine and genome editing – based tools and methods provide unprecedented opportunities for achieving better control of biological processes\, and drastic improvements in disease diagnosis and treatments. Recent advances include the development of multi-functional nanoparticles and CRISPR/Cas systems for biological and medical applications. \nIn this talk\, he will first present the recent work on magnetic nanoparticles in the lab\, including the synthesis and functionalization of magnetic nanocluster for treating metastatic cancer. He will then present the design and optimization of CRISPR/Cas9-based genome editing for treating sickle cell disease. The challenges and opportunities in developing in vivo genome editing will also be discussed. \nAbout The Speaker: Dr. Gang Bao is the Foyt Family Professor in the Department of Bioengineering at Rice University. He is also a CPRIT Senior Scholar in Cancer Research and the Director of the Cancer Bioengineering Collaborative at Rice University. Dr. Bao received his undergraduate and Master’s degrees from Shandong University in China\, and his PhD degree from Lehigh University in the US. Dr. Bao is a Fellow of the American Association of Advancement in Science (AAAS)\, American Institute for Medical and Biological Engineering (AIMBE)\, Biomedical Engineering Society (BMES)\, American Society of Mechanical Engineers (ASME)\, American Physical Society (APS)\, and International Academy of Medical and Biological Engineers (IAMBE).\nDr. Bao’s current research is focused on the development of genome editing and nanomedicine tools and approaches for biological and disease studies\, including magnetic nanoparticle-based diagnosis and treatment of chronic diseases such as cancer\, viral and non-viral based in vivo delivery methods\, design and optimization of CRISPR/Cas9 for gene editing\, and the application of gene editing for treating sickle cell disease and cystic fibrosis. \n 
URL:https://be.iisc.ac.in/event/be-seminar-nanomedicine-and-genome-editing-approaches-for-disease-therapies/
LOCATION:IDR Building – G12: Classroom 3
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Kolkata:20241121T110000
DTEND;TZID=Asia/Kolkata:20241121T120000
DTSTAMP:20260416T174419
CREATED:20241113T043559Z
LAST-MODIFIED:20241113T043559Z
UID:4395191-1732186800-1732190400@be.iisc.ac.in
SUMMARY:BE Seminar: The influence of chemo-mechanical cues from the cell environment on the chromatin organization
DESCRIPTION:Speaker: Dr. Aayush Kant\nPostdoctoral Researcher at the University of Pennsylvania\, Philadelphia \nTitle: The influence of chemo-mechanical cues from the cell environment on the chromatin organization \nAbstract: Cells continuously experience a range of physical and chemical stimuli from their environment shaping their behavior and identity\, a process that is particularly evident in diseases such as cancer. As tumor cells interact with an evolving extracellular matrix or metastasizing cells squeeze through the blood vessels during intravasation\, these stimuli trigger immediate cellular response and drive long-term phenotypic changes in the cell identity. A key mechanism underscoring these changes in cell behavior is the dynamic reorganization of chromatin – the macromolecular complex of DNA and associated proteins within the nucleus – regulating gene expression. In this talk\, I will present our recent advancements in developing a mesoscale mathematical model that captures the spatiotemporal chromatin reorganization in response to environmental cues – both chemical\, such as epigenetic dysregulation\, and physical\, in the form of osmotic shocks or mechanical deformation. This model demonstrates the experimentally observed emergent segregation of chromatin into euchromatin\, with expressed genes\, and tightly compacted silenced heterochromatin\, which often associates with the nuclear lamina. I will discuss how environment-driven kinetics of histone modifications\, such as methylation and acetylation\, affect the spatial chromatin distribution and the overall nuclear stiffness. I will also demonstrate how physical forces can directly alter chromatin compaction\, determining gene accessibility. Our theoretical predictions are validated by experimental observations obtained via high-resolution imaging and genomic sequencing techniques. The model\, grounded on agnostic thermodynamic principles\, offers insights into several disease progressions\, including metastatic cancer\, non-alcoholic fatty liver disease\, and tendinosis. Our model establishes a novel framework for mechanistically understanding the evolution of cell phenotypic identity in the context of disease mechanisms\, which is helpful in identifying therapeutic interventions. \nAbout the Speaker: Dr. Aayush Kant is a Postdoctoral Researcher at the University of Pennsylvania (Philadelphia) specializing in the study of physical forces within cells and organelles and their impact on cellular function. His research interests lie in developing a mechanistic understanding of biological systems using fundamental continuum-scale physical principles along with analytical and numerical methods. He is currently investigating how physical and chemical signals from the cell and the cell surroundings help reorganize the genome. This work utilizes mathematical modeling techniques rooted in non-equilibrium thermodynamics\, variational principles and phase-field modeling. Aayush received his Ph.D. in 2019 through a joint program between the Indian Institute of Technology Bombay (Mumbai) and Monash University (Clayton\, Australia)\, where he explored the mechanistic principles underlying the long-term pathophysiology following a traumatic brain injury. This work exemplifies yet another chemical-degradation coupled force-transduction system\, a theme that Aayush is quite keen to further explore.
URL:https://be.iisc.ac.in/event/be-seminar-the-influence-of-chemo-mechanical-cues-from-the-cell-environment-on-the-chromatin-organization/
LOCATION:CES Seminar Hall\, CES Seminar Hall\, 3rd Floor\, Biological Science Building
CATEGORIES:Seminar
END:VEVENT
END:VCALENDAR