Speaker Name and Affiliation: Dr. Vinaya Simha, Mayo Clinic (currently Satish Dhawan visiting professor at IISc)

Seminar Title: Lipodystrophy and Insulin Resistance: Lessons learned and to be learned

Abstract: Lipodystrophy syndromes are a diverse group of congenital and acquired disorders characterized by selective fat loss and features of marked insulin resistance including early-onset diabetes, hyperlipidemia and hepatic steatosis. Much progress has been made recently in understanding the molecular basis of fat loss and metabolic complications. It has also thrown light on the pathogenesis of insulin resistance in obesity and metabolic syndrome and the importance of adipocyte endocrine function. Recent studies focusing on muscle mitochondrial dysfunction in lipodystrophy may help to further elucidate mechanisms of insulin resistance contributing to diabetes and dyslipidemia.

Brief Bio of Speaker: Prof. Simha is an Associate Professor of Medicine at the Mayo Clinic College of Medicine and Science and a Consultant in Endocrinology in the Department of Internal Medicine at Mayo Clinic, Rochester, Minnesota. He has won numerous awards, the latest of which is the 2018 Laureate Award from the Mayo Clinic. He has been an active clinical practitioner and researcher, specializing in diabetes and other endocrine disorders and their complications. He has been and is currently an investigator on several NIH grants and the lead investigator/director on clinical trials supported by the pharmaceutical industry.