{"id":1003,"date":"2021-10-04T11:56:14","date_gmt":"2021-10-04T11:56:14","guid":{"rendered":"https:\/\/be.iisc.ac.in\/~mkjolly\/?page_id=1003"},"modified":"2025-09-08T12:44:26","modified_gmt":"2025-09-08T07:14:26","slug":"csb-iisc","status":"publish","type":"page","link":"https:\/\/be.iisc.ac.in\/~mkjolly\/","title":{"rendered":"CSB IISc"},"content":{"rendered":"\n<div class=\"wp-block-jetpack-slideshow aligncenter\" data-autoplay=\"true\" data-delay=\"5\" data-effect=\"slide\"><div class=\"wp-block-jetpack-slideshow_container swiper-container\"><ul class=\"wp-block-jetpack-slideshow_swiper-wrapper swiper-wrapper\"><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"4000\" height=\"2250\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1027\" data-id=\"1027\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2021\/10\/CSB_focus.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2021\/10\/CSB_focus.png 4000w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2021\/10\/CSB_focus-300x169.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2021\/10\/CSB_focus-1024x576.png 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2021\/10\/CSB_focus-768x432.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2021\/10\/CSB_focus-1536x864.png 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2021\/10\/CSB_focus-2048x1152.png 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2021\/10\/CSB_focus-1568x882.png 1568w\" sizes=\"(max-width: 4000px) 100vw, 4000px\" \/><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"3999\" height=\"2250\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1215\" data-id=\"1215\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Melanoma-1.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Melanoma-1.png 3999w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Melanoma-1-300x169.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Melanoma-1-1024x576.png 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Melanoma-1-768x432.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Melanoma-1-1536x864.png 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Melanoma-1-2048x1152.png 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Melanoma-1-1568x882.png 1568w\" sizes=\"(max-width: 3999px) 100vw, 3999px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma. Pillai M, Jolly MK (2021). iScience, 24: 103111<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"2908\" height=\"2480\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1223\" data-id=\"1223\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TT-paper.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TT-paper.png 2908w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TT-paper-300x256.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TT-paper-1024x873.png 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TT-paper-768x655.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TT-paper-1536x1310.png 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TT-paper-2048x1747.png 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TT-paper-1568x1337.png 1568w\" sizes=\"(max-width: 2908px) 100vw, 2908px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Multistability in cellular differentiation enabled by a network of three mutually repressing master regulators. Duddu AS, Sahoo S, Hati S, Jhunjhunwala S, Jolly MK (2020). Journal of the Royal Society Interface, 17 (170): 20200631<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"2250\" height=\"3999\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1221\" data-id=\"1221\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TamRes.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TamRes.png 2250w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TamRes-169x300.png 169w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TamRes-576x1024.png 576w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TamRes-768x1365.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TamRes-864x1536.png 864w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TamRes-1152x2048.png 1152w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/TamRes-1568x2787.png 1568w\" sizes=\"(max-width: 2250px) 100vw, 2250px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells. Sahoo S, Mishra A, Kaur H, Hari K, Muralidharan S, Mandal S, Jolly MK (2021). NAR Cancer, 3 (3): zcab027<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"3999\" height=\"2250\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1222\" data-id=\"1222\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Teams-landscape-schematic.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Teams-landscape-schematic.png 3999w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Teams-landscape-schematic-300x169.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Teams-landscape-schematic-1024x576.png 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Teams-landscape-schematic-768x432.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Teams-landscape-schematic-1536x864.png 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Teams-landscape-schematic-2048x1152.png 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Teams-landscape-schematic-1568x882.png 1568w\" sizes=\"(max-width: 3999px) 100vw, 3999px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Landscape of epithelial mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks. Hari K, Ullanat U, Balasubramanian A, Gopalan A, Jolly MK (2022). eLife 11:e76535.<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1440\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1218\" data-id=\"1218\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Modularity-scaled.jpg\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Modularity-scaled.jpg 2560w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Modularity-300x169.jpg 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Modularity-1024x576.jpg 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Modularity-768x432.jpg 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Modularity-1536x864.jpg 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Modularity-2048x1152.jpg 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Modularity-1568x882.jpg 1568w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Functional resilience of mutually repressing motifs embedded in larger regulatory networks Harlapur P,  Duddu AS, Hari K, Jolly MK (2021) bioRxiv:475824<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"3999\" height=\"2250\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1217\" data-id=\"1217\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Mexican-Standoff.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Mexican-Standoff.png 3999w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Mexican-Standoff-300x169.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Mexican-Standoff-1024x576.png 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Mexican-Standoff-768x432.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Mexican-Standoff-1536x864.png 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Mexican-Standoff-2048x1152.png 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Mexican-Standoff-1568x882.png 1568w\" sizes=\"(max-width: 3999px) 100vw, 3999px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity during helper T-cell differentiation. Duddu AS, Jhunjhunwala S, Jolly MK (2021). Mol Biol Cell 33(6):ar46.<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"3600\" height=\"2400\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1214\" data-id=\"1214\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3.png 3600w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3-300x200.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3-1024x683.png 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3-768x512.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3-1536x1024.png 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3-2048x1365.png 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3-1568x1045.png 1568w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-3-272x182.png 272w\" sizes=\"(max-width: 3600px) 100vw, 3600px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Interconnected high-dimensional landscapes of epithelial-mesenchymal plasticity and stemness. Sahoo S, Ashraf B, Duddu AS, Biddle A, Jolly MK (2022). Clin Exp Metastasis 39(2):279-290<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"3999\" height=\"2250\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1213\" data-id=\"1213\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-2.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-2.png 3999w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-2-300x169.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-2-1024x576.png 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-2-768x432.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-2-1536x864.png 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-2-2048x1152.png 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-2-1568x882.png 1568w\" sizes=\"(max-width: 3999px) 100vw, 3999px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Interconnected high-dimensional landscapes of epithelial-mesenchymal plasticity and stemness. Sahoo S, Ashraf B, Duddu AS, Biddle A, Jolly MK (2022). Clin Exp Metastasis 39(2):279-290<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"2550\" height=\"3900\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1212\" data-id=\"1212\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-1.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-1.png 2550w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-1-196x300.png 196w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-1-670x1024.png 670w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-1-768x1175.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-1-1004x1536.png 1004w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-1-1339x2048.png 1339w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/EMTree-review-1-1568x2398.png 1568w\" sizes=\"(max-width: 2550px) 100vw, 2550px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Interconnected high-dimensional landscapes of epithelial-mesenchymal plasticity and stemness. Sahoo S, Ashraf B, Duddu AS, Biddle A, Jolly MK (2022).  Clin Exp Metastasis 39(2):279-290<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"2069\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1220\" data-id=\"1220\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Seismic-waddingtons-landscape-scaled.jpg\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Seismic-waddingtons-landscape-scaled.jpg 2560w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Seismic-waddingtons-landscape-300x242.jpg 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Seismic-waddingtons-landscape-1024x828.jpg 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Seismic-waddingtons-landscape-768x621.jpg 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Seismic-waddingtons-landscape-1536x1241.jpg 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Seismic-waddingtons-landscape-2048x1655.jpg 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/Seismic-waddingtons-landscape-1568x1267.jpg 1568w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Cancer: more than a geneticist\u2019s Pandora\u2019s box. Saxena K, Subbalakshmi AR, Kulkarni P, Jolly MK (2022). J Biosci 47, 21 (2022)<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1384\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1243\" data-id=\"1243\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/gradient_2d-scaled.jpg\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/gradient_2d-scaled.jpg 2560w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/gradient_2d-300x162.jpg 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/gradient_2d-1024x554.jpg 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/gradient_2d-768x415.jpg 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/gradient_2d-1536x830.jpg 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/gradient_2d-2048x1107.jpg 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/gradient_2d-1568x848.jpg 1568w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Emergence of planar cell polarity from the interplay of asymmetric interaction and tissue-level gradients. Singh D, Jolly MK, Rizvi MS (2021). bioRxiv: 468750<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"951\" height=\"317\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1168\" data-id=\"1168\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/02\/Slide2.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/02\/Slide2.png 951w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/02\/Slide2-300x100.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/02\/Slide2-768x256.png 768w\" sizes=\"(max-width: 951px) 100vw, 951px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Book Chapters and Journal Cover Page<\/figcaption><\/figure><\/li><li class=\"wp-block-jetpack-slideshow_slide swiper-slide\"><figure><img loading=\"lazy\" decoding=\"async\" width=\"2100\" height=\"1500\" alt=\"\" class=\"wp-block-jetpack-slideshow_image wp-image-1225\" data-id=\"1225\" src=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/waddington-landscape-of-cell-differentiation.png\" srcset=\"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/waddington-landscape-of-cell-differentiation.png 2100w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/waddington-landscape-of-cell-differentiation-300x214.png 300w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/waddington-landscape-of-cell-differentiation-1024x731.png 1024w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/waddington-landscape-of-cell-differentiation-768x549.png 768w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/waddington-landscape-of-cell-differentiation-1536x1097.png 1536w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/waddington-landscape-of-cell-differentiation-2048x1463.png 2048w, https:\/\/be.iisc.ac.in\/~mkjolly\/wp-content\/uploads\/2022\/03\/waddington-landscape-of-cell-differentiation-1568x1120.png 1568w\" sizes=\"(max-width: 2100px) 100vw, 2100px\" \/><figcaption class=\"wp-block-jetpack-slideshow_caption gallery-caption\">Emergent properties of the HNF4\u03b1-PPAR\u03b3 network may drive consequent phenotypic plasticity in NAFLD. Sahoo S Singh D, Chakraborty P, Jolly MK (2020). Journal of Clinical Medicine, 9 (3): 870<\/figcaption><\/figure><\/li><\/ul><a class=\"wp-block-jetpack-slideshow_button-prev swiper-button-prev swiper-button-white\" role=\"button\"><\/a><a class=\"wp-block-jetpack-slideshow_button-next swiper-button-next swiper-button-white\" role=\"button\"><\/a><a aria-label=\"Pause Slideshow\" class=\"wp-block-jetpack-slideshow_button-pause\" role=\"button\"><\/a><div class=\"wp-block-jetpack-slideshow_pagination swiper-pagination swiper-pagination-white\"><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-columns wider is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p>Cancer metastasis and therapy resistance remain unsolved clinical challenges and cause almost all fatalities due to cancer. Our long-term goal is to design more effective therapeutic strategies that can prevent metastasis and therapy resistance, using a network-level and dynamic understanding of the molecular mechanisms gained through an interdisciplinary systems biology approach.<\/p>\n\n\n\n<p>Our <a href=\"https:\/\/be.iisc.ac.in\/~mkjolly\/?page_id=68\">research interests<\/a> are at&nbsp;the intersection of cancer biology and computational systems biology. Working closely with experimental collaborators, we develop predictive mechanism-based multi-scale mathematical models to elucidate the emergent&nbsp;dynamics of cellular networks&nbsp;driving metastasis and drug resistance.<\/p>\n\n\n\n<p>Interested in joining the lab? <a href=\"https:\/\/be.iisc.ac.in\/~mkjolly\/contact\/\">Contact us<\/a>.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<p class=\"has-text-align-center has-large-font-size\"><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<ul class=\"wp-block-social-links is-style-default is-layout-flex wp-block-social-links-is-layout-flex\"><\/ul>\n<\/div>\n<\/div>\n\n\n        <div>\r\n            <a class=\"twitter-timeline\" data-width=\"\" data-lang=\"\"\r\n                data-chrome=\"\" data-height=\"400\"\r\n                data-theme=\"light\" href=\"https:\/\/twitter.com\/mkjolly15\"\r\n                rel=\u201dnofollow\u201d>\r\n                 mkjolly15            <\/a>\r\n\r\n            <\/div> \r\n        \n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cancer metastasis and therapy resistance remain unsolved clinical challenges and cause almost all fatalities due to cancer. Our long-term goal is to design more effective therapeutic strategies that can prevent metastasis and therapy resistance, using a network-level and dynamic understanding of the molecular mechanisms gained through an interdisciplinary systems biology approach. Our research interests are<a class=\"more-link\" href=\"https:\/\/be.iisc.ac.in\/~mkjolly\/\">Continue reading <span class=\"screen-reader-text\">&#8220;CSB IISc&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-1003","page","type-page","status-publish","hentry","entry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/pages\/1003","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/comments?post=1003"}],"version-history":[{"count":37,"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/pages\/1003\/revisions"}],"predecessor-version":[{"id":2347,"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/pages\/1003\/revisions\/2347"}],"wp:attachment":[{"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/media?parent=1003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}