BE Seminar: From design to healing: Engineering stimuli-responsive function biomaterials for advanced therapeutics

Speaker: Dr. Sayan Deb Dutta
Senior postdoctoral research fellow
Biorobotics Research Group, Kangwon National University, South Korea.

Date: 7th October 2025
Time: 10.00 AM
Venue: GF – 22, TCS Smart X Hub (TSH) Building

Title: From design to healing: Engineering stimuli-responsive function biomaterials for advanced therapeutics

Abstract: Stimuli-responsive smart biomaterials are revolutionizing advanced therapeutics by actively sensing and responding to physiological or external cues, such as pH, temperature, enzymes, light, or magnetic fields. Unlike traditional scaffolds, these systems provide precise control over drug release, immune regulation, and tissue repair, making them highly promising for chronic wound healing and regeneration. Advances in 3D printing/ bioprinting enable the fabrication of patient-specific, hierarchical constructs with spatially organized therapeutic components. The integration of functional nanomaterials—including 1D materials, 2D nanosheets (e.g., graphene, gC3N4, MXenes), and hybrid architectures—enhances responsiveness, mechanical robustness, and therapeutic delivery. Embedding flexible bioelectronics, such as photonic nanocrystals and conductive nanofillers, further enables real-time health sensing and feedback-controlled therapy, merging regenerative medicine with digital health technologies. In parallel, the incorporation of therapeutic molecules, such as exosomes and small peptides, promotes angiogenesis, reduces oxidative stress, and modulates the immune response, thereby accelerating the healing process. Applications extend beyond medicine to cellular agriculture, where bioprinted adaptive scaffolds support cultured tissues and sustainable protein production, leading to eco-friendly meat cultivation. Moreover, advanced bioimaging probes (e.g., carbon dots) enable non-invasive, high-resolution monitoring of biomaterial–cell interactions, tumor imaging, and in situ tissue remodeling. Together, these innovations establish next-generation stimuli-responsive multifunctional platforms, paving the way for personalized, durable, and adaptive healthcare solutions.

About the Speaker: Dr. Sayan Deb Dutta holds a Ph.D. degree in biosystems engineering with a major in biomaterials science and engineering. Currently, he serves as a senior postdoctoral research fellow at the Biorobotics Research group, Kangwon National University, South Korea. He joined as a visiting research fellow at the School of Medicine, University of California, Davis. He completed his master’s degree at the University of Kalyani, West Bengal, India. Over the past six years, he has been involved in the biomedical engineering field, where he has developed multi-material bioinks, primarily based on natural biopolymers, proteins, and carbohydrates, for 3D printing/bioprinting, immunomodulation, and tissue engineering applications. His current research focuses on the development of naturally inspired flexible bioelectronics, stimuli-responsive 3D scaffolds, and the fabrication of bioactive nanomaterials (e.g., homogeneous and heterogeneous nanoparticles, nano/bioglass, and nanocrystals) with tunable physicochemical properties for elucidating the mechanisms of different cellular communications, human healthcare sensing, tissue healing, and regeneration towards advanced therapeutics.