Cancer metastasis and therapy resistance remain unsolved clinical challenges and cause almost all fatalities due to cancer. Our long-term goal is to design more effective therapeutic strategies that can prevent metastasis and therapy resistance, using a network-level and dynamic understanding of the molecular mechanisms gained through an interdisciplinary systems biology approach.
Our research interests are at the intersection of cancer biology and computational systems biology. Working closely with experimental collaborators, we develop predictive mechanism-based multi-scale mathematical models to elucidate the emergent dynamics of cellular networks driving metastasis and drug resistance.
Interested in joining the lab? Contact us.
Latest Publications
Singh D, Bocci F, Kulkarni P, Jolly MK# (2020). Coupled feedback loops involving PAGE4, EMT and Notch signaling can give rise to non-genetic heterogeneity in prostate cancer cells. Entropy 2021, 23 (3), 288
Bocci F#, Mandal S, Tejaswi T, Jolly MK# (2020). Investigating epithelial-mesenchymal heterogeneity of tumors and circulating tumor cells with transcriptomic analysis and biophysical modeling. Computational and Systems Oncology 2.1015
Chakraborty P, George JT, Woodward W, Levine H, Jolly MK# (2021). Gene expression profiling of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum.Translational Oncology, 14 (4): 101026
Chedere A, Hari K, Kumar S, Rangarajan A#, Jolly MK# (2021). Multistability and consequent phenotypic plasticity in AMPK-Akt double negative feedback loop in cancer cells. Journal of Clinical Medicine, 10 (3): 472
Pasani S, Sahoo S, Jolly MK# (2021). Hybrid E/M phenotype(s) and stemness: a mechanistic connection embedded in network topology. Journal of Clinical Medicine, 10(1): 60
Subbalakshmi A R, Sahoo S, Biswas K, Jolly MK# (2020). A computational systems biology approach identifies SLUG as a mediator of partial Epithelial-Mesenchymal Transition. Cells Tissues Organs, in press (bioRxiv: 278085)
Sahoo S, Jhunjhunwala S, Jolly MK#(2020). The Good, The Bad and The Ugly: A mathematical model investigates the differing outcomes among CoVID-19 patients. Journal of the Indian Institute of Science, in press
Duddu AS, Sahoo S, Hati S, Jhunjhunwala S, Jolly MK# (2020). Multistability in cellular differentiation enabled by a network of three mutually repressing master regulators. Journal of the Royal Society Interface, 17 (170): 20200631
Saxena K, Srikrishnan S, Celia-Terrassa T, Jolly MK# (2020). OVOL1/2: Drivers of epithelial differentiation in development, disease and reprogramming. Cells Tissues Organs, in press (Preprints: 2020070713)
Subbalakshmi A R, Kundnani D, Biswas K, Hanash SM, Ghosh A, Tripathi SC#, Jolly MK# (2020). NFATc acts as a non-canonical phenotypic stability factor for a hybrid epithelial/mesenchymal phenotype. Frontiers in Oncology, 10: 553342
Saxena K, Jolly MK#, Balamurugan K# (2020). Hypoxia, partial EMT and collective migration: emerging culprits in metastasis. Translational Oncology, 13 (11): 100845
Hari K, Sabuwala B, Subramani BV, La Porta C, Zapperi S, Font-Clos F, Jolly MK# (2020). Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology based approach. NPJ Systems Biology & Applications, 6: 15
Sahoo S*, Singh D*, Chakraborty P, Jolly MK# (2020). Emergent properties of the HNF4α-PPARγ network may drive consequent phenotypic plasticity in NAFLD. Journal of Clinical Medicine, 9 (3): 870
Chakraborty P, George JT, Tripathi S, Levine H, Jolly MK# (2020). Comparative study of transcriptomics-based scoring metrics for the epithelial-hybrid-mesenchymal spectrum. Frontiers in Bioengineering and Biotechnology, 8: 220
Latest News
Divyoj attended APS March 2021 meeting and presented his work on coupling mutistable and oscillatory circuits which got published in Entropy.
Mubasher joined as a Post-doc fellow, Welcome Mubasher!
Mahesh joined as a PhD Stdent, Welcome Mahesh!
Ushasi joined as Post-doc fellow, Welcome Ushasi!
Mohit is invited to be an Associate Editor on the new journal by Wiley Publishers, Computational and Systems Oncology. Congratulations Mohit!
Mohit selected as Infosys Young Investigator. Congratulations Mohit!
Shuba passes her qualifying exam. Congratulations Shuba!
Atchuta gets awarded the the prestigious Prime Minister’s Research Fellowship (PMRF). Congratulations Atchuta!
Shuba wins the first runner-up poster award at the International Poster Presentation Competition – IPCC 2020. Congratulations Shuba!
Mohit and Rik Thompson (QUT, Australia) organize a webinar course on ‘Modeling and Measuring the epithelial/mesenchymal plasticity (EMP)’.
Sarthak attends a keynote symposium on ‘Tissue Plasticity: Preservation and Alteration of Cellular Identity‘
Sarthak’s review article on Mathematical modeling of COVID-19 is published in Journal of IISc. Congratulations Sarthak!
Paras and Prasanna join the group as PhD students. Welcome Paras and Prasanna!
Mohit joins as Adjunct Faculty, School of Biomedical Sciences, Queensland University of Technology (QUT), Australia. Congratulations Mohit!
Shuba presents a poster on her NFATc work in the EMBO lecture course on “Cancer systems biology: Promises of artificial intelligence“.
Atchuta’s paper on toggle triad is published in Journal of the Royal Society Interface. Congratulations Atchuta!
Kishore passes his qualifying exam. Congratulations Kishore!
Shuba’s paper on the role of NFATc in stabilizing hybrid E/M phenotype is published in Frontiers in Oncology. Congratulations Shuba!
Mohit is appointed as co-chair of Mathematical Oncology subgroup at the Society of Mathematical Biology. Congratulations Mohit!
Lab participates in the Annual Meeting of Society of Mathematical Biology (SMB) held virtually. Kishore, Shuba, Atchuta, Divyoj, Sarthak present posters.
Kishore’s paper on identifying strategies to inhibit cellular plasticity via network topology approach is published in NPJ Systems Biology and Applications. Congratulations Kishore!
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