Preprints

Preprints

Early Detection of Sudden Transitions in Notch signaling.
Tikader B, Sarkar S, Sinha SK, Levine H,Jolly MK, Dutta PS (2026). bioRxiv:703083

Decoupling of spatial scales in breast pathology reveals fractal-like nuclear organization emergent from tissue spatial architecture.
Das A, Ahammer H, Prabhu JS, Bhat R, Jolly MK (2026). MedRxiv:26352267

Interplay Between Immune Checkpoint Modulators and the Epithelial-to-Mesenchymal Transition Axis in Clear Cell Renal Cell Carcinoma.
Poddar A, Nield FA, Sharma R, Subhadarshini S, Jolly MK, Ramakrishna S, Raza A, Shukla R, Kannourakis G, Jayachandran A, Prithviraj P (2026).Preprints:202604.213

Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC.
Vashista S, Meena RK, Kulkarni P, Salgia R, Thomas A, Jolly MK (2026). bioRxiv: 719547

Time-dependent memory of hypoxia exposure influences tumor invasion dynamics.
Sadhu G, Jain P, Meena RK, George JT, Jolly MK (2026). bioRxiv: 716866

A Single Equation Explains Go-or-Grow Dynamics in Cyclic Hypoxia.
Sadhu G, Maini PK, Jolly MK. arxiv: 23042

Traveling Wave Analysis of a Go-or-Grow Invasion Model with ECM-Regulated Phenotypic Switching.
Sadhu G, Jolly MK, Maini PK. bioRxiv: 720361

Multi-team conflict resolution is ineffective for stable decision making.
Haldar K, Anand V, Moger A, Gedeon T, Hari KJolly MK (2025). bioRxiv: 679762

A phenotype-structured PDE framework for investigating the role of hypoxic memory on tumor invasion under cyclic hypoxia.
Sadhu G, Jain P, George JT, Jolly MK (2025). bioRxiv: 684650

Interconnected axes of phenotypic plasticity drive coordinated cellular behaviour and worse clinical outcomes in breast cancer.
Meena RK, Fan Y, Soundharya R, Pandey AJ, Kannan A, Subramanian Y, Subramanian Y, George JT, Jolly MK (2025). bioRxiv: 688595

Regulatory network and spatial modeling reveal cooperative mechanisms of resistance and immune escape in ER+ breast cancer.
Yijia Fan, Sahoo S, Jolly MK, George JT (2025). bioRxiv: 679692

Multi-omics investigation reveals molecular determinants of cancer cell evolution on soft extracellular matrix.
Sahoo S, Khanna S, Wang TC, Lele TP, Jolly MK (2025). bioRxiv: 694784

Distinct geometrical landscapes distinguish between modes of tristability in gene regulatory networks.
Duddu ASJolly MK, Raju A (2025). bioRxiv: 681792

Fixed points and multistability in monotone Boolean network models.
Adigwe S, BV HarshavardhanJolly MK, Tomáš Gedeon (2025). bioRxiv: 682751

ONCOchannelome: A computational framework for investigating altered ion channels across tumor types.
Parthasarathi KTS, Soundharya RJolly MK, Jyoti Sharma (2025). bioRxiv: 685767

How memory and adaptation cost shape cell phenotypic dynamics in response to fluctuating environments.
Jain PJolly MK#, George JT# (2025). bioRxiv: 655868

Balance between autophagy and apoptosis determines anoikis resistance: a mathematical model on cell fate.
Maiti S, Chedere A, Jolly MK, Chandra N, Rangarajan A (2025). bioRxiv: 658583

Multiscale modeling predicts dependence of mesenchymally transitioned tumor niche fitness on cell-cell and cell-matrix adhesions.
Prasanna CVSJolly MK#, Bhat R# (2025). bioRxiv: 661486

Gain of Function p53 mutant R273H confers distinct methylation profiles and consequent partial or full EMT states to colon tumour.
Rani H, Subhadarshini SJolly MK, Mahadevan V (2025). bioRxiv: 662954

Collective amoeboid dynamics drives colonization of drug-resistant ovarian cancer cells.
Goutham S, Gopikrishnan A, BV Harshavardhan, Venas N, Sabarinathan RK, Jolly MK, Bhat R (2024). bioRxiv: 616763

Mechano-sensing role of oncogenic lncRNA NEAT1 on soft vs. stiff substrates and its implications for glioblastoma progression.
Ghosh A, Soundharya R, Jolly MK, Majumder A (2024). bioRxiv: 624463

Cell-autonomous BMP signaling plays a key role in the maintenance of tumour cell EMT and migration programs in human ovarian carcinoma.
Joun G, Zolghadr F, Chakraborty P, Yen LLT, Chong JJH, Bowtell D, DeFazio A, Jolly MK, Seyedasli N (2023). bioRxiv: 538847

Mechanistic modeling of the SARS-CoV-2 and immune system interplay unravels design principles for diverse clinicopathological outcomes.
Sahoo S, Hari K, Jhunjhunwala S#, Jolly MK# (2020). bioRxiv: 097238

AMPK-Fyn signaling promotes Notch1 stability to potentiate hypoxia-induced breast cancer stemness and drug resistance.
Lahiry M, Kumar S, Hari K, Chedere A, Jolly MK#, Rangarajan A# (2020). bioRxiv: 458489