Poster designed by Atchuta Srinivas Duddu


Registration is closed

The Centre for BioSystems Science and Engineering (BSSE) at the Indian Institute of Science (IISc), Bangalore, India has brought together biologists, engineering, and those who are trained as bioengineers while also extending its reach to medical doctors, agricultural scientists, and biomedical industries to train the next generation of leaders in the field. BSSE currently hosts six permanent faculty, ten associate faculty, one INSPIRE fellow and forty-two PhD students. Our faculty have expertise in a range of disciplines and conduct groundbreaking research providing students with a myriad of opportunities.

The BSSE Research Symposium is an annual event with a goal to increase collaboration and allow the exchange of new ideas between students, researchers, industry partners and clinical practitioners. The 8th BSSE Annual Research Symposium will be a two-day virtual event on the 28th and 29th of January, 2022. The two-day symposium will aim to have engaging scientific discussions with the themed sessions systems biology, cell biology, biomaterials and drug delivery, and health and medicine to highlight the multifaceted nature of interdisciplinary research performed in BSSE in an intuitive and interactive virtual environment. We will end the symposium with an exciting and unique panel discussion on "Biomedical Enterpreneurship: Opportunities and Challenges". We anticipate an excellent and diverse program of events and opportunities to connect with fellow peers and continuing the legacy of BSSE symposia, even while in an online format. Please share this announcement with colleagues and students who may be interested.

Sci-Comm Competition
To encourage scientific commincation, we are organizing an online competition that requires participants to record a video (3-5 min) of themselves talking about their research/project work in a way that is understandable and thought-provoking to a non-technical general audience. This video then needs to be uploaded on YouTube as a private unlisted video and shared with us. Further details are in the . Registration for the event is now closed. If you have any queries, drop a mail to us at bssesymposium2022@iisc.ac.in

We look forward to meeting you all!

Speakers


Prof. Michael Elowitz
California Institute of Technology, USA

Prof. Babis Hatzikirou
Khalifa University, UAE

Prof. Naama Brenner
Technion - Israel Institute of Technology, Israel

Prof. Abhijit Majumder
Indian Institute of Technology Bombay, India

Prof. Yamuna Krishnan
University of Chicago, USA

Prof. Greeshma Thrivikraman
Indian Institute of Technology Madras, India

Prof. Roop Mallik
Indian Institute of Technology Bombay, India

Dr Vishal Rao U.S.
HealthCare Global, Bangalore, India

Prof. Tavpritesh Sethi
Indraprastha Institute of Information Technology, Delhi, India


Panel discussion


Dr. Praapti Jayaswal
Co-Founder & CEO at AarogyaAI

Ms. Rashie Jain
Co-Founder & CEO at Onco.com

Prof. Rahul Purwar
Indian Institute of Technology Bombay; Founder and Chairman at ImmunoAct

Mr. Atharva Karulkar
Indian Institute of Technology Bombay; Co-Founder & Head-scientific programs at ImmunoAct

Prof. Aravind Kumar Rengan
Indian Institute of Technology, Hyderabad; Innovator and Mentor at CFHE, IITH

Prof. K V Venkatesh
Indian Institute of Technology Bombay; Founder and Director at MetFlux Research


Schedule

Day 1
Sessions Time (IST) Speaker
Introduction and Inauguration 9:30-9:55 Inaugural function: Addressed by Dean of Interdisciplinary Sciences Prof. Navakanta Bhat and BSSE chair Prof. Narendra Dixit
Sanjay Kumar Biswas Memorial Lecture 9:55-11:00 Prof. Michael Elowitz
Title : Circuit designs for multicellular systems, natural and synthetic
Cell-cell communication, cell fate control, memory, and other functions necessary for multicellular life are encoded by molecular circuits of interacting genes and proteins. Understanding the sometimes perplexing designs of these circuits could allow us to control cells more precisely and to program new cellular behaviors. My lab uses quantitive synthetic biology approaches to identify circuit design principles in mammalian cells, “building to understand.” In this talk, I will describe a synthetic, naturally inspired, cell fate control system that establishes multiple stable states, synthetic circuits that allow cells to control their own population sizes using a “private” communication channels, and the ability of promiscuous ligand-receptor interactions to enable specificity in cell-cell communication. These circuits embody unexpected, but sometimes elegant, circuit design principles that can enable multicellularity, both natural and synthetic.
Session 1: Systems Biology 11:00-11:40 Prof. Babis Hatzikirou
Title : EImproving tumour predictions: a Bayesian combination of dynamic modelling and machine learning approach
In clinical practice, a plethora of medical examinations are conducted to assess the state of a patient’s pathology producing a variety of clinical data. However, exploiting these data faces the following challenges: (C1) we lack the knowledge of the mechanisms involved in regulating these data variables, and (C2) data collection is sparse in time since it relies on patient’s clinical presentation. (C1) implies that only a small subset of the relevant variables can be modeled by virtue of mathematical modeling. This limitation allows models to be effective in analyzing the qualitative dynamics of the system, but limits their predictive accuracy. On the other hand, statistical learning methods are well-suited for quantitative reproduction of data, but they do not provide mechanistic understanding of the investigated problem. Moreover, due to (C2) any algorithm is challenged in learning the corresponding disease dynamics. Herein, we propose a method, based on the Bayesian coupling of mathematical modeling and machine learning (BaM3), aiming at improving individualized predictions by addressing the aforementioned challenges. As a proof of concept, we evaluate the proposed method on a synthetic dataset for brain tumor growth and analyze its performance in predicting two major clinical outputs, namely tumor burden and infiltration. The BaM3 method results in improved predictions in almost all simulated patients, especially for those with a late clinical presentation. In addition, we test the proposed methodology in two settings dealing with real patient cohorts. In both cases, namely cancer growth in chronic lymphocytic leukemia and ovarian cancer, BaM3 predictions show good agreement with reported clinical data.
11:40-12:20 Prof. Naama Brenner
Title : Exploratory learning outside the brain
Learning entails self-modification of a system under closed-loop dynamics with its environment. Not only the system's components may change, but also the way they interact with one another - like synapses during learning in the brain, that modify interactions between neurons. Such processes, however, are not limited to the brain but can be found also in other areas of biology. I will describe a framework for a primitive form of learning that takes place within the single cell. This type of learning is composed of random modifications guided by global feedback. The capacity to utilize exploratory dynamics, improvisational in nature, provide cells with the plasticity required to overcome extreme challenges and to develop novel phenotypes. Examples from cell biology and cancer progression will be presented.
12:20-12:45 Student Talk: Atchuta Srinivas Duddu
Title : Multi-stability and epigenetic influence in a mutually repressing three node network
Identifying design principles of complex regulatory processes driving cellular decision-making is essential in decoding dynamics of embryonic development, enhancing cellular reprogramming as well as designing applications in synthetic biology. A well-studied network motif is the ‘Toggle Switch (TS)’ – two mutually repressive regulators (or transcription factors), A and B. The motif enables an ‘either-or’ choice for the cell progenitor between – (A high, B low) and (A low, B high) phenotypes. Here, we investigate a network motif ‘Toggle Triad (TT)’ – three mutually repressive regulators, A, B and C. Our simulations show the TT enables co-existence of three differentiated ‘single-positive’ cell types – (A high, B low, C low), (A low, B high, C low) and (A low, B low, C high). The network further enables though in lesser frequency three ‘double-positive’ or ‘hybrid’ state - (A high, B high, C low), (A low, B high, C high) and (A high, B low, C high). Further, we have included epigenetic regulation as a phenomenological model to our framework via an epigenetic feedback parameter. We observed that the strength of epigenetic feedback as well as the duration for which it is provided play critical roles in determination of the final phenotype of the cell. Finally, we extended out understandings of the model to the cellular differentiation of naïve CD4+ T helper cells into Th1, Th2 and Th17 cells. Our results offer insights into design principles of multi-stable networks and provide framework for synthetic biology to design tristable systems.
12:45-13:10 Student Talk: Kishore Hari
Title : Coordinated expression of genes determines phenotypic landscape in EMP networks
Elucidating the principles of cellular decision-making is of fundamental importance. These decisions are often orchestrated by underlying regulatory networks. While we understand the dynamics of simple network motifs, how do large networks lead to a limited number of phenotypes, despite their complexity, remains largely elusive. Here, we investigate five different networks governing epithelial-mesenchymal plasticity and identified a latent design principles in their topology that limits their phenotypic repertoire – the presence of two “teams” of nodes engaging in a mutually inhibitory feedback loop, forming a toggle switch. These teams are specific to these networks and directly shape the phenotypic landscape and consequently the frequency and stability of terminal phenotypes vs. the intermediary ones. Our analysis reveals that network topology alone can contain information about phenotypic distributions it can lead to, thus obviating the need to simulate them. We unravel topological signatures that can drive canalization of cell-fates during diverse decision-making processes.
Lunch Break 13:10-14:30 Lunch Break
Session 2: Biomaterials and Drug Delivery 14:30-15:10 Prof. Abhijit Majumder
Title : Mechanical Microenvironment Promotes Aggressiveness in Relapsed Glioblastoma Tumor post Radiotherapy
Glioblastoma multiforme (GBM) is a malignant astrocytoma with low survival rate even when rigorous treatment regime is followed. After initial removal by surgery and radiation, the tumour almost certainly relapses within a few months and presents an aggressive phenotype. While different researchers have studied the effect of microenvironment on various tumours including GBM, the effect of mechanics on the radio-recurrent GBM tumour has never been explored. To address this question, we studied the effect of mechanical signals on the behaviour of GBM cells before and after radiation. We observed significant difference in the mechanosensing process of pre- and post-radiation population. When these cells are presented with a microenvironment matching brain stiffness, the post-radiation population showed higher migration, invasion, drug resistance, and in vivo tumorigenicity. Such differences were absent or minimal if the cells were cultured on stiffer substrates such as plastic petriplates. Further, on long duration culture on soft substrates, post-radiation cells formed tumour-like clumps in more number and at much higher rate compared to the pre-radiation cells. When the cells are retrieved from these tumoroids, cells from post-radiation tumoroids were found to be more proliferative and migratory. They also expressed higher level of N-cadherin and OCT4. Overall, this ongoing study highlights the importance of exploring the physical parameters in understanding of a biological system.
15:10-15:50 Prof Greeshma Thrivikraman
Title : Discerning the mechanism of cellular contact guidance and its implications in health & diseases
The ability of the cells to perceive and orient along aligned fibrillar topographies in the tissue microenvironment via the phenomenon of contact guidance is fundamental for tissue organization and patterning. Specifically, in certain disease conditions, like cancer, cells employ contact guidance to migrate away from the main tumor site to invade neighboring vital organs. Given its predominant role in normal physiology and disease, it is pertinent to decipher the mechanism by which the cells sense oriented fibrillar matrices in the surrounding matrix microenvironment. Hence, the first part of this talk will discuss the physical and chemical anisotropic cues that play a dominant role in contact guidance sensing by mammalian cells in a 3D fibrin gel model system. The second part of the talk will assess its involvement in tumor metastasis by utilizing melanoma cells as a model system in 3D aligned collagen matrices. The conclusions from these studies provide unique mechanistic information on contact guidance phenomenon, which can serve as the basis for designing engineered tissue constructs or to develop targeted therapies to treat invasive tumors.
15:50-16:15 Student Talk: Saswat Choudhury
Title : 4D Printing of polymers for absorbable and deployable medical devices
Most medical devices, ranging from stents to 3D scaffolds for tissue engineering still rely on the use of non-degradable materials. This necessitates a revision and/or removal surgery, either after complete healing or due to implant associated complications. Also, apart from coronary stents of Nitinol which is balloon-expandable in nature, most devices require surgery for implantation. This calls for urgent research in developing medical devices that would be both absorbable and deployable i.e., put inside the body without a surgery and can completely get absorbed inside without any revision surgery too. Now, there has been considerable work done in developing absorbable polymers of the class ‘polyesters’, namely PLA (polylactide), PCL (polycaprolactone), etc. but very little has been accomplished to make them deployable. PLA, being a shape memory polymer has been reinforced with responsive fillers to trigger its recovery via heat, magnetic field, etc, but the disadvantage is its high glass transition temperature (Tg around 70°C). We have chosen a copolymer of PLA and PTMC (poly trimethylene carbonate), called PLAMC which exhibits shape recovery at a considerably lower transition temperature of around 15-20°C. We have fabricated PLAMC via extrusion 3D printing into 3D scaffolds that can be used for bone tissue engineering. Additionally, we have reinforced PLAMC with varying proportions of iron oxide (Fe3O4) nanoparticles to enable contactless shape recovery via alternative magnetic field. In future, we envision to use these materials in making absorbable and deployable medical devices.
16:15-16:40 Student Talk: Ameya Dravid
Title : Resolvin D1-loaded nanoliposomes promote M2 polarization of macrophages and are effective in the treatment of obesity-related metabolic Osteoarthritis
Osteoarthritis (OA) is the most common joint disorder and currently affects > 300 million patients worldwide. The etiology of OA is complex but factors like obesity and joint trauma are known to contribute significantly to the pathology. Currently prescribed treatment for OA solely relies on pain management by administration of corticosteroids[1]. However, this approach is ineffective in arresting tissue damage and induces chondrotoxicity and cartilage thinning upon chronic administration[2]. Despite the drawbacks of the current treatment, there is no drug approved for human use that effectively treats OA by modifying the etiology of the disease. Unresolved inflammation significantly contributes to the OA progression by driving tissue damage, and blocking this inflammation is a viable treatment strategy. OA-associated inflammation can be resolved by the delivery of pro-resolution mediators like resolvin D1 (RvD1)[3]. However, small molecules (including RvD1) are amenable to rapid loss of activity either by efflux, lymphatic clearance, or oxidation-mediated deactivation. In this study, we increased the bioavailability of RvD1 by encapsulating it in liposomes, which served as a source for ~11 days in vitro. Such liposomes were retained intraarticularly for ~14 days in mice joints, compared to the short retention of free molecules (1-2 days). Liposomal RvD1 (Lipo-RvD1) prevented OA in healthy and obese mice models of post-traumatic OA (PTOA) at much lower doses than the reported requirement of free RvD1[3]. Since most clinical diagnoses of OA occur after the pathology has significantly progressed, good therapeutic agents are critical for the treatment. When administered in a therapeutic regimen, our formulation reversed cartilage damage in both the mice models. Finally, we show that lipo-RvD1 protects the joint by polarizing synovial macrophages preferentially towards the pro-resolution M2 phenotype over the inflammatory M1 phenotype. Lipo-RvD1, hence, shows promise as an effective agent for treating OA.
References:
1. Wei Zhang, H.O., Crispin R. Dass, Jiake Xu., Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Research, 2016. 4(15040): p. 1-14.
2. Prathap Jayaram, D.J.K., Peter Yeh, Jason Dragoo., Chondrotoxic Effects of Local Anesthetics on Human Knee Articular Cartilage: A Systematic Review. American Academy of Physical Medicine and Rehabilitation, 2019. 11(4): p. 379-400.
3. Antonia Rujia Sun, X.W., Bohao Liu, Yang Chen, Charles W. Armitage, Avinash Kollipara, Ross Crawford, Kenneth W. Beagley, Xinzhan Mao, Yin Xiao, Indira Prasadam., Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation. Scientific Reports, 2019. 9(426): p. 1-13.
Poster Session 16:40-18:00 Online poster session at https://sway.office.com/7kZJ9Lu6Sc3ld1AC
Opportunities @ BSSE 18:00-18:30 Opportunities @ BSSE
Day 2
Session 3: Cell Biology & Biomechanics 10:00-10:40 Prof. Yamuna Krishnan
Title : Next-generation targeting has organelle-level precision
Organelles are relatively autonomous sub-systems within the cell, whose activity and chemical composition reflect the cell’s metabolic state. Metabolism is altered in diseased or aging cells and this is also reflected at the level of organelles. In fact sometimes, introducing compensatory changes in organelles can restore cells to normalcy given the inherent feedback between cells and their organelles. Nature already targets the delivery of exogenous cargo with organelle-level precision in living organisms as evidenced by invading pathogens as well as endogenous signaling molecules. DNA can be self-assembled into molecularly precise, well-defined, synthetic assemblies on the nanoscale, commonly referred to as designer DNA nanodevices. Over the last decade, my lab developed a way to target DNA nanodevices to specific cells in vivo, but with organelle-level precision. Our first discovery in 2011 revealed that DNA nanodevices could reach organelles called lysosomes specific cells of live nematodes, where it functioned as a reporter of pH (1-2). Until this innovation, it was not at all obvious whether such DNA nanodevices could function inside a living cell without being interfered with, or interfering with, the cells own networks of DNA control. We spent 10 years studying the environment within lysosomes. Today I will discuss how we use the lysosome as a portal to control cell state, flip the cell “from baddie to goodie” and turn cold tumors hot in mice (3-4).
References:
1. Modi, S., et al. A DNA nanomachine that maps spatial and temporal pH changes in living cells. Nat. Nanotechnol., 2009, 4, 325-330.
2. Surana, S., et al. An autonomous DNA nanomachine maps spatiotemporal pH changes in a multicellular living organism. Nat. Commun., 2011, 2, 340.
3. Suresh, B., et. al. Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis. Proc. Natl. Acad. Sci. U.S.A. 2021, 118, e2113174118.
4. C. Cui et al A lysosome-targeted DNA nanodevice selectively targets macrophages to attenuate tumors. Nat. Nanotechnol. 2021 16, 1394-1402.
10:40-11:20 Prof. Roop Mallik
Title : Motor and Tether : Dual Role for Kinesin at Membrane Contact Sites
How the different organelles inside a living cell communicate between themselves is a subject of intense investigation. The extensively interconnected membrane of the endoplasmic reticulum (ER) may act as a common conduit for such communication because many different kinds of organelles can exchange lipids and proteins with the ER at ER-organelle membrane contact sites (MCS). A fundamental physical constraint, however, appears to have been overlooked in the extensive literature related to MCS. Most organelles are too large to diffuse around freely inside the cell. How, then, can they find their cognate MCS at distant locations on the ER membrane inside the cell? Cellular organelles are also actively transported by the kinesin and dynein motors. We therefore hypothesized that motors carrying the organelle could get switched from Transporter to Tether when the organelle reaches a specific MCS. Such a switch would allow organelles to sample the intracellular space with intermittent “pit-stops” at MCS, where they can exchange proteins/lipids with the ER for onward communication. I will discuss experimental evidence obtained by us to support this hypothesis.
11:20-11:45 Student Talk: Mitali Shah
Title : Investigation of the macrophage response to non-stimulatory phagocytosis
Nano and micro-sized particles lie at the frontier of current advancements in drug delivery and bio-imaging. Specifically for drug and gene-delivery applications, carrier nanoparticles are targeted to be taken up by cells to achieve desired therapeutic effects. This uptake generally happens via the process of phagocytosis, which is the phenomenon by which a cell engulfs a foreign object. Effective design of nanoparticle systems for enhanced drug and vaccine delivery requires a holistic understanding of the phenomenon of phagocytosis. While there is some evidence that surface modification and size-based differences of the phagocytosed object can affect their maturation inside the macrophage, the biophysical and biochemical processes that underlie these responses are not well understood. Our experiments have shown that polystyrene nanoparticles do not accumulate inside lysosomes of macrophages at the same rate or extent as bacteria do. However, upon providing signals for activation, we were able to alter the extent of maturation of particle-containing phagosomes. We aim to probe this system further to delineate the macrophage’s response to particles of different materials and sizes, and under different conditions of activation. Deciphering this response will be a crucial stepping stone in engineering efficient drug and vaccine delivery systems.
11:45-12:10 Student Talk: Harsh Kumar
Title : Bipartite pore-forming toxin YaxAB: towards understanding pore formation and cellular responses using single-molecule TIRF microscopy
Bacteria employ a variety of strategies to invade and colonize the host tissue. However, the host cell membrane serves as the first line of defence. Bacteria secrete several toxins to overcome the cellular barrier. Members of this arsenal are bacterial pore-forming toxins (PFTs) that disrupt the lipid bilayer by forming nano-sized pores. These pores permeabilize the host cell membrane to ions and small molecules, thereby increasing infection severity. As a response to PFTs, the host cell engages in membrane repair mechanisms to overcome the damage inflicted, and to maintain cellular homeostasis. This work aims to elucidate the pore-forming mechanism of the bipartite PFT YaxAB, produced by Yersinia enterocolitica, a human pathogen causing fever, diarrhoea, and sepsis in some instances. Fluorescently tagged versions of YaxAB subunits will enable us to study the self-assembly of toxin on the host cellular membrane using single-molecule TIRF microscopy. HeLa cells responded to YaxAB by the formation of surface blebs, which retracted over time, suggesting a protective role employed by the cell. Our study will help in understanding the pore formation mechanism of functionally diverse subunits of a PFT and the ability of the host to tackle them.
12:10-12:35 Student Talk: Neha Paddillaya
Title : Cell-substrate interactions in mechano-diagnostic of cancer metastasis
Cell adhesions to the underlying substrate occur via integrin clustering, and their binding to the actin cytoskeleton regulates crucial cellular processes. Oncogenes usurp anchorage-dependent mechanisms in cells during cancer metastasis, resulting in invasive behaviours. Methods to quantify the strength of cell adhesions to substrates using a fluid shear device provides a label-free and non-invasive way to characterize the cell-substrate interactions of hundreds of cells in a single experiment [1]. Methods Breast epithelial cells (MCF-7 and MDA-MB-231), lung epithelial cells (A549 and HPL1D), HeLa, and NIH3T3 cells were seeded (5000 cells/ml) on glass coverslips coated with 40µg/ml collagen-I, for 12 hours and stained with Hoechst and placed on an inverted microscope for the de-adhesion experiments. A custom fluid shear device was used, and the shear stress was ramped at 0.2 Pa/ minute, and cells were imaged to quantify the number of cells remaining on the substrate at each time point. Traction force microscopy was performed, and the traction stresses were computed on cells seeded on 10 kPa polyacrylamide gels using the Reg-FTTC method [2]. Cells were fixed and imaged to identify changes in actin and vinculin. Data from de-adhesion experiments were fit to a theoretical model based on the 50% de-adhesion strengths and the cell areas [3]. NIH3T3 fibroblasts were also used to understand the ligand-specific adhesion characteristics to fibronectin compared to collagen-1. Results Detachment responses from the substrate were sigmoidal for the different cell types in the study and included three well-defined shear stress thresholds marked in the figure. More metastatic cells, A549 and MDAMB-231, had significantly lower adhesion strengths, t50, than their less metastatic pair of cell lines such as HPL1D and MCF7. The cell de-adhesion dynamics was inversely correlated with the metastatic potential of cells. We used experimental data to test the goodness of fits from the model predictions for the different cell types in our study. MDAMB-231 and A549 cell lines had the highest values of tractions, followed by NIH3T3, HPL1D, Hela and MCF7. The vinculin staining of these cells also showed differences between highly metastatic and non-metastatic cells. The inherent differences in these adhesions to different ligand types was seen in NIH3T3 cells on fibronectin and collagen-1 coated substrates, with the adhesion strength increasing initially and then plateauing. The traction force also increased with an increased duration of exposure to shear stress. The differences in the de-adhesion strengths between fibronectin and collagen-1 groups are attributed to fibronectin induced α5β1 and αvβ3 integrin and collagen-1 induced α1β1 and α2β1 integrin. Discussion Model fits the experimentally obtained HPL1D, and MCF7 cells show the best fits to the model, which shows the importance of the projected areas in cell adhesions to substrates. These results show apparent differences in adhesion strengths and cell invasiveness potentials that may be useful in diagnostics and investigations that target the cell adhesome in diseases like cancers and other pathologies.
References
[1] Paddillaya, N, et al., 2019.
[2] Kulkarni, A.H, et al., 2018.
[3] Maan, R, et al., 2018.
Lunch Break 12:35-13:30 Lunch Break
Session 4: Health and Medicine 13:30-14:10 Prof Tavpritesh Sethi
Title : Building Pandemic Preparedness with Agile Data and Machine Learning
In this talk, I will discuss or work on challenges and finding solutions for building pandemic preparedness. The talk will showcase the approaches for triangulating insights from diverse sources of data and engineering live solutions. Examples will include our work on genomic surveillance of strains using machine learning, resource allocation using reinforcement learning, and effective information systems using natural language understanding.
14:10-14:50 Dr. Vishal Rao U.S.
Title : Bridging the gap between biological advances and technological advances: A journey from possibility to actuality
This talk discusses the approaches which will pave a fresh path to debunking old theories, disrupting the status quo, and reimagining evidence-based medicine soaring on the wings of technological advancements. In today’s era of evidence-based medicine, translational medicine is playing a pivotal role in taking innovation from bench to bedside medicine. Traditionally, the bench to bedside medicine takes more than a decade to materialize, but today, with the research-to-practice hyperloop that has been created in response to the challenges thrown in by the pandemic, the possibilities for disruptive innovation are immense. We need to adopt the Design Health thinking to holistically identify and define the problem which alone leads to a sustainable solution. This will help us decide when to do research, when to do innovations which is an improvement on the status quo, when to do inventions which makes the innovation disruptive, and when to work around the problem through a Jugaad innovation, which is a smart fix amid the cost and time constraints that deny a comprehensive ideal resolution. We must bring about an academia-industry collaboration to create an innovation ecosystem by bridging the gap between biological advances and technological advances. In this talk, I will highlight the need to connect the genomics with the proteomics and microbiomics, while also looking beyond biology to incorporate key elements of physics, chemistry and quantum physics into an integrated ecosystem of innovation.
14:50-15:15 Student Talk: Pallavi Sharma
Title : Inhalable drug-loaded microparticles for TB Treatment
Inhalable microparticle-based drug delivery platforms offer efficient deposition in lungs and improved pharmacokinetics of the encapsulated cargo. In this study, we sought to employ inhalation route for Tuberculosis (TB) treatment to improve delivery efficiency and patient compliance. Polymeric microparticles were designed to maximize internalization by Mycobacteria-infected macrophages. Cytocompatibility assay and histological analysis in vivo confirmed that the formulations were safe and did not elicit any adverse reaction. First line anti-TB drug Rifampicin was encapsulated within engineered microparticles and these exhibited improved performance in reducing intracellular bacteria. Additionally, the engineered particles demonstrated two-fold higher uptake by resident alveolar macrophages after pulmonary delivery. This study provides a framework for future design of drug carriers to improve the delivery of anti-TB drugs inside Mycobacteria-infected cells through inhalation route.
Poster Session 15:15-16:00 Online Poster session at https://sway.office.com/7kZJ9Lu6Sc3ld1AC
Panel Discussion 16:00-17:30 Biomedical Enterepreneurship : Challenges and Opportunities
Closing ceremony 17:30-18:00 Closing ceremony

Venue:The event will be streamed live on youtube. The link will be sent to registered participants..

Contact us @BSSE_Office


Links to previous symposia


7 / 14