{"id":60,"date":"2020-09-25T17:23:59","date_gmt":"2020-09-25T17:23:59","guid":{"rendered":"https:\/\/be.iisc.ac.in\/~mkjolly\/?page_id=60"},"modified":"2025-12-28T23:04:51","modified_gmt":"2025-12-28T17:34:51","slug":"publications","status":"publish","type":"page","link":"https:\/\/be.iisc.ac.in\/~mkjolly\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

For the latest updates, please visit Google Scholar (Total citations: 14,000+; h-index= 65)<\/a><\/p>\n\n\n\n

*Equal contribution, #<\/sup>Corresponding author; Members from the group are underlined<\/p>\n\n\n\n

Peer-Reviewed Articles<\/strong><\/h5>\n\n\n\n
2026<\/a> | 2025<\/a> | 2024<\/a> | 2023<\/a> | 2022<\/a> | 2021<\/a> | 2020<\/a> | Pre – 2019<\/a><\/h5>\n\n\n\n
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2026<\/span><\/h4>\n\n\n\n

Repurposing statins in combination therapy for effective ablation of metastatic breast cancer.<\/strong>
Aara R, Borker NS, Sajimon J, Subhadarshini S<\/span>, Snijesh VP, Nimbalkar VP, Moorthy M, Thankamony AP, Krishnan RA, Aich D, Das D, Jolly MK<\/strong>, Prabhu JS, Nair R (2026). Advances in Cancer Biology \u2013 Metastasis, <\/em>16: 100166<\/a><\/p>\n<\/div><\/div>\n\n\n\n

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2025<\/span><\/h4>\n\n\n\n

A multilevel formalism to model the hybrid E\/M phenotypes in epithelial-mesenchymal plasticity.<\/strong>
Hari K<\/span>, Tripathi S, Anand V<\/span>, Jolly MK<\/strong>, Levine H (2025). Biophysical Journal, in press<\/a><\/em><\/p>\n\n\n\n

Bioenergetic reprogramming of macrophagses reduces drug tolerance in Mycobacterium tuberculosis.<\/strong>
Yadav V, Sahoo S<\/span>, Malhotra N, Mishra R, Sreedharan S, Rajmani RS, Shanmugam S, Shandil RK, Narayanan S, Thacker VV, Laxman S, Jolly MK<\/strong>, Seshasayee ASN, Singh A. Nature Communications<\/em>, 16: 9370<\/a><\/p>\n\n\n\n

Fractal measures as predictors of histopathological complexity in breast carcinoma mammograms.<\/strong>
Das A#<\/sup>, Bhat R#<\/sup>, Jolly MK<\/strong>#<\/sup> (2025). Physical Biology, <\/em>22: 066006<\/a><\/p>\n\n\n\n

Mutually inhibiting teams of nodes: a predictive framework for structure-dynamics relationships in gene regulatory networks.<\/strong>
Shyam S, Nandan N, Anand V<\/span>, Jolly MK<\/strong>#<\/sup>, Hari K#<\/sup> <\/em>(2025).<\/em> Physical Biology, <\/em>22: 066008<\/a><\/p>\n\n\n\n

GRiNS: A python library for simulating gene regulatory networks.<\/strong>
Harlapur P, Harshavardhan BV<\/span>, Jolly MK<\/strong> (2025). BMC Bioinformatics, <\/em>26: 250<\/a><\/p>\n\n\n\n

Low-GPX4 sustained drug-tolerant persister state in TNBC by a targetable adaptive FSP1 upregulation.<\/strong>
Chaudhury N, Mandal D, Choudhary BS, Patra S, Jain D, Poonia P, Shaikh S, Tekalkar S, Malvankar S, Shivashankar A, Jog E, Pilankar L, Thorat R, Kailje VV, Khanna S, Manna S, Khan BK, Jadhav A, Sharma K, Ramu S, Sahoo S<\/span>, Jolly MK<\/strong>, Dalal SN, Sinha S, Nair NU, Ruppin E, Lamballe F, Maina F, Verma N (2025). Redox Biology, <\/em>87: 103864<\/a><\/p>\n\n\n\n

HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation.<\/strong>
Ashray N, Suresh S, Bhide A, Shyamal S, Pranya N, Mishra A, Patil S, Anuradha A, Hansda S, Harshavardhan BV<\/span>, Jolly MK<\/strong>, Modi D (2025). Cell Death Disease, <\/em>11: 516<\/a><\/p>\n\n\n\n

An integrative molecular systems approach unravels mechanisms underlying biphasic nitrate uptake by plant nitrate transporter NRT1.1.<\/strong>
Subhadarshini S, Sahoo S<\/span>, Jolly MK<\/strong>, Rashid M (2025). NPJ Systems Biology & Applications, <\/em>11: 112<\/a><\/p>\n\n\n\n

Oxidized dextran and thiolated chitosan-based hydrogel driven biomimetic triple negative breast cancer 3D in vitro model for cancer progression and therapeutic studies.<\/strong>
Modi U, Makwana P, Dhimmar U, Ramu S<\/span>, Jolly MK<\/strong>, Vasita R (2025). Journal of Materials Chemistry B, <\/em>13: 13972-13991<\/a><\/p>\n\n\n\n

Impacts of competition and phenotypic plasticity on the viability of adaptive therapy.<\/strong>
Vibishan B, Jain P, Sharma V, Hari K<\/span>, Kadelka C, George JT#<\/sup>, Jolly MK<\/strong>#<\/sup> (2025). Mathematical Biosciences, <\/em>389: 109522<\/a><\/p>\n\n\n\n

Role of intratumoral heterogeneity in metastatic progression and drug resistance.<\/strong>
Borker NS, Sajimon J, Subhadarshini S<\/span>, Aara R, Jolly MK<\/strong>, Prabhu JS, Nair R (2025). Discover Oncology<\/em>, 16: 1689<\/a><\/p>\n\n\n\n

Balancing the cellular budget: lessons in metabolism from microbes to cancer.<\/strong>
Vibishan B<\/span>, Jolly MK<\/strong>#<\/sup>, Goyal A#<\/sup> (2025). Biosystems, <\/em>256: 105571<\/a><\/p>\n\n\n\n

Emergent dynamics of cellular decision making in multi-node mutually repressive regulatory networks.<\/strong>
Harshavardhan BV, Billakurthi HS<\/span>, Adigwe S, Hari K<\/span>, Levine H, Gedeon T#<\/sup>,\u00a0Jolly MK#<\/sup><\/strong> (2025). Journal of the Royal Society Interface,\u00a0<\/em>22:\u00a020250190<\/a><\/p>\n\n\n\n

Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients.<\/strong>
Mitra P, Saha U, Stephen JK, Prasad P, Patel AK, Harshavardhan BV<\/span>, Mondal SK, Kurkalang S, Roy S, Ghosh A, Roy SS, Sarma JD, Biswas NK, Acharya M, Sharan R, Arun P, Jolly MK<\/strong>, Maitra A, Singh S (2025). Journal of Experimental and Clinical Cancer Research, <\/em>44: 142<\/a><\/p>\n\n\n\n

Exploring the role of EMT in ovarian cancer progression: insights from a multiscale mathematical model.<\/strong>
Oliver S, Williams M, Jolly MK<\/strong>, Gonazlez D, Powathil G (2025). NPJ Systems Biology & Applications, <\/em>11: 36<\/a><\/p>\n\n\n\n

Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients. <\/strong>
Mitra P, Saha U, Stephen JK, Prasad P, Patel AK, Harshavardhan BV, Mondal SK, Kurkalang S, Roy S, Ghosh A, Roy SS, Sarma JD, Biswas NK, Acharya M, Sharan R, Arun P, Jolly MK<\/strong>, Maitra A, Singh S (2025). Journal of Experimental and Clinical Cancer Research, 44: 142<\/em><\/a><\/p>\n\n\n\n

Exploring the role of EMT in ovarian cancer progression: insights from a multiscale mathematical model.<\/strong>
Oliver S, Williams M, Jolly MK<\/strong>, Gonazlez D, Powathil G (2025). NPJ Systems Biology & Applications, 11: 36<\/em><\/a><\/p>\n\n\n\n

An integrative phenotype-structured partial differential equation model for the population dynamics of epithelial-mesenchymal transition.<\/strong>
Guilberteau J*, Jain P*, Jolly MK#<\/sup><\/strong>, Pouchol P#<\/sup>, Duteil NP#<\/sup> (2025). NPJ Systems Biology & Applications, 11: 24<\/em><\/a><\/p>\n\n\n\n

EGFR-to-Src family tyrosine kinase switching in proliferating-DTP TNBC cells creates a hyperphosphorylation-dependent vulnerability to EGFR TKI.<\/strong>
Chaudhary N, Choudhary BS, Shivashankar A, Manna S, Ved K, Shaikh S, Khanna S, Barr J, Dani J, Sahoo S, Soundharya R<\/span>, Jolly MK<\/strong>, Verma N (2025). Cancer Cell International, 25: 55<\/a><\/em><\/p>\n\n\n\n

DNA walk of specific fused oncogenes exhibit distinct fractal geometric characteristics in nucleotide patterns. 
<\/strong>Das A, Sehgal M, Singh A, Goyal R, Prabhakar M<\/span>, Fricke J, Mambetsariev I, Kulkarni P, Jolly MK<\/strong>, Salgia R (2025). Physica A, 662: 130437<\/a><\/em><\/p>\n\n\n\n

Design principles of regulatory networks underlying epithelial-mesenchymal plasticity in cancer cells. <\/strong>
Sahoo S,<\/span> Hari K<\/span>, Jolly MK#<\/sup><\/strong> (2025) Current Opinion in Cell Biology, 92: 102445<\/a><\/em><\/p>\n\n\n\n

Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks. <\/strong>
Hari K*,<\/span> Harlapur P*,<\/span> Saxena A*,<\/span> Haldar K,<\/span> Girish A,<\/span> Malpani T<\/span>, Levine H#<\/sup><\/strong>, Jolly MK#<\/sup><\/strong> (2025) iScience, 28 : 111730<\/em><\/a><\/p>\n<\/div><\/div>\n\n\n\n

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2024<\/span><\/h4>\n\n\n\n

Emergence of planar cell polarity from the interplay of local interactions and global gradients. <\/strong>
Singh D<\/span>, Ramaswamy R, Jolly MK#<\/sup><\/strong>, Rizvi MS#<\/sup><\/strong> (2024) eLife, 13: e84053<\/a><\/em><\/p>\n\n\n\n

Endosomal pH is an evolutionarily conserved trait of phenotypic plasticity in colorectal cancer. <\/strong>
Prasad H, BV Harshavardhan,<\/span> Subbalakshmi AR,<\/span> Mandal S<\/span>, Jolly MK<\/strong>, Visweswariah S (2024) NPJ Systems Biology & Applications, 10: 149<\/em><\/a><\/p>\n\n\n\n

Lineage-specific dynamics of loss of X-upregulation during inactive-X reactivation<\/strong>.
Naik HC, Chandel D, Majumdar S, Arava M, Baro R, BV Harshavardhan,<\/span> Hari K<\/span>, Ayyamperumal P, Avinchal, Jolly MK<\/strong>, Gayen S (2024) Stem Cell Reports, 19 (11): 1564-82<\/em><\/a><\/p>\n\n\n\n

Multistability and predominant hybrid phenotypes in a four node mutually repressive network of Th1\/Th2\/Th17\/Treg differentiation. <\/strong>
Duddu AS<\/span>, Andreas E, BV Harshavardhan,<\/span> Grover K,<\/span> Singh VR,<\/span> Hari K<\/span>, Jhunjhunwala S#<\/sup><\/strong>, Cummins B#<\/sup><\/strong>, Gedeon T#<\/sup><\/strong>, Jolly MK#<\/sup><\/strong> (2024) NPJ Systems Biology & Applications, 10: 123<\/em><\/a><\/p>\n\n\n\n

Distinct melanocyte subpopulations defined by stochastic expression of proliferation or maturation programs enable a rapid and sustainable pigmentation response.<\/strong>
Aggarwal A, Nasreen A, Sharma B, Sahoo S<\/span>, Aswin K, Faruq M, Pandey R, Jolly MK<\/strong>, Singh A, Gokhale RS, Natarajan VT (2024) PLoS Biology, 22 (8): e3002776<\/em><\/a><\/p>\n\n\n\n

Drug tolerance and persistence in bacteria, fungi and cancer cells: role of non-genetic heterogeneity. <\/strong>
El Meouche I, Jain P<\/span>, Jolly MK<\/strong>, Capp J-P (2024) Translational Oncology, 49: 102069<\/em><\/a><\/p>\n\n\n\n

Microenvironmental entropy dynamics analysis reveals novel insights in Notch-Delta-Jagged decision-making mechanism. <\/strong>
Pujar AA<\/span>, Barua A, Dey PS,<\/span> Singh D,<\/span> Roy U<\/span>, Jolly MK<\/strong>#<\/sup>, Hatzikirou H#<\/sup> (2024) iScience, 27 (9): 110569<\/a><\/em><\/p>\n\n\n\n

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities. <\/strong>
Desai P, Takahshi N, Kumar R, Nichols S, Malin J, Hunt A, Schultz C, Cao Y, Tillo D, Nousome D, Chauhan L<\/span>, Sciuto L, Jordan K, Rajapakse V, Tandon M, Lissa D, Zhang Y, Kumar S, Pongor L, Singh A, Schroder B, Sharma AK, Chang T, Vilimas R, Pinkiert D, Graham C, Butcher D, Warner A, Sebastian R, Mahon M, Baker K, Cheng J, Berger A, Lake R, Abel M, Krishnamurthy M, Chrisafis G, Fitzergald P, Nirula M, Goyal S, Atkinson D, Bateman NW, Abulez T, Nair G, Apolo A, Guha U, Karim B, El Meskini R, Ohler ZW, Jolly MK<\/strong>, Schaffer A, Ruppin E, Kleiner D, Miettinen M, Brown TG, Hewitt S, Conrads T, Thomas A (2024) Cell Reports Medicine, 5 (6): 101610<\/em><\/a><\/p>\n\n\n\n

Reconstructing the single-cell lineages and diversity in fates during epithelial-to-mesenchymal transition. <\/strong>
Cheng Y-C, Zhang Y, Tripathi S, Harshavardhan BV<\/span>, Jolly MK<\/strong>, Schiebinger G, Levine H, McDonald T, Michor F (2024) Proceedings of the National Academy of Sciences USA (PNAS), 121 (32): e2406842121<\/em><\/a><\/p>\n\n\n\n

Cell-state transitions and density-dependent interactions together explain the dynamics of spontaneous epithelial-mesenchymal heterogeneity. <\/strong>
Jain P,<\/span> Ramanarayanan K,<\/span> Nair MB<\/span>, Bhatia S, Thompson EW, George JT#<\/sup><\/strong>, Jolly MK#<\/sup><\/strong> (2024) iScience, 27 (7): 110310<\/em><\/a><\/p>\n\n\n\n

A multistep growth model of high grade serous ovarian carcinoma identifies hypoxia driven signatures. <\/strong>
More MH, Varankar S, Naik RR, Dhake RD, Ray P, Bankar RM, Mali AM, Subbalakshmi AR,<\/span> Chakraborty P<\/span>, Jolly MK<\/strong>, Bapat SA (2024) Cells Tissues Organs, 213 (2): 79-95<\/em><\/a><\/p>\n\n\n\n

Spatial heterogeneity in cell adhesion qualifies collective cell invasion.<\/strong>
Prasanna CVS<\/span>, Jolly MK#<\/sup><\/strong>, Bhat R#<\/sup> (2024). Biophysical Jou<\/em><\/a>rnal, 123 (12): 1635-1647<\/em><\/a><\/p>\n\n\n\n

Elucidating the role of microRNA-18a in propelling a hybrid epithelial-mesenchymal phenotype and driving malignant progression in ER-negative breast cancer.<\/strong>
Nair MG, Mavatkar AD, Naidu CM, Snijesh VP, Anupama CE, Rajarajan S, Sahoo S<\/span>, Mohan G, Jaikumar VS, Ramesh RS, Srinath BS, Jolly MK<\/strong>, Maliekal TT, Prabhu JS (2024). Cells, 13 (10): 821<\/em><\/a><\/p>\n\n\n\n

Increased prevalence of hybrid epithelial-mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer.<\/strong>
Sahoo S,<\/span> Soundharya R<\/span>, Nair MG, Pillai M<\/span>, Juan BSP, Milioli HZ, Mandal S<\/span>, Naidu CM, Mavatkar AD, Subramaniam H,<\/span> Neogi AG<\/span>, Chaffer CL, Prabhu JS, Somarelli JA, Jolly MK#<\/sup><\/strong> (2024). iScience 27 (7), 110116<\/em><\/a><\/p>\n\n\n\n

Differential role of glucocorticoid receptor based on its cell type specific expression on tumor cells and infiltrating lymphocytes.<\/strong>
Snijesh VP, Nimbalkar VP, Patil S, Rajarajan S, Anupama CE, Mahalakshmi S, Alexander A, Soundharya R<\/span>, Ramesh R, Srinath BS, Jolly MK<\/strong>, Prabhu JS (2024). Translational Oncology, 45: 101957<\/a><\/em><\/p>\n\n\n\n

Perspectives on polarity \u2013 exploring biological asymmetry across scales.<\/strong>
Glazenburg M, Hettema N, Laan L, Remy O, Laloux G, Brunet T, Chen X, Tee YH, Wen W, Rizvi MS, Jolly MK<\/strong>, Riddell M (2024). Journal of Cell Science, 137 (5): jcs261987<\/em><\/a><\/p>\n\n\n\n

Dynamics of T-helper cell differentiation and plasticity: how have computational models improved our understanding?<\/strong>
Harlapur P,<\/span> Duddu AS<\/span>, Jolly MK#<\/sup><\/strong> (2024). Current Opinion in Systems Biology, 37: 100508<\/em><\/a><\/p>\n\n\n\n

Protocol for inferring epithelial-to-mesenchymal transition trajectories from single-cell RNA-sequencing data using R.<\/strong>
Najafi A, Jolly MK#<\/sup><\/strong>, George JT#<\/sup> (2024). STAR Protocols, 5 (1): 102819<\/a><\/em><\/p>\n\n\n\n

Proneural-mesenchymal antagonism dominates the patterns of phenotypic heterogeneity in glioblastoma.<\/strong>
BV Harshavardhan<\/span>, Jolly MK#<\/sup><\/strong> (2024). iScience, 27: 109184<\/em><\/a><\/p>\n\n\n\n

Mutually exclusive teams-like patterns of gene expression characterize phenotypic heterogeneity along the noradrenergic-mesenchymal axis in neuroblastoma.<\/strong>
Sehgal M, Nayak SP, Sahoo S<\/span>, Somarelli J#<\/sup><\/strong>, Jolly MK#<\/sup><\/strong> (2024). Cancer Biology & Therapy, 25 (1): 2301802<\/em><\/a><\/p>\n\n\n\n

The exostosin glycosyltransferase 1 (EXT1)\/STAT3 axis is a driver of breast cancer aggressiveness.<\/strong>
Solaimuthu B, Khatib A, Tanna M, Karmi A, Hayashi A, Rmailah AA, Lichtenstein M, Takoe S<\/span>, Jolly MK<\/strong>, Shaul YS (2024). Proceedings of the National Academy of Sciences USA (PNAS), 121 (3): e2316733121<\/em><\/a><\/p>\n\n\n\n

Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancer.<\/strong>
Sharma S, Rani H, Yeshwanth M<\/span>, Jolly MK<\/strong>, Mahadevan V (2024). Translational Oncology, 43: 101848<\/a><\/em><\/p>\n\n\n\n

Characterizing heterogeneity along EMT and metabolic axes in colorectal cancer reveals underlying consensus molecular subtype-specific trends.<\/strong>
Sehgal M,<\/span> Soundharya R,<\/span> Vaz JM,<\/span> Yogeshwar RG,<\/span> Muralidharan S,<\/span> Venkatraghavan S<\/span>, Jolly MK#<\/sup><\/strong> (2024). Translational Oncology, 40: 101845<\/em><\/a><\/p>\n\n\n\n

Dual role of CASP8AP2\/FLASH in regulating epithelial-to-mesenchymal transition (EMT).<\/strong>
Catalanotto M*, Vaz JM<\/span>*, Abshire C, Youngblood R, Chu M, Levine H, Jolly MK<\/strong>, Dragoi AM (2024). Translational Oncology, 39: 101837<\/em><\/a><\/p>\n\n\n\n

Transcriptional state dynamics leads to heterogeneity and adaptive tumor evolution in urothelial bladder carcinoma.<\/strong>
Sahu S, Sahoo S<\/span>, Sullivan T, O\u2019Sullivan N, Turan S, Albaugh ME, Burkett SK, Tran B, Salomon DS, Kozlov SV, Koehler KR, Jolly MK<\/strong>, Sharan SK (2024). Developmental Cell, 59 (2): 175-186.e8<\/a><\/em><\/p>\n\n\n\n

An endosomal acid-regulatory feedback system rewires cytosolic cAMP metabolism and drives tumour progression.<\/strong>
Prasad H, Mandal S<\/span>, Mathew JKK, Duddu AS,<\/span> Subbalakshmi AR,<\/span> Cherukunnath A, Banerjee M, Ramani H, Bhat R, Jolly MK<\/strong>, Visweswariah S (2024). <\/em>Molecular Cancer Research, <\/em>22 (5): 465\u2013481.<\/a><\/p>\n<\/div><\/div>\n\n\n\n

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2023<\/span><\/h4>\n\n\n\n

Transcriptional state dynamics leads to heterogeneity and adaptive tumor evolution in urothelial bladder carcinoma.<\/strong>
Biswas A, Sahoo S<\/span>, Riedlinger GR, Ghodoussipour S, Jolly MK<\/strong>, De S (2023). Communications Biology, 6: 1292<\/em><\/a><\/p>\n\n\n\n

A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticity.<\/strong>
Shyam S<\/span>, Soundharya R<\/span>, Sehgal M<\/span>, Jolly MK#<\/sup><\/strong> (2023). Journal of the Royal Society Interface, 20: 20230389<\/em><\/a><\/p>\n\n\n\n

Dynamical hallmarks of cancer: phenotypic switching in melanoma and epithelial-mesenchymal plasticity.<\/strong>
Jain P,<\/span> Pillai M<\/span>, Somarelli JA, Goyal Y, Jolly MK#<\/sup><\/strong> (2023). Seminars in Cancer Biology, 96: 48-63<\/em><\/a><\/p>\n\n\n\n

Effects of microRNA-mediated negative feedback on gene expression noise.<\/strong>
Adhikary R, Roy A, Jolly MK<\/strong>, Das D (2023). Biophysical Journal, 122 (21): 4220-4240<\/a><\/em><\/p>\n\n\n\n

Phenotypic heterogeneity drives differential disease outcome in triple negative breast cancer.<\/strong>
Thankamony AP, Murali R, Chakraborty P<\/span>, Karthikeyan N, Vargheses BA, Jaikumar VS, Jolly MK<\/strong>, Nair R (2023). Frontiers in Oncology, 13: 1230647<\/em><\/a><\/p>\n\n\n\n

Synthetic gene circuits combining CRISPR interference and CRISPR activation in E.coli: importance of equal guide RNA binding affinities to avoid context-dependent effects.<\/strong>
Barbier I, Kusumawadhani H*<\/sup>, Chauhan L<\/span>*<\/sup>, Harlapur PV<\/span>, Jolly MK<\/strong>, Schaerli Y (2023). ACS Synthetic Biology, 12 (10): 3064-71<\/em><\/a><\/p>\n\n\n\n

Dynamical modelling of proliferative-invasive plasticity and IFN\u03b3 signaling reveals mechanisms of PD-L1 expression heterogeneity in melanoma.<\/strong>
Subhadarshini S*<\/span>, Sahoo S*<\/span>, Debnath S, Somarelli JA, Jolly MK<\/strong>#<\/sup> (2023). Journal for ImmunoTherapy of Cancer, 11: e006766<\/em><\/a><\/p>\n\n\n\n

Androgen receptor driven gene score identified tumors with epithelial to mesenchymal transition features in triple negative breast cancer.<\/strong>
Rajarajan S, Snijesh VP, Anupama CE, Nair SJ, Mavetkar AD, Naidu CM, Patil S, Nimbalkar VP, Pillai M<\/span>, Jolly MK<\/strong>, Radhakrishnan S, Ramesh RS, Srinath BS, Prabhu JS (2023). Translational Oncology, 37:101761<\/em><\/a><\/p>\n\n\n\n

p53 amyloid pathology is correlated with cancer grades irrespective of the mutant or wildtype forms.<\/strong>
Sengupta S, Singh N, Paul A, Datta D, Chatterjee D, Mukherjee S, Gadhe L, Devi J, Yeshwanth M<\/span>, Jolly MK<\/strong>, Maji S (2023). Journal of Cell Science, 136 (17): jcs261017<\/a><\/em><\/p>\n\n\n\n

Theoretical and computational tools to model multistable gene regulatory networks.<\/strong>
Bocci F, Jia D, Nie Q, Jolly MK<\/strong>, Onuchic J (2023). Reports on Progress in Physics, 86 (10): 106601<\/a><\/em><\/p>\n\n\n\n

Unraveling the dangerous duet between cancer stem cell plasticity and drug resistance.<\/strong>
Chatterjee N, Pulipaka B, Subbalakshmi AR<\/span>, Jolly MK<\/strong>, Nair R (2023). Computational and Systems Oncology, 3 (3): e1051<\/a><\/em><\/p>\n\n\n\n

Collective heterogeneity of mitochondrial potential in contact inhibition of proliferation.<\/strong>
Thurakkal B, Hari K<\/span>, Marwaha R, Karki S, Jolly MK<\/strong>#<\/sup>, Das T#<\/sup> (2023). Biophysical Journal, 122 (19): 3909-3923<\/em><\/a><\/p>\n\n\n\n

Assessing biological network dynamics: comparing numerical simulations with analytical decomposition of parameter space.<\/strong>
Hari K<\/span>, Duncan W, Ibrahim MA<\/span>, Jolly MK<\/strong>#<\/sup>, Cummins B#<\/sup>, Gedeon T#<\/sup> (2023). NPJ Systems Biology & Applications, 9: 29<\/a><\/em><\/p>\n\n\n\n

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK\/STAT signaling as a therapeutic vulnerability in prostate cancer.<\/strong>
Ware KE, Thomas BC, Olawuni P, Sheth MU, Hawkey N, Yeshwanth M<\/span>, Miller BC, Vietor KJ, Jolly MK<\/strong>, Kim SY, Armstrong AM, Somarelli JA (2023). Frontiers in Molecular Biosciences, 10: 1104505<\/em><\/a><\/p>\n\n\n\n

Aberrations in ion channels interacting with lipid metabolism and epithelial mesenchymal transition in esophageal squamous cell carcinoma.<\/strong>
Parthasarathi KTS, Mandal S<\/span>, George JP, Gaikwad KB, Sasidharan S, Gundimeda S, <\/em>Jolly MK<\/strong>, Pandey A, Sharma J (2023). Frontiers in Molecular Biosciences, 17:10:1201459<\/em><\/a><\/p>\n\n\n\n

Link updating strategies influence consensus decisions as a function of the direction of communication.<\/strong>
Kunjar S<\/span>, Strandburg-Peshkin A, Giese H, Sarkar S, Jolly MK<\/strong>, Gradwohl N (2023). <\/span>Royal Society Open Science, 10: 230215<\/em><\/a><\/p>\n\n\n\n

Prognostic association of immunoproteasome expression in solid tumours is governed by the immediate immune environment.<\/strong>
<\/em>Kumar R, Dhaka B, Sahoo S<\/span>, Jolly MK<\/strong>, Radhakrishnan S (2023). Molecular Oncology, 17 (6): 1041-1059<\/a><\/em><\/p>\n\n\n\n

Population dynamics of EMT elucidates the timing and distribution of intra-tumoral heterogeneity.<\/strong>
Najafi A, Jolly MK<\/strong>#<\/sup><\/em>, George JT#<\/sup> (2023). iScience, 26 (7): 106964<\/em><\/a><\/p>\n\n\n\n

Modeling collective cell behavior in cancer: perspectives from an interdisciplinary conversation.<\/strong>
Adler FA, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GE, Ferrall-Fairbanks MC, Gartner ZC, Germain RN, Gordon DM, Hunter G, Jolly MK<\/strong>, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KL, Pe\u2019er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Szeto GL, Tomlin CJ, Yanai I, Zervantonakis IK, Dueck H (2023). Cell Systems, 14 (4): 252-257<\/em><\/a><\/p>\n\n\n\n

PRAME is a novel target of tumor-intrinsic Gas6\/Axl activation and promotes cancer cell invasion in hepato-cellular carcinoma.<\/strong>
Hedrich V, Breitenecker K, Ortmayr G, Pupp F, Huber H, Chen D, Sahoo S<\/span>, Jolly MK<\/strong>, Mikulits W (2023). Cancers, 15 (9): 2415<\/em><\/a><\/p>\n\n\n\n

Unraveling non-genetic heterogeneity in cancer with dynamical models and computational tools.<\/strong>
Pillai M<\/span>, Hojel E, Jolly MK<\/strong>#<\/sup><\/em>, Goyal Y#<\/sup> (2023). Nat Comput Sci, 3: 301-313<\/em><\/a><\/p>\n\n\n\n

Dynamics of epithelial-mesenchymal plasticity: what have single-cell investigations elucidated so far?<\/strong>
Subhadarshini S, Sahoo S, Vaz JM<\/span>, Jolly MK<\/strong>#<\/sup><\/em> (2023). ACS Omega, 8 (13): 11665-11673<\/em><\/a><\/p>\n\n\n\n

Partial EMT and associated changes in cellular plasticity in oncovirus-positive samples.<\/strong>
Sehgal M*, Ray R*, Vaz JM, Kanikar S<\/span>, Somarelli JA, Jolly MK<\/strong>#<\/sup><\/em> (2023). Advances in Cancer Biology – Metastasis, 7: 100091<\/em><\/a><\/p>\n\n\n\n

The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition.<\/strong>
Subbalakshmi AR*, Sahoo S*, Manjunatha P, Goyal S, Kasiviswanthan VA, Yeshwanth M, Soundharya R<\/span>, McMullen I, Somarelli JA#<\/sup><\/strong>, Jolly MK<\/strong>#<\/sup> <\/em>(2023). Journal of Biological Engineering, 17: 17<\/a><\/em><\/p>\n\n\n\n

Mapping spatiotemporal heterogeneity in tumor progression by integrating high-throughput imaging and omics analysis.<\/strong>
Patkulkar PA*, Subbalakshmi AR*<\/span>, Jolly MK<\/strong>#<\/sup><\/em>, Sinharay S# <\/sup>(2023). <\/a>ACS Omega, 8 (7):6126-6138<\/em><\/a><\/p>\n\n\n\n

Coupled mutual inhibition and mutual activation motifs as tools for cell-fate control.<\/strong>
Sabuwala B*, Hari K*<\/span>, Abhishek SV<\/span>, Jolly MK<\/strong>#<\/sup><\/em> (2023). Cells Tissues Organs, <\/em>213 (4): 283-296<\/a><\/p>\n\n\n\n

Unique sphingolipid signature identifies luminal and triple-negative breast cancer subtypes.<\/strong>
Kar A, Medatwal N, Rajput K, Mandal S<\/span>, Pani T, Khan A, Shamra P, Oberoi A, Vishwakarma G, Deo S, Jolly MK<\/strong>, Bajaj A, Dasgupta U (2023). International Journal of Cancer, 152 (11): 2410-2423<\/em><\/a><\/p>\n\n\n\n

Epigenetic memory acquired during long-term EMT induction governs the recovery to the epithelial state.<\/strong>
Jain P<\/span>, Corbo S, Mohammad K, Sahoo S<\/span>, Ranganathan S, George JT, Levine H, Taube J, Toneff M, Jolly MK<\/strong>#<\/sup><\/em> (2023). Journal of the Royal Society Interface, 20: 20220627<\/em><\/a><\/p>\n\n\n\n

Spatio-temporal Pattern Formation due to Host-Circuit Interplay in Gene Expression Dynamics.<\/strong>
Chakraborty P, Roy U<\/span>, Jolly MK<\/strong>, Ghosh S (2023). Chaos, Solitons & Fractals, 167: 112995<\/a><\/em><\/p>\n\n\n\n

Spatiotemporal patterning enabled by gene regulatory networks.<\/strong>
Roy U*, Singh D*, Vincent N, Haritas CK<\/span>, Jolly MK<\/strong>#<\/sup><\/em> (2023). ACS Omega, 8 (4): 3713-3725<\/em><\/a><\/p>\n<\/div><\/div>\n\n\n\n

\n

2022<\/span><\/h4>\n\n\n\n

Emergent dynamics of underlying regulatory network links EMT and androgen receptor-dependent resistance in prostate cancer.<\/strong>
Jindal R*, Nanda A*<\/span>, Pillai M, Ware KE, Singh D, Sehgal M<\/span>, Armstrong AJ, Somarelli JA#<\/sup>, Jolly MK<\/strong>#<\/sup> <\/em>(2022). Computational & Structural Biotechnology Journal, 21: 1498-1509<\/em><\/a><\/p>\n\n\n\n

Functional resilience of mutually repressing motifs embedded in larger networks.<\/strong>
Harlapur P, Duddu AS, Hari K, Kulkarni P,<\/span> <\/em>Jolly MK<\/strong>#<\/sup><\/em> (2022). Biomolecules, 12 (12): 1842<\/em><\/a><\/p>\n\n\n\n

Network topology metrics explaining enrichment of hybrid epithelial mesenchymal phenotypes in metastasis.<\/strong>
Rashid M*, Hari K*, Thampi J, Santhosh KN,<\/span> Jolly MK<\/strong>#<\/sup> (<\/em>2022). <\/a>PLoS Computational Biology, 18 (11): e1010687<\/em><\/a><\/p>\n\n\n\n

PD-L1 activity is associated with partial EMT and metabolic reprogramming in carcinomas.<\/strong>
Muralidharan S*, Sehgal M*, Soundharya R*, Mandal S, Majumdar SS, Yeshwanth M, Saha A, <\/span>Jolly MK<\/strong>#<\/sup> (2022).<\/span> Current Oncology, 29 (11): 8285-8301<\/em><\/a><\/p>\n\n\n\n

Landscape of epithelial-mesenchymal plasticity as an emergent property of coordinated modules in regulatory networks.<\/strong>
Hari K, Ullanat U, Balasubramanian A, Gopalan A<\/span>, Jolly MK<\/strong>#<\/sup> (2022). eLife, 11: e76535<\/em><\/a><\/p>\n\n\n\n

Spatiotemporal patterning enabled by gene regulatory networks.<\/strong>
Roy U*, Singh D*, Vincent N, Haritas CK,<\/span> Jolly MK<\/strong>#<\/sup> (2022). ACS Omega, 8: 3713-3725<\/a><\/em><\/p>\n\n\n\n

Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanoma.<\/strong>
Pillai M*<\/span>, Chen Z*, Jolly MK<\/strong>#<\/sup>, Li C#<\/sup> (2022). iScience, 25 (12): 105499<\/em><\/a><\/p>\n\n\n\n

Emergent properties of coupled bistable switches.<\/strong>
Hari K*, Harlapur P*, Gopalan A, Ullanat V, Duddu AS<\/span>, Jolly MK<\/strong>#<\/sup> (2022). <\/em>Journal of BioSciences, 47: 81<\/em><\/a><\/p>\n\n\n\n

Stochastic population dynamics of cancer stemness and adaptive response to therapies.<\/strong>
Jain P, Duddu AS<\/span>, Jolly MK<\/strong>#<\/sup> (2022). Essays in Biochemistry, 66 (4): 387-398<\/em><\/a><\/p>\n\n\n\n

Dynamics of a hepatocyte-cholangiocyte decision-making gene regulatory network during liver development and regeneration.<\/strong>
Sahoo S, Mishra A,<\/span> Diehl AM, Jolly MK<\/strong>#<\/sup> (2022). iScience, 25 (9): 104955<\/em><\/a><\/p>\n\n\n\n

Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis.<\/strong>
Pillai M*, Rajaram G*, Thakur P, Agarwal N, Muralidharan S, Ray A<\/span>, Somarelli JA, Jolly MK<\/strong>#<\/sup> (2022). Frontiers in Oncology, 12: 913803<\/em><\/a><\/p>\n\n\n\n

Lack of correlation between landscape geometry and transition rates.<\/strong>
Jia W, Duddu AS<\/span>, Jolly MK<\/strong>, Levine H#<\/sup> (2022). Journal of Physical Chemistry B, 126 (30): 5613-8<\/em><\/a><\/p>\n\n\n\n

Robustness in phenotypic plasticity and heterogeneity patterns enabled by EMP networks.<\/strong>
Hebbar A*, Moger A*, Hari K<\/span>, Jolly MK<\/strong>#<\/sup> (2022). Biophysical Journal, 121 (19): 3600-15<\/em><\/a><\/p>\n\n\n\n

Cell geometry distinguishes migration-associated heterogeneity in two-dimensional systems.<\/strong>
Varankar S, Hari K, Kartika S<\/span>, Bapat SA#<\/sup>, Jolly MK<\/strong>#<\/sup> (2022). Computational and Systems Oncology, 2 (3): e1041<\/em><\/a><\/p>\n\n\n\n

P4HA2: a link between tumor-intrinsic hypoxia, partial EMT and collective migration.<\/strong>
Aggarwal V, Sahoo S<\/span>, Donnenberg VS, Chakraborty P<\/span>, Jolly MK<\/strong>, Sant S (2022). Advances in Cancer Biology \u2013 Metastasis, 5:100057<\/em><\/a><\/p>\n\n\n\n

Oncogenic gain of cellular function by p53 amyloid due to aberrant alteration of cell cycle and proliferation.<\/strong>
Navalkar A, Pandey S, Paul A, Dey A, Saha S, Sahoo S<\/span>, Jolly MK<\/strong>, Maiti TK, Maji SM (2022). Journal of Cell Science, 135 (15): jcs259500<\/em><\/a><\/p>\n\n\n\n

A multistep growth model of high grade serous ovarian carcinoma identifies hypoxia driven signatures.<\/strong>
More MH, Varankar S, Naik RR, Dhake RD, Ray P, Bankar RM, Mali AM, Subbalakshmi AR, Chakraborty P<\/span>, Jolly MK<\/strong>, Bapat SA (2022). Cells Tissues Organs, 213(2): 79-95<\/a><\/em><\/p>\n\n\n\n

Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer.<\/strong>
Brown MS, Abdollahi B, Wilkins OM, Lu H, Chakraborty P<\/span>, Ognjenovic NB, Muller KE, Jolly MK<\/strong>, Christensen BC, Hassanpour S, Pattabiraman D (2022). Science Advances, 8 (31): abj8002<\/em><\/a><\/p>\n\n\n\n

Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos.<\/strong>
Naik K, Hari K<\/span>, Chandel C, Jolly MK<\/strong>, Gayen S (2022). iScience, 25 (6): 104465<\/em><\/a><\/p>\n\n\n\n

Spontaneous differentiation leads to emergence of hybrid cell states related to poor prognosis in oral cancer.<\/strong>
Vipparthi K, Hari K<\/span>, Chakraborty P<\/span>, Ghosh S, Patel AK, Ghosh A, Biswas NK, Sharan R, Arun P, Jolly MK<\/strong>, Singh S (2022). iScience, 25(5): 104317<\/em><\/a><\/p>\n\n\n\n

Analysis of Yes-associated protein 1 (YAP1) target gene signature to predict a progression subset of breast cancer.<\/strong>
Gomathi V, Kelkar DA, Mandal S<\/span>, Jolly MK<\/strong>, Kulkarni M (2022). Journal of Clinical Medicine, 11 (7): 1947<\/em><\/a><\/p>\n\n\n\n

Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1\/Th2\/Th17 differentiation.<\/strong>
Duddu AS, Majumdar SS, Sahoo S<\/span>, Jhunjhunwala S, Jolly MK<\/strong>#<\/sup> (2022). Molecular Biology of the Cell, 33 (6): ar46<\/em><\/a><\/p>\n\n\n\n

Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary.<\/strong>
Singh N, Singh D, Bhide A, Sharma R, Sahoo S<\/span>, Jolly MK<\/strong>, Modi D (2022). Experimental Cell Research, 415: 113108 <\/a><\/em><\/p>\n\n\n\n

Emerging perspectives on growth factor metabolic relationships in the ovarian cancer ascites environment.<\/strong>
Monavarian M, Elhaw A, Tang P, Javed Z, Shonibare Z, Scalise CB, Arend R, Jolly MK<\/strong>, Sewell-Loftin MK, Hempel N, Mythreye K (2022). Seminars in Cancer Biology, 86(Pt 2):709-719<\/em><\/a><\/p>\n\n\n\n

Population dynamics of epithelial-mesenchymal heterogeneity in cancer cells.<\/strong>
Jain P<\/span>, Bhatia S, Thompson EW#<\/sup>, Jolly MK<\/strong>#<\/sup> (2022). Biomolecules, 12 (3): 348<\/em><\/a><\/p>\n\n\n\n

In silico analysis of ion channels and its correlation with epithelial to mesenchymal transition in breast cancer.<\/strong>
Parthasarathy KTS, Mandal S<\/span>, Singh S, Gundimeda S, Jolly MK<\/strong>, Pandey A, Sharma J (2022). Cancers, 14 (6): 1444<\/em><\/a><\/p>\n\n\n\n

Nrf2 modulates the hybrid epithelial\/mesenchymal phenotype and Notch signaling during collective cancer migration.<\/strong>
Mercedes SAV, Bocci F, Eder I, Ahmed M, Zhu N, Levine H#<\/sup>, Onuchic JN#<\/sup>, Jolly MK<\/strong>#<\/sup>, Wong PK#<\/sup> (2022). Frontiers in Molecular Biosciences, 9: 807324<\/em><\/a><\/p>\n\n\n\n

Quantifying the patterns of metabolic plasticity and heterogeneity along the epithelial-hybrid-mesenchymal spectrum in cancer.<\/strong>
Muralidharan S, Sahoo S, Saha A*, Chandran S*, Majumdar SS*<\/span>, Levine H#<\/sup>, Jolly MK<\/strong>#<\/sup> (2022). Biomolecules, 12 (2): 297<\/em><\/a><\/p>\n\n\n\n

Intrinsically disordered proteins: ensembles at the limits of Anfinsen\u2019s dogma.<\/strong>
Kulkarni P, Leite VBP, Roy S, Bhattacharyya S, Mohanty A, Achuthan S, Singh D<\/span>, Appadurai R, Rangarajan G, Weninger K, Orban J, Srivastava A, Jolly MK<\/strong>, Onuchic JN, Uversky VU, Salgia R (2022). Biophysics Reviews, 3: 011306<\/em><\/a><\/p>\n\n\n\n

Mean residence times of TF-TF and TF-miRNA toggle switches.<\/strong>
Biswas K, Jolly MK<\/strong>, Ghosh A (2022). Journal of Biosciences, 47: 26<\/em><\/a><\/p>\n\n\n\n

Identifying critical transitions in complex diseases.<\/strong>
Deb S, Bhandary S, Sinha SK, Jolly MK<\/strong>, Dutta PS (2022). Journal of Biosciences, 47: 25<\/em><\/a><\/p>\n\n\n\n

Roadmap on plasticity and epigenetic in cancer.<\/strong>
Foo J, Basanta D, Rockne R, Strelez C, Shah C, Ghaffarian K, Mumenthaler SM, Mitchell K, Lathia JD, Frankhouser D, Branciamore S, Kuo Y-H, Marcucci G, Velde RV, Marusyk A, Huang S, Hari K<\/span>, Jolly MK<\/strong>, Hatzikirou H, Poels KE, Spilker ME, Shtylla B, Robertson-Tessi M, Anderson ARA (2022). Physical Biology, 19 (3): 031501<\/em><\/a><\/p>\n\n\n\n

Tumor hybrid cells: nature and biological significance.<\/strong>
Tretyakova MS, Subbalakshmi AR<\/span>, Menyailo ME, Jolly MK<\/strong>, Denisov EV (2022). Frontiers in Cell and Developmental Biology<\/em>, 10: 814714<\/a><\/p>\n\n\n\n

NRF2-dependent epigenetic regulation can promote the hybrid epithelial\/ mesenchymal phenotype.<\/strong>
Jia W, Jolly MK#<\/sup><\/strong>, Levine H#<\/sup> (2022). Frontiers in Cell and Developmental Biology, 9:828250<\/em><\/a><\/p>\n\n\n\n

Biophysical and biochemical attributes of hybrid epithelial\/ mesenchymal phenotypes.<\/strong>
Subbalakshmi AR, Ashraf B<\/span>, Jolly MK#<\/sup><\/strong> (2022). Physical Biology, 19<\/strong>(2):025001<\/em><\/a><\/p>\n\n\n\n

Cancer: more than a geneticist\u2019s Pandora\u2019s box.<\/strong>
Saxena K, Subbalakshmi AR<\/span>, Kulkarni P, Jolly MK#<\/sup><\/strong> (2022). <\/a>Journal of BioSciences,  47<\/strong>:21<\/em><\/a><\/p>\n\n\n\n

Changes in triple-negative breast cancer molecular subtype in patients without pathological complete response after neoadjuvant systemic therapy.<\/strong>
Masuda H, Harano K, Miura S, Wang Y, Hirota Y, Harada O, Jolly MK<\/strong>, Matsunaga Y, Lim B, Wood AL, Parinyanitikul N, Lee HJ, Gong G, George JT, Levine H, Lee J, Wang X, Lucci A, Rao A, Schweitzer BL, Lawrence OR, Seitz RS, Morris SW, Hout DR, Nakamura S, Krishnamurthy S, Ueno NT (2022). JCO Precision Oncology<\/em>, 6:e2000368<\/a><\/p>\n\n\n\n

Interconnected high-dimensional landscapes of epithelial-mesenchymal plasticity and stemness.<\/strong>
Sahoo S, Ashraf B, Duddu AS<\/span>, Biddle A#<\/sup><\/strong>, Jolly MK<\/strong>#<\/sup><\/strong> (2022). Clinical & Experimental Metastasis, 39(2):279-290<\/em><\/a><\/p>\n\n\n\n

Quantitative systems pharmacology model-based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3-kinase (PI3K) inhibitors.<\/strong>
Gadkar K, Friedrich C, Hurez V, Ruiz M-L, Dickman L, Jolly MK<\/strong>, Schutt L, Jin J, Ware JA, Ramanujan S (2022). CPT: Pharmacometrics & Systems Pharmacology<\/em>, 11(5):616-627<\/em><\/a><\/p>\n\n\n\n

Protein conformational dynamics and phenotypic switching. <\/strong>
Kulkarni P, Achuthan S, Bhattacharya S, Jolly MK<\/strong>, Kotnala S, Leite VBP, Mohanty A, Orban J, Roy S, Rangarajan G, Salgia R (2022).Biophysical Reviews<\/em>, 13(6):1127-1138<\/em><\/a><\/p>\n\n\n\n

CTCF expression and dynamic motif accessibility modulates epithelial-mesenchymal gene expression. <\/strong>
Johnson KS, Hussein S, Chakraborty P<\/span>, Muruganantham A, Mikhail S, Gonzalez G, Song S, Jolly MK<\/strong>, Toneff M, Benton ML, Lin YC, Taube JH (2022).Cancers<\/em>, 14(1):209<\/a><\/p>\n\n\n\n

A reciprocal feedback loop between HIF1\u03b1 and HPIP controls phenotypic plasticity in breast cancer cells.<\/strong>
Khumukcham SS, Penugruti V, Soni A, Uppala V, Hari K<\/span>, Jolly MK<\/strong>, Dwivedi A, Salam PKA, Padala C, Mukta S, Triveni B, Bramanandam MB (2022). Cancer Letters, <\/em>526: 12-28<\/a><\/p>\n\n\n\n

Transcriptomic-based quantification of epithelial-hybrid-mesenchymal spectrum across biological contexts.<\/strong>
Mandal S, Tejaswi T, Janivara R, Srikrishnan S, Thakur P, Sahoo S, Chakraborty P<\/span>, Sohal SS, Levine H, George JT#<\/sup>, Jolly MK<\/strong>#<\/sup><\/strong> (2022). Biomolecules<\/em>, 12 (1): 29<\/a><\/p>\n\n\n\n

Dynamic phenotype switching and group behavior help non-small cell lung cancer cells evade chemotherapy. <\/strong>
Nam A, Mohanty A, Bhattacharya S, Kotnala S, Achuthan S, Hari K<\/span>, Srivastava S, Guo L, Nathan A, Chatterjee R, Jain M, Nasser MW, Batra S, Rangarajan G, Massarelli E, Levine H, Jolly MK<\/strong>, Kulkarni P, Salgia R (2022).Biomolecules<\/em>, 12 (1): 8<\/a><\/p>\n<\/div><\/div>\n\n\n\n

\n

2021<\/span><\/h4>\n\n\n\n

Immunosuppressive traits of hybrid epithelial\/mesenchymal phenotype.<\/strong>
Sahoo S*, Nayak SP*, Hari K, Purkait P, Mandal S, Kishore A<\/span>, Levine H, Jolly MK<\/strong>#<\/sup><\/strong> (2021). Frontiers in Immunology<\/em>, 12: 797261<\/a><\/p>\n\n\n\n

KLF4 induces mesenchymal-epithelial transition (MET) by suppressing multiple EMT-inducing transcription factors. <\/strong>
Subbalakshmi AR, Sahoo S<\/span>, McMullen I, Saxena A, Venugopal SK<\/span>, Somarelli JA#<\/sup>, Jolly MK<\/strong>#<\/sup><\/strong> (2021). Cancers<\/em>, 13 (20): 5135<\/a><\/p>\n\n\n\n

Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma.<\/strong>
Pillai M<\/span>, Jolly MK<\/strong>#<\/sup><\/strong> (2021). iScience, <\/em>24: 103111<\/a><\/p>\n\n\n\n

First passage time properties of miRNA-mediated protein translation.<\/strong>
Biswas K, Jolly MK<\/strong>, Ghosh A (2021). Journal of Theoretical Biology, 529: 110863<\/em><\/a><\/p>\n\n\n\n

Semi-coordinated allelic-bursting shape dynamic random monoallelic expression in pregastrulation embryos.<\/strong>
Naik HC, Hari K<\/span>, Chandel D, Mandal S<\/span>, Jolly MK<\/strong>, Gayen S (2021). iScience<\/em>, 24 (9): 102954<\/a><\/p>\n\n\n\n

Lineage plasticity in cancer: The tale of a skin-walker.<\/strong>
Thankamony AP, Subbalakshmi AR<\/span>, Jolly MK<\/strong>#<\/sup><\/strong>, Nair R#<\/sup> (2021). Cancers<\/em>, 13 (14): 3602<\/a><\/p>\n\n\n\n

Calcium signaling induces a partial EMT.<\/strong>
Norgard RJ, Pitaressi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Roasrio-Berrios DN, Kim I-K, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P<\/span>, Jolly MK<\/strong>,<\/em> Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ. EMBO Reports<\/em>, 22 (9): e51872<\/a><\/p>\n\n\n\n

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells.<\/strong>
Sahoo S, Mishra A, Kaur H, Hari K, Muralidharan S, Mandal S<\/span>, Jolly MK<\/strong>#<\/sup><\/strong> (2021). NAR Cancer, <\/em>3 (3): zcab027<\/a><\/p>\n\n\n\n

Integrative systems biology approach identifies crucial genes and transcription factors associated with gallbladder cancer pathogenesis.<\/strong>
Roy N, Kshattry M, Mandal S<\/span>, Jolly MK<\/strong>, Bhattacharyya DK, Barah P (2021). Journal of Clinical Medicine, <\/em>10 (16): 3520<\/a><\/p>\n\n\n\n

First passage time properties of miRNA-mediated protein translation.<\/strong>
Biswas K, Jolly MK<\/strong>, Ghosh A (2021). Journal of Theoretical Biology<\/em>, 110863<\/a><\/p>\n\n\n\n

Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma.<\/strong>
Pillai M<\/span>, Jolly MK<\/strong>#<\/sup><\/strong> (2021). iScience 24 :<\/em>103111<\/a> <\/p>\n\n\n\n

Semi-coordinated allelic-bursting shape dynamic random monoallelic expression in pregastrulation embryos.<\/strong>
Naik HC, Hari K<\/span>, Chandel D, Mandal S<\/span>, Jolly MK<\/strong>, Gayen S (2021). iScience<\/em> 24 (9): 102954<\/a> <\/p>\n\n\n\n

Lineage plasticity in cancer: The tale of a skin-walker.<\/strong>
Thankamony AP, Subbalakshmi AR<\/span>, Jolly MK<\/strong>#<\/sup><\/strong>, Nair R#<\/sup> (2021). Cancers<\/em>, 13 (14): 3602<\/a><\/p>\n\n\n\n

Calcium signaling induces a partial EMT.<\/strong>
Norgard RJ, Pitaressi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Roasrio-Berrios DN, Kim I-K, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK<\/strong>, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ. EMBO Reports<\/em>, 7, 2021.<\/a><\/p>\n\n\n\n

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells.<\/strong>
Sahoo S<\/span>, Mishra A<\/span>, Kaur H<\/span>, Hari K<\/span>, Muralidharan S<\/span>, Mandal S<\/span>, Jolly MK<\/strong>#<\/sup><\/strong> (2021). NAR Cancer, <\/em>3 (3): zcab027<\/a><\/p>\n\n\n\n

Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum.<\/strong>
Chakraborty P<\/span>, Chen E, McMullen I, Armstrong A, Jolly MK<\/strong>#<\/sup><\/strong>, Somarelli JA#<\/sup><\/strong> (2021). Computational and Structural Biotechnology, <\/em>19: 3842-3851<\/a> <\/p>\n\n\n\n

Epithelial-to-mesenchymal transition enhances cancer cell sensitivity to cytotoxic effects of cold atmospheric plasmas in breast and bladder cancer systems.<\/strong>
Wang P, Zhou R, Thomas P, Zhao L, Zhou R, Mandal S<\/span>, Jolly MK<\/strong>, Richard DJ, Rehm BHA, Ostrikov K, Dai X, Williams ED, Thompson EW (2021). Cancers<\/em>, 13 (12): 2889<\/a><\/p>\n\n\n\n

Phenotypic heterogeneity of triple-negative breast cancer mediated by epithelial-mesenchymal plasticity.<\/strong>
Kvokackova B, Remsik J, Jolly MK<\/strong>, Soucek K (2021). Cancers<\/em>, 13 (9): 2188<\/a><\/p>\n\n\n\n

Decoding leader cells in collective cancer invasion.<\/strong>
Mercedes SAV, Bocci, F, Levine H#<\/sup><\/strong>, Onuchic JN#<\/sup><\/strong>, Jolly MK<\/strong>#<\/sup><\/strong>, Wong PK#<\/sup><\/strong> (2021). Nature Reviews Cancer<\/em>, 21, <\/strong>592\u2013604<\/a> <\/p>\n\n\n\n

Matrix adhesion and remodeling diversifies modes of cancer invasion across spatial scales.<\/strong>
Pramanik D, Jolly MK<\/strong>#<\/sup><\/em>, Bhat R#<\/sup> (2021). Journal of Theoretical Biology<\/em>, 524: 110733<\/a><\/p>\n\n\n\n

Identification of EMT signaling crosstalk and gene regulatory networks by single-cell sequencing.<\/strong>
Deshmukh AP, Vasaikar S, Tomczak K, Tripathi S, den Hollander P, Arslan E, Chakraborty P<\/span>, Soundararajan R, Jolly MK<\/strong>, Rai K, Levine H, Mani SA (2021). Proceedings of the National Academy of Sciences USA (PNAS), <\/em>118 (19): e2102050118<\/a><\/p>\n\n\n\n

Countries with high deaths dye to flu and tuberculosis demonstrate lower COVID-19 mortality: roles of vaccinations.<\/strong>
Pathak S, Jolly MK<\/strong>, Nandi D (2021). Human Vaccines & Immunotherapeutics, 17(9):2851-2862<\/a><\/em><\/p>\n\n\n\n

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer.<\/strong>
Chauhan L*, Ram U*, Hari K<\/span>, <\/em>Jolly MK#<\/sup><\/strong> (2021). eLife, 10: e64522<\/em><\/a><\/p>\n\n\n\n

Identifying \u201cmore equal than others\u201d edges in diverse biochemical networks.<\/strong>
Hari K, Ram U<\/span>, Jolly MK<\/strong>#<\/sup> (2021). Proceedings of the National Academy of Sciences USA (PNAS), <\/em>118 (16): e2103698118<\/a><\/p>\n\n\n\n

Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer.<\/strong>
Jia D, Park JH, Kaur H<\/span>, Jung KH, Yang S, Tripathi S, Galbraith M, Deng Y, Jolly MK<\/strong>, Kaipparettu BA, Onuchic JN, Levine H (2021). British Journal of Cancer, 124<\/strong>, 1902\u20131911<\/a><\/em><\/p>\n\n\n\n

Quantifying the epithelial \/mesenchymal hybrid state in cancer: clinical implications.<\/strong>
Jolly MK<\/strong>#<\/sup><\/strong>, Murphy RM, Bhatia S, Whitfield H, Davis MJ#<\/sup>, Thompson EW#<\/sup> (2021). Cells Tissues Organs, 2021<\/a><\/em><\/p>\n\n\n\n

Multistability and consequent phenotypic plasticity in AMPK-Akt double negative feedback loop in cancer cells.<\/strong>
Chedere A, Hari K<\/span>, Kumar S, Rangarajan A#<\/sup>, Jolly MK<\/strong>#<\/sup><\/strong> (2021). Journal of Clinical Medicine<\/em>, 10 (3): 472<\/a><\/p>\n\n\n\n

Gene expression profiling of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum.<\/strong>
Chakraborty P<\/span>, George JT, Woodward W, Levine H, Jolly MK<\/strong>#<\/sup><\/strong> (2021).Translational Oncology, <\/em>14 (4): 101026<\/a><\/p>\n\n\n\n

Hybrid E\/M phenotype(s) and stemness: a mechanistic connection embedded in network topology.<\/strong>
Pasani S, Sahoo S,<\/span> Jolly MK<\/strong>#<\/sup><\/strong> (2021).Journal of Clinical Medicine, <\/em>10(1): 60<\/a><\/p>\n\n\n\n

Group behavior and the emergence of cancer drug resistance.<\/strong>
Bhattacharya S, Mohanty A, Achuthan S, Kotnala S, Jolly MK<\/strong>, Kulkarni P, Salgia R (2021). Trends in Cancer<\/em>, 7 (4): 323-334<\/a> <\/p>\n<\/div><\/div>\n\n\n\n

\n

2020<\/span><\/h4>\n\n\n\n

A theoretical approach to coupling the epithelial-mesenchymal transition (EMT) to extracellular matrix (ECM) stiffness via LOXL2.<\/strong>
Deng Y, Chakraborty P<\/span>, Jolly MK#<\/sup><\/strong>, Levine H#<\/sup><\/strong> (2020). Cancers 13 (7):1609.<\/em><\/a><\/p>\n\n\n\n

Coupled feedback loops involving PAGE4, EMT and Notch signaling can give rise to non-genetic heterogeneity in prostate cancer cells.<\/strong>
Singh D<\/span>, Bocci F, Kulkarni P, Jolly MK<\/strong>#<\/sup><\/strong> (2020). Entrop<\/em>y 2021, 23 (3): 288<\/a> <\/p>\n\n\n\n

Operating principles of circular toggle polygons.<\/strong>
Hati S, Duddu AS<\/span>, Jolly MK#<\/sup><\/strong> (2020). Physical Biology 18<\/strong> 046003<\/em><\/a><\/p>\n\n\n\n

Investigating epithelial-mesenchymal heterogeneity of tumors and circulating tumor cells with transcriptomic analysis and biophysical modeling.<\/strong>
Bocci F<\/span>#<\/sup>, <\/span>Mandal S, Tejaswi T,<\/span> <\/span>Jolly MK<\/strong>#<\/sup><\/strong> (2020). <\/span>Computational and Systems Oncology<\/em> 2.1015<\/a><\/p>\n\n\n\n

A computational systems biology approach identifies SLUG as a mediator of partial Epithelial-Mesenchymal Transition.<\/strong>
Subbalakshmi A R, Sahoo S<\/span>, Biswas K, Jolly MK<\/strong>#<\/sup><\/strong> (2020). Cells Tissues Organs<\/a><\/em><\/p>\n\n\n\n

The Good, The Bad and The Ugly: A mathematical model investigates the differing outcomes among CoVID-19 patients.<\/strong>
Sahoo S,<\/span> Jhunjhunwala S, Jolly MK<\/strong>#<\/sup>(2020). Journal of the Indian Institute of Science<\/em>, 100 (4): 673-681<\/a><\/p>\n\n\n\n

Multistability in cellular differentiation enabled by a network of three mutually repressing master regulators.<\/strong>
Duddu AS, Sahoo S, Hati S<\/span>, Jhunjhunwala S, Jolly MK<\/strong>#<\/sup> (2020). Journal of the Royal Society Interface<\/em>, 17 (170): 20200631<\/a><\/p>\n\n\n\n

Targeting the Id1-Kif11 axis in triple negative breast cancer using combination therapy.<\/strong>
Archana PT*, Murali M*, Karthikeyan N, Varghese BA, Teo WS, McFarland A, Roden DL, Holliday H, Konrad CV, Cazet A, Dodson E, Yang J, Baker LA, George JT, Levine H, Jolly MK<\/strong>,<\/em> Swarbick A, Nair R (2020). Biomolecules<\/em>, 10 (9): 1295<\/a><\/p>\n\n\n\n

OVOL1\/2: Drivers of epithelial differentiation in development, disease and reprogramming.<\/strong>
Saxena K, Srikrishnan S<\/span>, Celia-Terrassa T, Jolly MK<\/strong># <\/sup><\/strong>(2020). Cells Tissues Organs<\/em>, 211(2):183-192<\/a><\/p>\n\n\n\n

NFATc acts as a non-canonical phenotypic stability factor for a hybrid epithelial\/mesenchymal phenotype.<\/strong>
Subbalakshmi A R<\/span>, Kundnani D, Biswas K, Hanash SM, Ghosh A, Tripathi SC#<\/sup>, Jolly MK<\/strong>#<\/sup><\/strong> (2020). Frontiers in Oncology<\/em>, 10: 553342<\/a><\/p>\n\n\n\n

Anticipating the novel coronavirus disease (COVID-19) pandemic.<\/strong>
Kaur T, Sarkar S, Chowdhury S, Sinha SK, Jolly MK<\/strong>, Dutta PS (2020). Frontiers in Public Health<\/em>, 89: 569669<\/a><\/p>\n\n\n\n

Hypoxia, partial EMT and collective migration: emerging culprits in metastasis.<\/strong>
Saxena K<\/span>, Jolly MK<\/strong>#<\/sup><\/em>,<\/sup> Balamurugan K#<\/sup> (2020). Translational Oncology, <\/em>13 (11): 100845<\/a><\/p>\n\n\n\n

Single cell RNAseq identifies subsets of cells in the feto-maternal interface that highly express factors that drive pathogenesis of SARS-CoV-2.<\/strong>
Ashray N, Bhide A, Chakraborty P<\/span>, Mishra A, Chhabria K, Jolly MK<\/strong>, Modi D (2020). Frontiers in Cell and Developmental Biology<\/em>, 8: 783<\/a><\/p>\n\n\n\n

A non-genetic mechanism for chemoresistance in lung cancer: the role of integrin \u03b24\/paxillin axis.<\/strong>
Mohanty A, Nam A, Pozhiktov A, Bhattacharyya S, Yang L, Nathan A, Xiewei W, Srivastava S, Mambetsariev I, Nelson M, Subbalakshmi A R<\/span>, Guo L, Nasser MW, Batra SK, Orban J, Jolly MK<\/strong>, Maserralli E, Kulkarni P, Salgia R (2020). iScience<\/em>, 23 (9): 101496<\/a><\/p>\n\n\n\n

Understanding the principles of pattern formation driven by Notch signaling through integratingexperiments and theoretical models.<\/strong>
Bocci F, Onuchic JN#<\/sup>, Jolly MK#<\/sup> <\/strong>(2020). Frontiers in Physiology, <\/em>11: 929<\/a><\/p>\n\n\n\n

Epigenetic feedback and stochastic cell division can drive resistance to EMT.<\/strong>
Jia D, Tripathi S, Chakraborty P<\/span>, Chedere A, Rangarajan A, Levine H#<\/sup>, Jolly MK<\/strong>#<\/sup><\/em> (2020). Oncotarget, <\/em>11 (27): 2611-2624<\/a><\/p>\n\n\n\n

A complex polycyclic aromatic hydrocarbon environmental chemical mixture promotes aggressive phenotype and survival signaling with hormone receptor selectivity in breast cancer cells.<\/strong>
Gearhart-Serna LM, Davis JB, Jolly MK<\/strong>, Jayasundara N, Saeur SJ, Giulio RD, Devi GR (2020). Carcinogenesis<\/em>, 41(12):1648-1659<\/em><\/a><\/p>\n\n\n\n

Cellular plasticity in matrix-attached and -detached cells: implications in metastasis.<\/strong>
Ranganathan S, Kumar S, Mohanty SS, Jolly MK<\/strong>, Rangarajan A (2020). Journal of the Indian Institute of Science<\/em>, 100 (3): 525-536<\/a><\/p>\n\n\n\n

Twist1 induces chromosomal instability (CIN) in colorectal cancer cells.<\/strong>
Khot M, Sreekumar D, Jahagirdar S, Kulkarni A, Hari K<\/span>, Faseela EE, Radhakrishnan S, Jolly MK<\/strong>, Sengupta K. Human Molecular Genetics<\/em>, 29 (10): 1673-88<\/a><\/p>\n\n\n\n

Integrative analysis and machine learning based characterization of single circulating tumor cells.<\/strong>
Iyer A, Gupta K, Sharma S, Hari K<\/span>, Lee YF, Ramalingam N, Yap YS, West J Bhagat AA, Subramani BV, Sabuwala B<\/span>, Tan TZ, Thiery JP, Jolly MK<\/strong>, Ramalingam N, Sengupta D (2020). Journal of Clinical Medicine, <\/em>9 (4): 1206<\/a><\/p>\n\n\n\n

Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology based approach.<\/strong>
Hari K, Sabuwala B, Subramani BV<\/span>, La Porta C, Zapperi S, Font-Clos F, Jolly MK#<\/sup> <\/strong>(2020). NPJ Systems Biology & Applications,<\/em> 6: 15<\/a><\/p>\n\n\n\n

Cancer Stem Cell plasticity \u2013 a deadly deal.<\/strong>
Archana PT*, Saxena K*<\/span>, Murali R, Jolly MK<\/strong>#<\/sup><\/em>, Nair R#<\/sup> (2020). Frontiers in Molecular Biosciences, <\/em>7:79<\/a><\/p>\n\n\n\n

Emergent properties of the HNF4\u03b1-PPAR\u03b3 network may drive consequent phenotypic plasticity in NAFLD.<\/strong>
Sahoo S*, Singh D*, Chakraborty P<\/span>, Jolly MK<\/strong>#<\/sup> (2020). Journal of Clinical Medicine, <\/em>9 (3): 870<\/a><\/p>\n\n\n\n

Decoding molecular interplay underlies the pulsatile IGF1R expression during acquisition of chemoresistance.<\/strong>
Dhadve AC, Hari K,<\/span> Rekhi B, Jolly MK<\/strong>, De A, Ray P (2020). BBA \u2013 Molecular Basis of Disease<\/em>, 1866 (1): 165754<\/a><\/p>\n\n\n\n

Comparative study of transcriptomics-based scoring metrics for the epithelial-hybrid-mesenchymal spectrum.<\/strong>
Chakraborty P<\/span>, George JT, Tripathi S, Levine H, Jolly MK<\/strong>#<\/sup> (2020). Frontiers in Bioengineering and Biotechnology, <\/em>8: 220<\/a><\/p>\n\n\n\n

ZEB1: a critical regulator of cell plasticity, DNA damage response and therapy resistance.<\/strong>
Drapela S, Bouchal J, Jolly MK<\/strong>, Culig Z, Soucek K (2020). Frontiers in Molecular BioSciences<\/em>, 10:3389<\/a><\/p>\n\n\n\n

A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells.<\/strong>
Tripathi S, Chakraborty P<\/span>, Levine H#<\/sup>, Jolly MK# <\/sup><\/strong>(2020). PLoS Computational Biology<\/em>, 16 (2): e1007619<\/a><\/p>\n\n\n\n

The Physics of Cellular Decision-Making during Epithelial-Mesenchymal Transition.<\/strong>
Tripathi S, Levine H#<\/sup>, Jolly MK<\/strong>#<\/sup><\/em> (2020). <\/em>Annual Reviews of Biophysics, <\/em>49: 1-18<\/a><\/p>\n\n\n\n

Differential contributions of pre- and post-EMT tumor cells in the breast to lung metastasis.<\/strong>
Lourenco AR, Ban Y, Crowley MJP, Lee S, Ramchandani D, Du W, Elemento O, George JT, Jolly MK<\/strong>, Levine H, Sheng J, Wong ST, Altorki NK, Gao D (2020). Cancer Research<\/em>, 80 (2): 163-169<\/a> (Featured in Cancer Research Highlights)<\/u><\/em><\/strong><\/p>\n\n\n\n

Histone deactylases, Mbd3\/NuRD and Tet2 hydroxylase are crucial regulators of epithelial-mesenchymal plasticity and tumor metastasis.<\/strong>
Kilinc AN, Kalathur RK, Sugiyama N, Antonaidis H, Birogul H, Ishay-Ronen D, George JT, Levine H, Jolly MK<\/strong>, Christofori G (2020). Oncogene<\/em>, 39: 1498-1513<\/a><\/p>\n<\/div><\/div>\n\n\n\n

\n

2019<\/span><\/h4>\n\n\n\n

Anticipating critical transitions in epithelial-hybrid-mesenchymal cell fate determination.<\/strong>
Sarkar S, Sinha SK#<\/sup>, Levine H#<\/sup>, Jolly MK<\/strong>#<\/sup><\/em>, Dutta PS#<\/sup> (2019). Proceedings of the National Academy of Sciences USA (PNAS), <\/em>116 (52): 26343-26352<\/a><\/p>\n\n\n\n

A CTC-cluster-specific signature derived from OMICS analysis of patient-derived xenograft tumors predicts outcomes in basal-like breast cancers.<\/strong>
Thangavel H, Angelis CD, Vasaikar S, Bhat R, Jolly MK<\/strong>, Nagi C, Creighton CJ, Chen F, Dobrolecki LE, George JT, Kumar T, Abdulkareem NM, Mao S, Nardone A, Rimawi M, Obsorne K, Lewis MT, Levine H, Zhang B, Schiff R, Giuliano M, Trivedi MV (2019). Journal of Clinical Medicine<\/em>, 8 (11): 1772<\/a><\/p>\n\n\n\n

Pericytes enable effective angiogenesis in the presence of pro-inflammatory signals. <\/strong>
Kang T, Bocci F, Jolly MK<\/strong>, Levine H, Onuchic JN, Levchenko A (2019). Proceedings of the National Academy of Sciences USA (PNAS), <\/em>116 (47): 23551-23561<\/a><\/p>\n\n\n\n

Phenotypic Switching of Na\u00efve T cells to Immune-suppressive Treg-like Cells by Mutant KRAS<\/strong>
Kalvala A, Wallet P, Yang L, Wang C, Li H, Nam A, Nathan A, Mambetsariev I, Poroyko V, Gao H, Chu P, Sattler M, Bild A, Manuel ER, Lee PP, Jolly MK<\/strong>, Kulkarni P, Salgia R. (2019). Journal of Clinical Medicine, <\/em>8 (10): 1726<\/a><\/p>\n\n\n\n

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis.<\/strong>
Celia-Terrassa T#<\/sup>, Jolly MK<\/strong>#<\/sup><\/em> (2019). Cold Spring Harb Perspect Med<\/em>, 10(7):a036905<\/a><\/p>\n\n\n\n

Dynamics of phenotypic heterogeneity associated with EMT and stemness during cancer progression.<\/strong>
Jolly MK<\/strong>#<\/sup><\/em>, Celia-Terrassa T#<\/sup> (2019). Journal of Clinical Medicine<\/em>, 8 (10): 1542<\/a><\/p>\n\n\n\n

A biophysical model uncovers the size distribution of circulating tumor cell clusters across cancer types.<\/strong>
Bocci F, Jolly MK<\/strong>#<\/sup><\/em>, Onuchic JN#<\/sup> (2019). Cancer Research<\/em>, 79 (21): 5527-5535<\/a><\/p>\n\n\n\n

Deciphering hydrodynamic and drug-resistant behaviors of metastatic EMT breast cancer cells moving in a constricted microcapillary.<\/strong>
Nath B, Bidkar AP, Kumar V, Dalal A, Jolly MK<\/strong>, Ghosh SS, Biswas G (2019). Journal of Clinical Medicine<\/em>, 8 (8): E1194<\/a><\/p>\n\n\n\n

Phenotypic heterogeneity in circulating tumor cells and its prognostic value in metastasis and overall survival.<\/strong>
Saxena K, Subbalakshmi A R<\/span>, Jolly MK<\/strong>#<\/sup><\/em> (2019). EBiomedicine<\/em>, 46: 4-5<\/a><\/p>\n\n\n\n

A possible role for epigenetic feedback regulation in the dynamics of the Epithelial-Mesenchymal Transition (EMT).<\/strong>
Jia W, Deshmukh A, Mani SA, Jolly MK<\/strong>#<\/sup><\/em>, Levine H#<\/sup>. (2019). Physical Biology<\/em>, 16 (6): 066004<\/a><\/p>\n\n\n\n

Acute vs. chronic vs. cyclic hypoxia: their differential dynamics, molecular mechanisms, and effects on tumor progression.<\/strong>
Saxena K<\/span>, Jolly MK<\/strong># <\/sup>(2019). Biomolecules, <\/em>9 (8): 339<\/a><\/p>\n\n\n\n

Small cell lung cancer therapeutic responses through fractal measurements: from radiology to mitochondrial biology.<\/strong>
Mambetsariav I, Mirzapoiazova T, Lennon F, Jolly MK<\/strong>, Li H, Nasser MW, Vora L, Kulkarni P, Batra SK, Salgia R (2019). Journal of Clinical Medicine<\/em>, 8 (7): E1038<\/a><\/p>\n\n\n\n

NRF2 inhibits a complete epithelial-mesenchymal transition and is maximally expressed in a hybrid epithelial\/mesenchymal phenotype.<\/strong>
Bocci F*,Tripathi SC*, Vilchez S*, George JT, Casabar JC, Wong PK, Hanash SM, Levine H#<\/sup><\/strong>, Onuchic JN#<\/sup><\/strong>, Jolly MK<\/strong>#<\/sup><\/em> (2019). Integrative Biology, <\/em>11 (6): 251-263<\/a><\/p>\n\n\n\n

Functional balance between Tcf21-Slug defines cellular plasticity and migratory modalities in high grade serous ovarian cancer cell lines.<\/strong>
Varankar S, More M, Ancy A, Pansare K, Kumar B, Narayanan NJ, Jolly MK<\/strong>, Mali AM, Bapat SA (2019). Carcinogenesis<\/em>, 41(4):515-526<\/a><\/p>\n\n\n\n

Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response.<\/strong>
Jia D, Li X, Bocci F, Tripathi S, Deng Y, Jolly MK<\/strong>#<\/sup><\/em>, Onuchic JN#<\/sup>, Levine H#<\/sup> (2019). Journal of Clinical Medicine, <\/em>8 (5): 725<\/a><\/p>\n\n\n\n

Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level.<\/strong>
Lin X, Kulkarni P#<\/sup>, Bocci F, Schafer N, Roy S, Tsai M-Y, He Y, Chen Y, Rajagopalan K, Mooney SM, Zeng Y, Weninger K, Grishaev A, Onuchic JN#<\/sup>, Levine H, Wolynes PG, Salgia R, Rangarajan G, Uversky V, Orban J#<\/sup>, Jolly MK<\/strong>#<\/sup><\/em> (2019). Biomolecules<\/em>, 9(2): E77<\/a><\/p>\n\n\n\n

An integrative systems biology and experimental approach identifies convergence of gene expression circuitry on alterations in epithelial plasticity, metabolism, and autophagy to promote chemoresistance.<\/strong>
Xu S, Ware KE, Ding Y, Kim SY, Sheth M, Chan W, Townsend J, Armstrong AJ, Eward WC, Jolly MK<\/strong>#<\/sup><\/em>, Somarelli JA#<\/sup>. (2019). Journal of Clinical Medicine, <\/em>8 (2): 205 (Cover article)<\/u><\/em><\/strong><\/a><\/p>\n\n\n\n

E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms.<\/strong>
Jolly MK<\/strong>*<\/em>, Ware KA*, Xu S, Gilja S, Shetler S, Yang Y, Wang X, Austin RG, Runyambo D, Hish AJ, Dewitt SB, George JT, Kruelen RT, Boss M-K, Lazarides AL, Kerr DL, Gerber DG, Sivaraj D, Armstrong AJ, Dewhirst MW, Eward WC, Levine H, Somarelli JA (2019). Molecular Cancer Research<\/em>, 17 (6): 1391-1402<\/a><\/p>\n\n\n\n

Spleen tyrosine kinase-mediated autophagy is required for epithelial-mesenchymal plasticity and metastasis in breast cancer.<\/strong>
Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK<\/strong>, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, Geahlen RL, Wendt MK (2019). Cancer Research<\/em>, 79 (8): 1832-1843 (Cover article)<\/u><\/em><\/strong><\/a><\/p>\n\n\n\n

The DNA walk and its demonstration of deterministic chaos \u2013 relevance to genomic alterations in lung cancer.<\/strong>
Hewelt B, Li H, Jolly MK<\/strong>, Kulkarni P, Mambetsariev I, Salgia R (2019). Bioinformatics<\/em>, 35 (16): 2738-2748<\/a><\/p>\n\n\n\n

Deciphering the dynamics of epithelial-hybrid-mesenchymal transition and cancer stem cells in tumor progression.<\/strong>
Bocci F, Levine H, Onuchic JN, Jolly MK#<\/sup><\/em>(2019). Current Stem Cell Reports, <\/em>5 (1): 11-21<\/a><\/p>\n\n\n\n

Computational modeling of the crosstalk between differently polarized macrophages and tumor cell plasticity in a tumor microenvironment.<\/strong>
Li X*, Jolly MK<\/strong>*<\/em>, George JT, Pienta KJ, Levine H (2019). Frontiers in Oncology<\/em>, 9: 10 <\/a><\/p>\n\n\n\n

Testing the gene expression classification of the EMT spectrum.<\/strong>
Jia D*, George JT*, Tripathi SC, Kundnani DL, Lu M, Hanash SM, Onuchic JN, Jolly MK<\/strong>#<\/sup><\/em>, Levine H#<\/sup> (2019). Physical Biology<\/em>, 16 (2): 025002<\/a><\/p>\n\n\n\n

Towards understanding cancer stem cell heterogeneity in the tumor microenvironment.<\/strong>
Bocci F*, Gearhart-Serna L*, Boareto M, Riberio M, Ben-Jacob E, Devi GR#<\/sup>, Levine H#<\/sup>, Onuchic JN#<\/sup>, Jolly MK<\/strong>#<\/sup> (2019). Proceedings of National Academy of Sciences USA (PNAS), <\/em>116 (1): 148-157<\/a><\/p>\n\n\n\n

Stability and mean residence times for hybrid epithelial\/mesenchymal phenotype.<\/strong>
Biswas K, Jolly MK<\/strong>#<\/sup>, Ghosh A#<\/sup> (2019). Physical Biology<\/em>, 16(2): 025003<\/a><\/p>\n\n\n\n

Hybrid epithelial\/mesenchymal phenotype promote metastasis and therapy resistance across carcinomas.<\/strong>
Jolly MK<\/strong>#<\/sup>, Somarelli JA, Sheth M, Biddle A, Tripathi SC, Hanash SM, Armstrong AJ, Bapat SA, Rangarajan A, Levine H#<\/sup> (2019). Pharmacology & Therapeutics, <\/em>194: 161-184<\/a><\/p>\n\n\n\n

2018<\/span><\/h4>\n\n\n\n

Chronic obstructive pulmonary disease (COPD) and lung cancer: underlying pathophysiology and new therapeutic modalities.<\/strong>
Eapen MS, Hansbro PM, CallerfeltA-K L, Jolly MK<\/strong>, MyersS, Sharma P, Markos J, Chia C, Larby J, Haug G, Hardikar A, Weber HC, Mabeza G, Cavalheri V, Khor YH, McDonald CF, Sohal SS (2018). Drugs<\/em>, 78 (16): 1717-1740 <\/a><\/p>\n\n\n\n

Regulation of epithelial-mesenchymal plasticity through interconnected feedback loops between ZEB1, ESRP1, HAS2, and CD44.<\/strong>
Jolly MK<\/strong>*, Preca BT*, Tripathi SC*, Jia D, George JT, Hanash SM, Brabletz T, Stemmler MP, Maurer J, Levine H (2018). APL Bioengineering<\/em>, 2 (3): 031908<\/a> (Among the \u2018Top cited articles in 2019\u2019)<\/u><\/em><\/p>\n\n\n\n

Hybrid epithelial\/mesenchymal phenotype(s): the \u2018fittest\u2019 phenotype(s) for metastasis?<\/strong>
Jolly MK<\/strong>, Mani SA, Levine H (2018). BBA Reviews on Cancer<\/em>, 1870 (2): 151-157<\/a><\/p>\n\n\n\n

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells, and Notch-Jagged signaling.<\/strong>
Bocci F, Jolly MK<\/strong>, George JT, Levine H, Onuchic JN (2018). Oncotarget<\/em>, 9 (52): 29906-29920 <\/a>(Highlighted in News & Views)<\/u><\/em><\/p>\n\n\n\n

Analysis of hierarchical organization in gene expression networks reveal underlying principles of collective tumor cell dissemination and metastatic aggressiveness of inflammatory breast cancer.<\/strong>
Tripathi S, Jolly MK<\/strong>, Woodward WA, Levine H, Deem MW (2018). Frontiers in Oncology<\/em>,8: 244<\/a><\/p>\n\n\n\n

Prostate-associated Gene 4 (PAGE4): leveraging the conformational dynamics of a dancing protein cloud as a therapeutic target.<\/strong>
Salgia R, Jolly MK<\/strong>, Dorff T, Lau C, Weninger K, Orban J, Kulkarni P (2018). Journal of Clinical Medicine<\/em>, 7 (6): 156<\/a><\/p>\n\n\n\n

PAGE4 and conformational switching: insights from molecular dynamics simulations and implications for prostate cancer.<\/strong>
Lin X, Roy S, Jolly MK<\/strong>, Bocci F, Schafer N, Tsai MY, Kulkarni P, Orban J, Grishaev A, Weninger K, Rangarajan G, Levine H, Onuchic JN (2018). Journal of Molecular Biology<\/em>, 430 (16): 2422-2438<\/a><\/p>\n\n\n\n

Phenotypic plasticity, bet-hedging, and androgen independence in prostate cancer: role of non-genetic heterogeneity.<\/strong>
Jolly MK<\/strong>, Kulkarni P, Weninger K, Orban J, Levine H (2018). Frontiers in Oncology<\/em>, 8: 50<\/a><\/p>\n\n\n\n

Crosstalk between MNK and XIAP mediates NFkB activity to promote a hyperproliferative breast cancer phenotype.<\/strong>
Evans MK, Brown M, Geradts J, Bao X, Robinson TJ, Jolly MK<\/strong>, Vermeulen PB, Palmer G, Gromeier M, Levine H, Morse MA, van Laere SJ, Devi GR (2018). Cancer Research<\/em>, <\/strong>78 (7): 1726-1738<\/a><\/p>\n\n\n\n

2017<\/span><\/h4>\n\n\n\n

Survival outcome in cancer patients predicted by a partial EMT gene expression scoring metric.<\/strong>
George JT*, Jolly MK<\/strong>*<\/em>, Xu S, Somarelli JA, Levine H (2017). Cancer Research<\/em>, 77 (22): 6415-6428<\/a> <\/p>\n\n\n\n

Numb inhibits a complete epithelial-mesenchymal transition by modulating Notch signaling<\/strong>
Bocci F*, Jolly MK<\/strong>*<\/em>, Tripathi SC*, Aguilar M, Hanash SM, Levine H, Onuchic JN (2017).Journal of the Royal Society Interface<\/em>,<\/strong> 14 (136): 20170512<\/a><\/p>\n\n\n\n

Inflammatory Breast Cancer: a model for investigating cluster-based dissemination.<\/strong>
Jolly MK<\/strong>#<\/sup><\/em>, Boareto M, Debeb B, Aceto N, Farach-Carson MC, Woodward WA, Levine H#<\/sup> (2017). NPJ Breast Cancer<\/em>, 3: 21<\/a><\/p>\n\n\n\n

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and its potential role in phenotypic heterogeneity.<\/strong>
Kulkarni P, Jolly MK<\/strong>, Jia D, Mooney SM, Bhargava A, Kagohara LT, Chen Y, Hao P, He Y, Veltri RW, Grishaev A, Weninger K, Levine H, Orban J (2017). Proceedings of the National Academy of Sciences USA (PNAS)<\/em>, 114(13): E2644-E2653<\/a> <\/p>\n\n\n\n

Operating principles of tristable circuits regulating cellular differentiation.<\/strong>
Jia D, Jolly MK<\/strong>, Harrison W, Boareto M, Ben-Jacob E, Levine H (2017). Physical Biology<\/em>, 14: 035007<\/a><\/p>\n\n\n\n

Distinguishing mechanisms underlying EMT Tristability.<\/strong>
Jia D, Jolly MK<\/strong>, Tripathi SC, Hollander DP, Huang B, Lu M, Celiktas M, Ramirez-Pena E, Ben-Jacob E, Onuchic JN, Hanash SM, Mani SA, Levine H (2017). Cancer Convergence<\/em>, 1:2<\/a><\/p>\n\n\n\n

Epithelial-mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?<\/strong>
Jolly MK<\/strong>, Tripathi SC, Somarelli JA, Hanash SM, Levine H (2017). Molecular Oncology<\/em>, 11 (7): 739-754<\/a><\/p>\n\n\n\n

EMT and MET: necessary or permissive for metastasis?<\/strong>
Jolly MK<\/strong>, Ware K, Gilja S, Somarelli JA, Levine H (2017). Molecular Oncology<\/em>, 11 (7): 755-769<\/a><\/p>\n\n\n\n

Epithelial mesenchymal transition (EMT), a spectrum of states: role in both lung development and disease.<\/strong>
Jolly MK<\/strong>, Ward C, Eapen MS, Myers S, Hallgren O, Levine H, Sohal S (2017). Developmental Dynamics<\/em>, 247 (3): 346-358<\/a><\/p>\n\n\n\n

Computational systems biology of epithelial-hybrid-mesenchymal transitions.<\/strong>
Jolly MK<\/strong>, Levine H (2017) Current Opinion in Systems Biology<\/em>, 3: 1-6<\/a><\/p>\n\n\n\n

Phenotypic plasticity and cell-fate `decisions in cancer: insights from dynamical systems theory.<\/strong>
Jia D, Jolly MK<\/strong>, Kulkarni P, Levine H (2017). Cancers<\/em>, 9 (7): 70<\/a><\/p>\n\n\n\n

GRHL2\/ZEB feedback loop \u2013 a key axis in the regulation of EMT in breast cancer.<\/strong>
Mooney SM*, Talebian V*, Jolly MK<\/strong>*, Jia D*, Gromala M, Levine H, McConkey BJ (2017). Journal of Cellular Biochemistry<\/em>, 118 (9): 2559-2570<\/a><\/p>\n\n\n\n

MCAM mediates chemoresistance in small cell lung cancer via PI3K\/AKT\/SOX2 Signaling Pathway.<\/strong>
Tripathi SC, Fahrmann JF, Celiktas M, Aguilar M, Marini KM, Jolly MK<\/strong>, Katayama H, Wang H, Murage EN, Dennison JB, Watkins N, Levine H, Ostrin EJ, Taguchi A, Hanash SM (2017). Cancer Research<\/em>, 77 (16): 4414-4425<\/a><\/p>\n\n\n\n

Induction of mesenchymal-epithelial transitions in sarcoma cells.<\/strong>
Ware KE, Gilja S, Xu S, Shetler S, Jolly MK<\/strong>, Wang X, Bartholf-Dewitt S, Hish AJ, Jordan S, Eward W, Levine H, Armstrong AJ, Somarelli JA (2017). Journal of Visualized Experiments, <\/em>112<\/a><\/p>\n\n\n\n

2016<\/span><\/h4>\n\n\n\n

Mesenchymal-epithelial transition in sarcomas is controlled by the combinatorial expression of GRHL2 and miR-200s.<\/strong>
Somarelli JA, Shelter S, Jolly MK<\/strong>, Wang S, Bartholf-Dewitt S, Hish A, Gilja S, Eward W, Ware K, Levine H, Armstrong AJ, Garcia-Blanco MA (2016). Molecular and Cellular Biology<\/em>, 36 (19): 2503-2513 <\/a>(Cover article)<\/u><\/em><\/strong><\/p>\n\n\n\n

Notch -Jagged signaling can give rise to clusters of cells exhibiting a hybrid epithelial\/mesenchymal phenotype.<\/strong>
Boareto M, Jolly MK<\/strong>, Goldman A, Pietila M, Mani SA, Sengupta S, Ben-Jacob E, Levine H, Onuchic JN (2016). Journal of the Royal Society Interface<\/em>, 13 (118): 20151106<\/a> <\/p>\n\n\n\n

Stability of the hybrid epithelial \/mesenchymal phenotype.<\/strong>
Jolly MK<\/strong>,<\/em> Tripathi SC, Jia D, Mooney SM, Celiktas M, Mani SA, Hanash S, Pienta KJ, Ben-Jacob E, Levine H (2016). Oncotarget<\/em>, 7 (19): 27067-27084<\/a><\/p>\n\n\n\n

Immuno-proteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome.<\/strong>
Tripathi SC, Peters HL, Taguchi A, Katayama H, Wang H, Momin A, Jolly MK<\/strong>, Celiktas M, Rodriguez-Canales J, Liu H, Behrens C, Wistuba II, Ben-Jacob E, Levine H, Molldrem JJ, Hanash SM, Ostrin EJ (2016). Proceedings of the National Academy of Sciences USA (PNAS)<\/em>, 113 (11): E1555-1564<\/a><\/p>\n\n\n\n

Phenotypic plasticity in prostate cancer: the role of intrinsically disordered proteins.<\/strong>
Mooney SM, Jolly MK<\/strong>, Levine H, Kulkarni P (2016). Asian Journal of Andrology<\/em>, 18 (5): 704-710<\/a><\/p>\n\n\n\n

Tumor budding: the name is EMT. Partial EMT.<\/strong>
Grigore AD*, Jolly MK<\/strong>*<\/em>, Jia D, Farach-Carson MC, Levine H (2016). Journal of Clinical Medicine<\/em>, 5(5): E51<\/a><\/p>\n\n\n\n

2015<\/span><\/h4>\n\n\n\n

Modeling the transitions between collective and solitary migration phenotypes in cancer metastasis.<\/strong>
Huang B, Jolly MK<\/strong>, Lu M, Tsarfaty I, Ben-Jacob E, Onuchic JN (2015). Scientific Reports<\/em>, 5: 17379 <\/a>(Recommended by F1000 faculty)<\/u><\/em><\/p>\n\n\n\n

Jagged mediates differences in normal and tumor angio-genesis by affecting tip-stalk fate decision.<\/strong>
Boareto M, Jolly MK<\/strong>, Ben-Jacob E, Onuchic JN (2015). Proceedings of the National Academy of Sciences USA (PNAS)<\/em>, <\/strong>112 (29): E3836-E3844<\/a><\/p>\n\n\n\n

Coupling the modules of EMT and stemness: A tunable \u2018stemness window\u2019 model.<\/strong>
Jolly MK<\/strong>*<\/em>, Jia D*, Boareto M, Mani SA, Pienta KJ, Ben-Jacob E, Levine H (2015). Oncotarget<\/em>, <\/strong>6(28): 25161-25174<\/a><\/p>\n\n\n\n

Operating principles of Notch-Delta-Jagged module of cell-cell communication.<\/strong>
Jolly MK<\/strong>*<\/em>, Boareto M*, Lu M, Clementi C, Onuchic JN, Ben-Jacob E (2015). New Journal of Physics, <\/em>17: 055021<\/a><\/p>\n\n\n\n

OVOL guides the epithelial-hybrid-mesenchymal transition.<\/strong>
Jia D*, Jolly MK<\/strong>*<\/em>, Boareto M, Parsana P, Mooney SM, Pienta KJ, Levine H, Ben-Jacob E (2015). Oncotarget, <\/em>6 (17): 15436-15448<\/a><\/p>\n\n\n\n

Implications of the hybrid epithelial\/mesenchymal phenotype in metastasis.<\/strong>
Jolly MK<\/strong>, Boareto M, Huang B, Jia D, Lu M, Onuchic JN, Ben-Jacob E, Levine H (2015). Frontiers in Oncology<\/em>,5: 155<\/a><\/p>\n\n\n\n

Jagged-Delta Asymmetry in Notch Signaling can give rise to a Sender\/Receiver hybrid phenotype.<\/strong>
Boareto M, Jolly MK<\/strong>, Lu M, Onuchic JN, Clementi C, Ben-Jacob E (2015). Proceedings of the National Academy of Sciences USA (PNAS)<\/em>, 112(5): E402-E409<\/a><\/p>\n\n\n\n

2014<\/span><\/h4>\n\n\n\n

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness.<\/strong>
Jolly MK<\/strong>, Huang B, Lu M, Mani SA, Levine H, Ben-Jacob E (2014). Journal of the Royal Society Interface<\/em>, 11 (101): 20140962 <\/a> (Highlighted in National Science Foundation (NSF) News)<\/u><\/em><\/p>\n\n\n\n

The three-way switch operation of Rac1\/ RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition.<\/strong>
Huang B, Lu M, Jolly MK<\/strong>, Tsarfaty I, Onuchic JN, Ben-Jacob E (2014). Scientific Reports<\/em>4: 6449<\/a><\/p>\n\n\n\n

Toward Decoding the Principles of Cancer Metastasis Circuits.<\/strong>
Lu M*<\/strong>, Jolly MK*<\/strong>, Onuchic JN, Ben-Jacob E (2014). Cancer Research, <\/strong><\/em>74 (17): 4574-4587<\/a><\/p>\n\n\n\n

Mathematical modeling of sub-cellular asymmetry of Fat-Dachsous Heterodimer for generation of Planar Cell Polarity.<\/strong>
Jolly MK<\/strong>*,#<\/sup><\/em>, Rizvi MS*, Kumar A, Sinha P (2014). PLoS ONE<\/em>9(5): e97641<\/a><\/p>\n\n\n\n

2013<\/span><\/h4>\n\n\n\n

MicroRNA-based regulation of epithelial-hybrid-mesenchymal cell fate determination.<\/strong>
Lu M*<\/strong>, Jolly MK<\/strong>*<\/em>, Levine H, Onuchic JN, Ben-Jacob E (2013). Proceedings of the National Academy of Sciences USA (PNAS)<\/em>, <\/strong>110(45): 18144-18149<\/a><\/p>\n\n\n\n

Tristability in Cancer Associated miRNA-TF Chimera Toggle Switch.<\/strong>
Lu M, Jolly MK<\/strong>, Gomoto R, Huang B, Onuchic JN, Ben-Jacob E (2013). Journal of Physical Chemistry B<\/em>, <\/strong>117(42): 13164-13174<\/a> <\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

For the latest updates, please visit Google Scholar (Total citations: 14,000+; h-index= 65) *Equal contribution, #Corresponding author; Members from the group are underlined Peer-Reviewed Articles 2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | Pre – 2019 2026 Repurposing statins in combination therapy for effective ablation of metastatic breast cancer.Aara R,Continue reading “Publications”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-60","page","type-page","status-publish","hentry","entry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/pages\/60","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/comments?post=60"}],"version-history":[{"count":190,"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/pages\/60\/revisions"}],"predecessor-version":[{"id":2317,"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/pages\/60\/revisions\/2317"}],"wp:attachment":[{"href":"https:\/\/be.iisc.ac.in\/~mkjolly\/wp-json\/wp\/v2\/media?parent=60"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}