I am a C. V. Raman Postdoctoral Fellow at the Centre for BioSystems Science and Engineering (BSSE) at IISc Bangalore.
The interdisciplinary field of biological physics — analytical and computational techniques of physics being applied to model different biological systems/processes to unravel its underlying mechanisms — has fascinated me for long.
During my PhD days in the department of Physics at IIT Madras, with Prof. Manoj Gopalakrishnan as my supervisor, I studied biophysical problems related to signal transduction and its relation to motility characteristics of E. coli. Thereafter, I joined as a Postdoctoral Research Associate in the department of Physics and Astronomy at Purdue University. With Dr. Andrew Mugler, I explored a generic model on the migratory behavior of a collection of cells, specifically, studied the effects of intercellular adhesion in migration of multicellular clusters.
And at BSSE, my overarching aim is to develop a model that integrates the essential biophysical features of heterogeneous cell migration, makes predictions for experimental data on epithelial mesenchymal transitions during cancer metastasis, and has the potential to reveal design principles for more effective therapeutic strategies which can prevent disease propagation.
My Recent Publications:
- Effects of cell-cell adhesion on collective migration of multicellular clusters. Ushasi Roy and Andrew Mugler. arXiv:2007.04550 (2020). DOI
- Statistics of correlated percolation in a bacterial community. Xiaoling Zhai, Joseph W. Larkin, Kaito Kikuchi, Samuel E. Redford, Ushasi Roy, Gürol M. Süel, Andrew Mugler. PLoS Comput. Biol. 15(12): e1007508 (2019) 1-19. DOI
- A path-integral formalism of the run and tumble motion and chemotaxis in Escherichia coli. C.S. Renadheer, Ushasi Roy, Manoj Gopalakrishnan. J. Phys. A : Math. Theor. 52, 505601 (2019). DOI
- Ultrasensitivity and fluctuations in the Barkai-Leibler model of chemotaxis receptors in Escherichia coli. Ushasi Roy and Manoj Gopalakrishnan. PLoS ONE 12(4): e0175309 (2017) 1-29. DOI
- Zero-order ultrasensitivity : A study of criticality and fluctuations under the total quasi-steady state approximation in the linear noise regime. P.K. Jithinraj, Ushasi Roy, Manoj Gopalakrishnan. J. Theor. Biol. 344 (2014) 1-11. DOI