Summer Training Program at Param Hansa Centre for Computational Oncology
Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma. Pillai M, Jolly MK (2021). iScience, 24: 103111 
Multistability in cellular differentiation enabled by a network of three mutually repressing master regulators. Duddu AS, Sahoo S, Hati S, Jhunjhunwala S, Jolly MK (2020). Journal of the Royal Society Interface, 17 (170): 20200631 
A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells. Sahoo S, Mishra A, Kaur H, Hari K, Muralidharan S, Mandal S, Jolly MK (2021). NAR Cancer, 3 (3): zcab027 
Landscape of epithelial mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks. Hari K, Ullanat U, Balasubramanian A, Gopalan A, Jolly MK (2022). eLife 11:e76535. 
Functional resilience of mutually repressing motifs embedded in larger regulatory networks Harlapur P, Duddu AS, Hari K, Jolly MK (2021) bioRxiv:475824 
Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity during helper T-cell differentiation. Duddu AS, Jhunjhunwala S, Jolly MK (2021). Mol Biol Cell 33(6):ar46. 
Interconnected high-dimensional landscapes of epithelial-mesenchymal plasticity and stemness. Sahoo S, Ashraf B, Duddu AS, Biddle A, Jolly MK (2022). Clin Exp Metastasis 39(2):279-290 
Interconnected high-dimensional landscapes of epithelial-mesenchymal plasticity and stemness. Sahoo S, Ashraf B, Duddu AS, Biddle A, Jolly MK (2022). Clin Exp Metastasis 39(2):279-290 
Interconnected high-dimensional landscapes of epithelial-mesenchymal plasticity and stemness. Sahoo S, Ashraf B, Duddu AS, Biddle A, Jolly MK (2022). Clin Exp Metastasis 39(2):279-290 
Cancer: more than a geneticist’s Pandora’s box. Saxena K, Subbalakshmi AR, Kulkarni P, Jolly MK (2022). J Biosci 47, 21 (2022) 
Emergence of planar cell polarity from the interplay of asymmetric interaction and tissue-level gradients. Singh D, Jolly MK, Rizvi MS (2021). bioRxiv: 468750 
Book Chapters and Journal Cover Page 
Emergent properties of the HNF4α-PPARγ network may drive consequent phenotypic plasticity in NAFLD. Sahoo S Singh D, Chakraborty P, Jolly MK (2020). Journal of Clinical Medicine, 9 (3): 870
Cancer metastasis and therapy resistance remain unsolved clinical challenges and cause almost all fatalities due to cancer. Our long-term goal is to design more effective therapeutic strategies that can prevent metastasis and therapy resistance, using a network-level and dynamic understanding of the molecular mechanisms gained through an interdisciplinary systems biology approach.
Our research interests are at the intersection of cancer biology and computational systems biology. Working closely with experimental collaborators, we develop predictive mechanism-based multi-scale mathematical models to elucidate the emergent dynamics of cellular networks driving metastasis and drug resistance.
Interested in joining the lab? Contact us.