I am a PhD student in the lab. I received my Masters in Biotechnology from Indian Institute of Technology, Bombay, where I worked with Prof. Ranjith Padinhateeri and Prof. Jayadeva Bhatt in understanding the role of stochastic processes in the GAL system of yeast. Inspired by the ability of biological systems to show deterministic behaviour despite the omnipresent stochastic heterogeneity, I got interested in understanding the mechanisms underlying heterogeneity in cancer. In my PhD, I am investigating an aspect of the heterogeneity called Epithelial-Mesenchymal Plasticity, a developmental process with significant implications for cancer metastasis. Using network modelling and population data analysis, I am trying to answer the question of how deterministic and stochastic mechanisms of population heterogeneity interact with each other and possibly lead to improved survival.
In my free time, I like to sing, play violin and code.
My recent publications:
- Hari, K., Sabuwala, B., Subramani, B.V. et al. Identifying inhibitors of epithelial–mesenchymal plasticity using a network topology-based approach. npj Syst Biol Appl 6, 15 (2020). DOI
- Dhadve A.C., Hari K., Rekhi B. et. al. Decoding molecular interplay between RUNX1 and FOXO3a underlying the pulsatile IGF1R expression during acquirement of chemoresistance. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1886, 6 (2020). DOI
- Sahoo S., Hari K., Jhunjhunwaala S. and Jolly M.K., Mechanistic modeling of the SARS-CoV-2 and immune system interplay unravels design principles for diverse clinicopathological outcomes. biorxiv (2020). DOI