The Drug Delivery Lab

Publications

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• Dhanabalan K.M.; Padhan B.; Dravid A.A.; Agarwal S.; Pancheri N.M.; Lin A.; Willet N.J.; Padmanabhan A.K., Agarwal R., Nordihydroguaiaretic acid microparticles are effective in the treatment of osteoarthritis. Submitted.

• Jeyasankar S.; Kalapala Y.C.; Sharma P.R.; Agarwal R., Antibacterial efficacy of mycobacteriophages against virulent Mycobacterium tuberculosis. BMC Microbiology 24 (2024) 320. Also check out a short video summary of the paper by the authors. Video link.

• Gupta V.K.; Vijaya V.V.; Suresh A.P.; Arrieta M.L.; Konkada J.M.; Jeyasankar S.; Raghunathan V.; Baliga N.S.; Agarwal R., 3-dimensional hydrogel culture system recapitulates key tuberculosis phenotypes and demonstrates pyrazinamide efficacy. BioRxiv. Advanced Healthcare Materials (2024) 2304299. Also check out a short video summary of the paper by the authors. Video link. Read coverage by IISc

• Shah D.; Sharma P.S.; Agarwal R.; Barik A., A septo-hypothalamic-medullary circuit directs stress-induced analgesia. BioRxiv. eLife 13 (2024) RP96724.

• Choudhary B.S.; Kumar A.; Vashistha A.; Tejashri S.; Kumar A.S.; Agarwal R.; Chakrapani H. An esterase-cleavable persulfide donor with no electrophilic byproducts and a fluorescence reporter. Chemical Communications 60 (2024) 1727.

• Narayan R.; Sharma M.; Yadav R.; Biji A.; Khatun O.; Kaur S.; Kanojia A.; Joy C.M.; Rajmani R.; Sharma P.R.; Jeyasankar S.; Rani P.; Shandil R.K.; Narayanan S.; Rao D.C.; Satchidanandanam V.; Das S.; Agarwal R.; Tripathi S., Picolinic acid is a broad-spectrum inhibitor of enveloped virus entry that restricts SARS-CoV-2 and Influenza A virus in vivo. Cell Reports Medicine 4 (2023) 101127. BioRxiv. Read coverage by Deccan Herald.

• Dravid A.A.; Dhanabalan K.M.; Naskar S.; Vashistha A.; Agarwal S.; Padhan B.; Dewani M.; Agarwal R., Sustained release resolvin D1 liposomes are effective in the treatment of Osteoarthritis in obese mice. Journal of Biomedical Materials Research Part A 111 (2023) 765. BioRxiv. Also check out a short video summary of the paper by the authors. Video link.

• Dhanabalan K.M.; Dravid A.A.; Agarwal S.; Sharath R.K.; Padmanabhan A.K., Agarwal R., Intra-articular Injection of Rapamycin Microparticles Prevent Senescence and Effectively Treat Osteoarthritis. Bioengineering and Translational Medicine 8 (2023) e10298. BioRxiv. Also check out a short video summary of the paper by the authors. Video link.
• George E.; Goswami A.; Lodhiya, T.; Padwal P.; Iyer S.; Gauttam I.; Sethi L.; Jeyasankar S.; Sharma P.S.; Mukherjee R.; Agarwal R., Immunomodulatory effect of mycobacterial outer membrane vesicles coated nanoparticles. Biomaterials Advances 139 (2022) 213003. BioRxiv. Also check out a short video summary of the paper by the authors. Video link.
  This article was covered by several organizations. Read coverage by IISc, BioSpectrum, The New Indian Express, Hindu, India Today,and Phys.org.
• Sharma P.R.; Dravid A.A.; Kalapala Y.C.; Gupta V.K.; Jeyasankar S.; Goswami A.; Agarwal R., Cationic inhalable particles for enhanced drug delivery to Mycobacterium tuberculosis infected macrophages. Biomaterials Advances 133 (2022) 112612. BioRxiv. Also check out a short video summary of the paper by the authors. Video link.
• Dravid A.A.; Dhanabalan K.M.; Agarwal S.; Agarwal R., Resolvin D1-loaded nanoliposomes promote M2 macrophage polarization and are effective in treatment of Osteoarthritis. Bioengineering and Translational Medicine 7 (2022) e10281. Also check out a short video summary of the paper by the authors. Video link.
• Iyer S.; Yadav R.; Agarwal S.; Tripathi S.; Agarwal R., Bioengineering Strategies for Developing Vaccines Against Respiratory Viral Diseases. Clinical Microbiology Reviews 35 (2022) e00123-21.
• Goswami A.; Sharma P.R.; Agarwal R., Combatting intracellular pathogens using bacteriophage delivery. Critical Reviews in Microbiology 47 (2021) 1-18
• Kalapala Y.C.; Sharma P.R.; Agarwal R., Antimycobacterial potential of Mycobacteriophage under disease-mimicking conditions. Frontiers in Microbiology 11 (2020) 583661.
  This article was covered by several organizations. Read coverage by IISc, interview at BioPatrika, coverage by Research Matters, coverage by Rajasthan Patrika, and coverage by IndiaBioscience
• Dhanabalan K.M.; Gupta V.K.; Agarwal, R., Rapamycin-PLGA microparticles prevent senescence, sustain cartilage matrix production under stress and exhibit prolonged retention in mice joints. Biomaterials Science 8 (2020) 4308 – 4321.
  This article was covered by several organizations. Read coverage by IISc, coverage by Hindu, coverage by News18, coverage by Bangalore Mirror, and coverage by Rajasthan Patrika
• Quiros M.; Feier D.; Birkl D.; Agarwal, R.; Zhou D.W.; Garcia A.J.; Parkos C.A.; Nusrat A., Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing. Proceedings of the National Academy of Sciences USA 117 (2020) 9477-9482.
• Agarwal, R.; Johnson C.T.; Imhoff B.R.; Donlan R.M.; McCarty, N.A.; García A.J., Inhaled bacteriophage-polymeric particles ameliorate lung cystic fibrosis infections. Nature Biomedical Engineering 2 (2018) 841-849. Behind the paper story: Using bacteriophage virus to tackle bacterial lung infections.
• Johnson C.T.; Wroe J.A.; Agarwal R.; Martin K.E.; Guldberg, R.E.; Donlan R.M.; Westblade L.F.; García A.J., Hydrogel delivery of lysostaphin eliminates orthopaedic implant infection by Staphylococcus aureus and supports fracture healing. Proceedings of the National Academy of Sciences USA 115 (2018) E4960-E4969.
• Alas G.R*.; Agarwal R*.; Collard D.M.; García A.J., Peptide-functionalized poly[oligo(ethylene glycol) methacrylate] brushes on dopamine-coated stainless steel for controlled cell adhesion. Acta Biomaterialia 59 (2017) 108-116. (*= equal contribution).
• Jurney, P.; Agarwal, R.; Singh, V.; Choi, D.; Roy, K.; Sreenivasan, S.V.; Shi, L., Unique size and shape-dependent uptake behaviors of non-spherical nanoparticles by endothelial cells due to a shearing flow. Journal of Controlled Release 245 (2016) 170-176.
• Agarwal, R.; Volkmer, T.M*.; Wang P.; Lee A.; Wang Q.; García A.J., Synthesis of self-assembled IL-1Ra-presenting nanoparticles for the treatment of osteoarthritis. Journal of Biomedical Materials Research Part A 104 (2015) 595-599 (*= equal contribution).
• Jurney, P.; Agarwal, R.; Roy, K.; Sreenivasan, S.V.; Shi, L., Size-Dependent Nanoparticle Uptake by Endothelial Cells in a Capillary Flow System. Journal of Nanotechnology in Engineering and Medicine 6 (2015) 011007-011013.
• Agarwal, R.; Jurney, P.; Raythatha, M.; Singh, V.; Sreenivasan, S.V.; Shi, L.; Roy, K., Effect of Shape, Size, and Aspect Ratio on Nanoparticle Penetration and Distribution inside Solid Tissues Using 3D Spheroid Models. Advanced Healthcare Materials 4 (2015) 2269-2280.
• Agarwal, R.; González-García, C.; Torstrick, B.; Guldberg, R.E.; Salmeron-Sanchez, M.; García A.J., Simple coating with fibronectin fragments enhances stainless steel screw osseointegration in healthy and osteoporotic rats. Biomaterials 63 (2015) 137-145.
• Agarwal, R.; García A.J., Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair. Advanced Drug Delivery Reviews 94 (2015) 53-62.
• Singh, V.; Agarwal, R.; Marshall K.; Jurney, P.; Roy K.; Shi, L.; Sreenivasan, S.V., Scalable Fabrication of Ultra-Soft Shape Specific Nanocarriers for Diagnostics and Drug Delivery Journal of Micro and Nano-manufacturing. 3 (2015) 011002-011010.
• Singh A.; Agarwal, R.; Diaz C.; Willett N.J.; Wang P.; Lee A.; Wang Q.; Guldberg R.E.; García A.J., Nanoengineered Particles for Enhanced Intra-Articular Retention and Delivery of Proteins. Advanced Healthcare Materials 3 (2014) 1562-1567.
• Agarwal, R.; Singh, V.; Jurney, P.; Shi, L.; Sreenivasan, S.V.; Roy, K., Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms. Proceedings of the National Academy of Sciences USA 110 (2013) 17247-17252.
• Agarwal, R.; Roy, K., Intracellular delivery of polymeric nanocarriers: a matter of size, shape, charge, elasticity and surface composition. Therapeutic Delivery 4 (2013) 705-723.
• Jurney, P.; Agarwal, R.; Singh, V.; Roy, K.; Sreenivasan, S.V.; Shi, L., Size-Dependent Nanoparticle Margination and Adhesion Propensity in a Microchannel. Journal of Nanotechnology in Engineering and Medicine 4 (2013) 031002-031009.
• Agarwal, R.; Singh, V.; Jurney, P.; Shi, L.; Sreenivasan, S.V.; Roy, K., Scalable Imprinting of Shape-Specific Polymeric Nanocarriers Using a Release Layer of Switchable Water Solubility. ACS Nano 6 (2012) 2524-2531.
• Mukherjee S.; Maity S.; Roy S.; Ghorai S.; Chakrabarti M.; Agarwal, R.; Dutta D.; Ghosh A.K.; Das A.K., Cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of glyceraldehyde-3-phosphate dehydrogenase from Antheraea mylitta. Acta Crystallographica Section Fs 65 (2009) 937-940.